SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		4 / 6 PRO A 213
GLN A 212
LYS A 207
VAL A 205
 None
 1.22A 1l2iB-2hfsA:
undetectable		 1l2iB-2hfsA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		3 / 3 ALA A  78
HIS A  79
VAL A  82
 None
 0.19A 1lqtB-2hfsA:
undetectable		 1lqtB-2hfsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		3 / 3 ALA A  78
HIS A  79
VAL A  82
 None
 0.20A 1lquB-2hfsA:
undetectable		 1lquB-2hfsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		4 / 4 LEU A 263
VAL A 267
CYH A 270
ALA A 275
 None
 1.10A 1mz9E-2hfsA:
undetectable		 1mz9E-2hfsA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 GLU A 144
ASN A 156
ILE A  20
GLY A 110
SER A 112
 None
 1.36A 1q8jA-2hfsA:
undetectable		 1q8jA-2hfsA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 8 ILE A 165
GLY A 163
GLY A  37
ILE A  38
ALA A 113
 None
 1.30A 1sguA-2hfsA:
undetectable		 1sguA-2hfsA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		4 / 8 SER A 152
ARG A 169
PHE A 176
ASP A 155
 None
 1.31A 1zzqB-2hfsA:
1.0		 1zzqB-2hfsA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 0.98A 3ln1A-2hfsA:
undetectable		 3ln1A-2hfsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 0.99A 3ln1B-2hfsA:
undetectable		 3ln1B-2hfsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 0.99A 3ln1C-2hfsA:
undetectable		 3ln1C-2hfsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 0.98A 3ln1D-2hfsA:
undetectable		 3ln1D-2hfsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		4 / 5 GLY A 145
GLU A 144
GLY A 146
PRO A 151
 None
 1.08A 3onnA-2hfsA:
undetectable		 3onnA-2hfsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 11 VAL A  19
ALA A  36
GLY A  37
TYR A  16
TYR A 186
 None
 1.29A 3qxyB-2hfsA:
0.0
3qxyQ-2hfsA:
undetectable		 3qxyB-2hfsA:
23.89
3qxyQ-2hfsA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 10 ILE A 109
VAL A 104
THR A 192
ILE A 266
ILE A 288
 None
 1.26A 3um5B-2hfsA:
undetectable		 3um5B-2hfsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		3 / 3 GLU A 264
ARG A 254
HIS A 250
 None
 0.77A 4kf9A-2hfsA:
undetectable		 4kf9A-2hfsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		4 / 8 LEU A 164
SER A 281
GLY A 243
MET A 246
 None
 0.87A 4klrB-2hfsA:
2.2		 4klrB-2hfsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 ASN A 156
VAL A 142
GLY A 143
SER A 139
LEU A 138
 None
 1.41A 4ot2A-2hfsA:
2.2		 4ot2A-2hfsA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 10 GLY A  54
GLY A  94
LEU A  55
LEU A 123
TYR A 127
 None
 1.30A 5hwkA-2hfsA:
undetectable		 5hwkA-2hfsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 10 GLY A  54
GLY A  94
LEU A  55
LEU A 123
TYR A 127
 None
 1.30A 5hwkB-2hfsA:
undetectable		 5hwkB-2hfsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 1.06A 5jw1A-2hfsA:
undetectable		 5jw1A-2hfsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 LEU A 242
ALA A 289
VAL A  19
ALA A  36
LEU A 164
 None
 1.03A 5jw1B-2hfsA:
undetectable		 5jw1B-2hfsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 9 LEU A  21
GLY A  37
ALA A 158
GLY A 110
ILE A 109
 None
 1.01A 5kr0B-2hfsA:
undetectable		 5kr0B-2hfsA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 ILE A 179
THR A 157
LEU A 185
LEU A 187
LEU A  21
 None
 0.87A 5nfjA-2hfsA:
undetectable		 5nfjA-2hfsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 VAL A 267
LEU A 187
GLY A 277
GLY A 282
ILE A 109
 None
 1.29A 5tuiB-2hfsA:
undetectable		 5tuiB-2hfsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		4 / 8 ARG A 121
ALA A 159
SER A  39
GLY A 162
 None
 1.01A 5v0vA-2hfsA:
2.6		 5v0vA-2hfsA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 9 TYR A 147
GLY A 145
GLY A 143
ALA A 140
VAL A 116
 None
 1.45A 5v3cA-2hfsA:
0.0		 5v3cA-2hfsA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		6 / 12 GLY A 287
GLU A  24
GLY A 284
ILE A 316
VAL A 290
GLY A 191
 None
 1.38A 5zhmB-2hfsA:
undetectable		 5zhmB-2hfsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 2hfs MEVALONATE KINASE,
PUTATIVE
(Leishmania
major) 		5 / 12 ASN A 156
VAL A 142
GLY A 143
SER A 139
LEU A 138
 None
 1.44A 6ci6A-2hfsA:
0.0		 6ci6A-2hfsA:
12.65