SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 THR A  19
LEU A  23
VAL A  26
LEU A  30
 None
 0.79A 1fbmD-2hg4A:
undetectable		 1fbmD-2hg4A:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.24A 1grmA-2hg4A:
undetectable		 1grmA-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.24A 1grmB-2hg4A:
undetectable		 1grmB-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 7 VAL A 226
VAL A 145
ARG A 118
LEU A 188
 None
 0.97A 1iepB-2hg4A:
undetectable		 1iepB-2hg4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 VAL A 368
SER A 367
GLY A 373
GLY A 243
THR A 336
 None
 1.08A 1jg4A-2hg4A:
undetectable		 1jg4A-2hg4A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.44A 1jnoA-2hg4A:
undetectable		 1jnoA-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.44A 1jnoB-2hg4A:
undetectable		 1jnoB-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA8_0
(GRAMICIDIN B)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.37A 1jo3A-2hg4A:
undetectable		 1jo3A-2hg4A:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB8_0
(GRAMICIDIN B)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.37A 1jo3B-2hg4A:
undetectable		 1jo3B-2hg4A:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA8_0
(GRAMICIDIN C)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.35A 1jo4A-2hg4A:
undetectable		 1jo4A-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB8_0
(GRAMICIDIN C)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.35A 1jo4B-2hg4A:
undetectable		 1jo4B-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A  19
LEU A  23
VAL A  26
 None
 0.56A 1mz9E-2hg4A:
undetectable		 1mz9E-2hg4A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.36A 1nrmA-2hg4A:
undetectable		 1nrmA-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.36A 1nrmB-2hg4A:
undetectable		 1nrmB-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.43A 1nruA-2hg4A:
undetectable		 1nruA-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB8_0
(GRAMICIDIN A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 4 GLY A 366
VAL A 331
TRP A 364
TRP A 425
 None
 1.43A 1nruB-2hg4A:
undetectable		 1nruB-2hg4A:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 10 GLY A 150
VAL A 149
GLY A 148
VAL A 152
HIS A 374
 None
 1.25A 1v3qE-2hg4A:
undetectable		 1v3qE-2hg4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A  41
ALA A  42
ALA A 277
HIS A 207
LEU A 206
 None
 0.99A 1xiuB-2hg4A:
undetectable		 1xiuB-2hg4A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 ASP A 114
VAL A 169
PRO A 162
 None
 0.69A 2avvA-2hg4A:
undetectable		 2avvA-2hg4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 ARG A 215
VAL A 293
GLY A 202
 None
 0.50A 2avvE-2hg4A:
undetectable		 2avvE-2hg4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 VAL A 845
VAL A 827
ASP A 803
 None
 0.78A 2fumD-2hg4A:
undetectable		 2fumD-2hg4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 5 LEU A 571
ALA A 579
ILE A 582
SER A 623
 None
 1.10A 2othA-2hg4A:
2.4		 2othA-2hg4A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 743
GLY A 678
GLY A 679
ALA A 681
GLY A 719
 None
 0.89A 2pkmA-2hg4A:
undetectable		 2pkmA-2hg4A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 382
GLY A 335
GLY A 373
ALA A 333
LEU A 349
 None
 0.98A 2plwA-2hg4A:
undetectable		 2plwA-2hg4A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		6 / 12 LEU A 262
GLY A 259
ALA A 245
ASP A 247
ILE A  71
ALA A 263
 None
 1.35A 2rkfB-2hg4A:
undetectable		 2rkfB-2hg4A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 SER A 212
ALA A 192
PRO A 191
LEU A 269
VAL A 268
 None
 1.18A 2zifB-2hg4A:
undetectable		 2zifB-2hg4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 7 VAL A 713
SER A 705
HIS A 641
LEU A 825
 None
 1.10A 3arrA-2hg4A:
undetectable		 3arrA-2hg4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 724
MET A 680
ALA A 681
VAL A 713
LEU A 795
 None
ACT  A 950 ( 4.5A)
None
None
None
 1.26A 3b0wA-2hg4A:
undetectable		 3b0wA-2hg4A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 SER A 175
GLY A 150
GLY A 148
 None
 0.57A 3bogA-2hg4A:
undetectable
3bogC-2hg4A:
undetectable		 3bogA-2hg4A:
undetectable
3bogC-2hg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 378
VAL A 448
GLU A 332
VAL A  54
ILE A 372
 None
 1.20A 3dl9A-2hg4A:
undetectable		 3dl9A-2hg4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A 638
PHE A 557
HIS A 641
VAL A 799
 None
 1.05A 3fhxB-2hg4A:
undetectable		 3fhxB-2hg4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 ASP A 722
LEU A 721
GLN A 748
 None
 0.77A 3g4lA-2hg4A:
undetectable		 3g4lA-2hg4A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 10 THR A 194
SER A 179
VAL A 268
GLY A 148
GLY A 225
 None
 1.31A 3ixlA-2hg4A:
2.6		 3ixlA-2hg4A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A 870
GLY A 552
ALA A 815
PHE A 816
ALA A 843
 None
 1.11A 3sudB-2hg4A:
undetectable		 3sudB-2hg4A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A 267
ALA A 382
ARG A 130
ILE A 123
GLU A 126
 None
 1.03A 4azsA-2hg4A:
undetectable		 4azsA-2hg4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A 267
ALA A 382
ARG A 130
ILE A 123
GLU A 126
 None
 1.04A 4azwA-2hg4A:
undetectable		 4azwA-2hg4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A 148
ALA A 266
ALA A 178
ASP A 196
VAL A 149
 None
 1.36A 4df3A-2hg4A:
undetectable		 4df3A-2hg4A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 9 GLU A 525
GLY A 521
VAL A 519
PRO A 469
GLY A 503
 None
 1.25A 4fimA-2hg4A:
2.2		 4fimA-2hg4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 6 THR A 775
VAL A 827
SER A 705
ASP A 834
 None
 1.16A 4iaqA-2hg4A:
undetectable		 4iaqA-2hg4A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 11 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.09A 4j6cA-2hg4A:
undetectable		 4j6cA-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 10 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.09A 4j6cB-2hg4A:
undetectable		 4j6cB-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.02A 4j6dA-2hg4A:
undetectable		 4j6dA-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.02A 4j6dB-2hg4A:
undetectable		 4j6dB-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.04A 4jbtA-2hg4A:
undetectable		 4jbtA-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 11 ALA A 382
ALA A 379
ALA A 378
VAL A 228
LEU A  92
 None
 1.03A 4jbtB-2hg4A:
undetectable		 4jbtB-2hg4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A 337
GLY A 335
SER A 370
ASP A 247
ALA A 245
 None
 0.90A 4krhA-2hg4A:
undetectable		 4krhA-2hg4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		7 / 12 ALA A 198
CYH A 199
PHE A 238
HIS A 334
THR A 336
HIS A 374
GLY A 440
 None
 0.87A 4ls7A-2hg4A:
49.9		 4ls7A-2hg4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		7 / 12 GLY A 150
ALA A 198
CYH A 199
HIS A 334
THR A 336
HIS A 374
GLY A 440
 None
 0.66A 4ls7A-2hg4A:
49.9		 4ls7A-2hg4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		7 / 12 ALA A 198
CYH A 199
PHE A 238
HIS A 334
THR A 336
HIS A 374
GLY A 440
 None
 0.87A 4ls7A-2hg4A:
49.9
4ls7B-2hg4A:
49.7		 4ls7A-2hg4A:
19.04
4ls7B-2hg4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 7 ARG A 486
VAL A 889
GLU A 126
ARG A 130
 None
 0.97A 4mv7A-2hg4A:
4.3		 4mv7A-2hg4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A 288
GLU A 211
VAL A 293
ALA A 446
 None
 0.78A 4nkxA-2hg4A:
undetectable		 4nkxA-2hg4A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 5 ILE A  41
LEU A 288
GLU A 211
VAL A 293
 None
 0.83A 4nkxB-2hg4A:
undetectable		 4nkxB-2hg4A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 ALA A 198
GLN A 310
GLY A 307
 None
 0.54A 4odoC-2hg4A:
0.3		 4odoC-2hg4A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 LEU A 772
ASP A 782
ILE A 646
 None
 0.70A 4xi3D-2hg4A:
undetectable		 4xi3D-2hg4A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 MET A 120
ILE A 123
VAL A 145
GLY A  45
THR A 147
 None
 1.18A 5byjA-2hg4A:
undetectable		 5byjA-2hg4A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 5 ALA A 743
TYR A 742
GLY A 847
LEU A 617
 None
 0.74A 5eslA-2hg4A:
0.4		 5eslA-2hg4A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A 738
ALA A 681
GLY A 679
LEU A 721
GLY A 559
 None
 1.17A 5i71A-2hg4A:
undetectable		 5i71A-2hg4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A 738
ALA A 681
GLY A 679
LEU A 721
GLY A 559
 None
 1.19A 5i75A-2hg4A:
undetectable		 5i75A-2hg4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 THR A 444
ALA A 205
ALA A 223
LEU A 269
GLY A 202
 None
 1.35A 5jglA-2hg4A:
undetectable		 5jglA-2hg4A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 TRP A  80
GLY A 233
PRO A 232
ASP A 153
 None
 1.07A 5kf8A-2hg4A:
undetectable		 5kf8A-2hg4A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 TRP A  80
GLY A 233
PRO A 232
ASP A 153
 None
 1.09A 5kgpA-2hg4A:
undetectable		 5kgpA-2hg4A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 TRP A  80
GLY A 233
PRO A 232
ASP A 153
 None
 1.10A 5kgpB-2hg4A:
undetectable		 5kgpB-2hg4A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 5 GLU A 574
GLY A 854
ARG A 569
GLY A 566
 None
 1.07A 5kprA-2hg4A:
undetectable		 5kprA-2hg4A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 8 VAL A 714
ILE A 694
ALA A 691
THR A 687
VAL A 712
 None
 1.48A 5l94A-2hg4A:
undetectable		 5l94A-2hg4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ASP A  83
ALA A  74
THR A 227
ARG A 239
LEU A 262
 None
 1.40A 5m54B-2hg4A:
2.1		 5m54B-2hg4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 808
ALA A 809
GLU A 818
ALA A 866
ALA A 815
 None
 1.10A 5n5dB-2hg4A:
undetectable		 5n5dB-2hg4A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.99A 5sxqA-2hg4A:
undetectable		 5sxqA-2hg4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.99A 5sxqB-2hg4A:
undetectable		 5sxqB-2hg4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.95A 5sxtA-2hg4A:
undetectable		 5sxtA-2hg4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.96A 5sxtB-2hg4A:
undetectable		 5sxtB-2hg4A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.97A 5syjA-2hg4A:
undetectable		 5syjA-2hg4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A 889
GLY A 485
GLN A 483
LEU A 487
 None
 0.98A 5syjB-2hg4A:
undetectable		 5syjB-2hg4A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A  92
GLY A 383
ILE A 119
THR A 147
GLY A 380
 None
 1.07A 5veuH-2hg4A:
undetectable		 5veuH-2hg4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 6 ALA A 484
GLN A 483
GLN A 893
ASP A 476
 None
 1.22A 5y9aA-2hg4A:
2.6		 5y9aA-2hg4A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 10 SER A 141
GLY A 140
ALA A 183
LEU A 186
PHE A  50
 None
 1.00A 5zjiA-2hg4A:
undetectable
5zjiJ-2hg4A:
undetectable		 5zjiA-2hg4A:
6.44
5zjiJ-2hg4A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A  41
ALA A  42
ALA A 277
HIS A 207
LEU A 206
 None
 0.96A 6a5zL-2hg4A:
undetectable		 6a5zL-2hg4A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A  41
ALA A  42
ALA A 277
HIS A 207
LEU A 206
 None
 1.02A 6a60D-2hg4A:
undetectable		 6a60D-2hg4A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		4 / 7 GLY A 224
SER A 201
GLY A 202
VAL A 381
 None
 0.88A 6ekzA-2hg4A:
undetectable		 6ekzA-2hg4A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		3 / 3 VAL A  44
ALA A 131
GLN A 272
 None
 0.68A 6gb9A-2hg4A:
3.9		 6gb9A-2hg4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A 617
THR A 826
ALA A 568
ARG A 853
LEU A 624
 None
 1.14A 6ie8A-2hg4A:
undetectable		 6ie8A-2hg4A:
11.32