SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 5 PHE A 239
TYR A 275
LEU A 103
ASP A 268
 None
 1.24A 1dz6A-2hgsA:
undetectable		 1dz6A-2hgsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 12 GLY A 446
LEU A 180
PRO A 471
LEU A 426
ALA A  65
 None
 0.95A 1gseB-2hgsA:
undetectable		 1gseB-2hgsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		3 / 3 ARG A 230
VAL A 206
TRP A 196
 None
 1.26A 1qwcA-2hgsA:
undetectable		 1qwcA-2hgsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 7 ASP A 219
PHE A 429
SER A 157
ARG A 158
 None
 1.02A 1rqpB-2hgsA:
undetectable		 1rqpB-2hgsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 ASP A 219
PHE A 429
SER A 157
ARG A 158
 None
 1.01A 1rqpC-2hgsA:
undetectable		 1rqpC-2hgsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 ASP A 219
PHE A 429
SER A 157
ARG A 158
 None
 1.03A 1rqpA-2hgsA:
undetectable		 1rqpA-2hgsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 5 ALA A 150
ASN A 146
ILE A 145
ASP A 127
 GSH  A 503 (-4.8A)
MG  A 501 ( 2.7A)
None
SO4  A 505 ( 4.8A)
 1.18A 1yc2D-2hgsA:
undetectable		 1yc2D-2hgsA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 TYR A 265
LEU A 208
GLU A 214
ALA A 210
 None
None
GSH  A 503 (-2.4A)
None
 1.02A 2bnnA-2hgsA:
undetectable
2bnnB-2hgsA:
undetectable		 2bnnA-2hgsA:
18.39
2bnnB-2hgsA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 8 ARG A 267
GLY A 369
GLY A 460
ALA A 462
ALA A 463
 GSH  A 503 (-3.7A)
SO4  A 505 ( 3.3A)
GSH  A 503 (-3.6A)
GSH  A 503 (-3.5A)
None
 1.47A 2ej3C-2hgsA:
undetectable		 2ej3C-2hgsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		3 / 3 ARG A 412
THR A 451
VAL A 467
 SO4  A 504 (-3.6A)
None
None
 0.99A 2qakA-2hgsA:
undetectable		 2qakA-2hgsA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 6 LEU A 426
LEU A 449
ILE A 428
ARG A 125
 None
None
None
SO4  A 505 ( 3.0A)
 1.07A 2rlfA-2hgsA:
undetectable
2rlfB-2hgsA:
undetectable		 2rlfA-2hgsA:
8.41
2rlfB-2hgsA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 6 LEU A 207
LEU A 205
ILE A 242
ARG A 237
 None
 1.14A 2rlfB-2hgsA:
undetectable
2rlfC-2hgsA:
undetectable		 2rlfB-2hgsA:
8.41
2rlfC-2hgsA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 6 LEU A 426
LEU A 449
ILE A 428
ARG A 125
 None
None
None
SO4  A 505 ( 3.0A)
 0.98A 2rlfC-2hgsA:
undetectable
2rlfD-2hgsA:
undetectable		 2rlfC-2hgsA:
8.41
2rlfD-2hgsA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 ASP A 219
PHE A 429
SER A 157
ARG A 158
 None
 1.00A 2v7uA-2hgsA:
undetectable		 2v7uA-2hgsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 7 ASP A 219
PHE A 429
SER A 157
ARG A 158
 None
 1.02A 2v7uB-2hgsA:
undetectable		 2v7uB-2hgsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 SER A 126
VAL A  76
TYR A 128
ASN A 442
 None
 1.27A 2wekA-2hgsA:
undetectable		 2wekA-2hgsA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 SER A 126
VAL A  76
TYR A 128
ASN A 442
 None
 1.24A 2wekB-2hgsA:
undetectable		 2wekB-2hgsA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 11 GLU A 144
GLY A 427
ILE A 428
PHE A  72
ALA A  65
 MG  A 501 ( 1.9A)
None
None
None
None
 1.17A 3nmuB-2hgsA:
undetectable
3nmuJ-2hgsA:
undetectable		 3nmuB-2hgsA:
22.65
3nmuJ-2hgsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 4 LEU A 448
GLY A 427
LEU A 426
GLU A 425
 None
None
None
ADP  A 500 (-2.6A)
 0.88A 3tgvB-2hgsA:
undetectable		 3tgvB-2hgsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 12 LEU A 121
LEU A 188
GLY A 187
ILE A 223
ALA A 222
 None
 1.07A 3uwlD-2hgsA:
undetectable		 3uwlD-2hgsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 ARG A  25
HIS A 165
VAL A 169
GLN A  21
 None
 1.12A 3uy4A-2hgsA:
undetectable		 3uy4A-2hgsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 12 GLY A 191
GLY A 187
LEU A 227
TYR A 265
VAL A 263
 None
 0.98A 4f84A-2hgsA:
undetectable		 4f84A-2hgsA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 11 GLN A 117
ALA A 292
ALA A 291
ALA A 262
VAL A 234
 None
 1.14A 4jbtB-2hgsA:
undetectable		 4jbtB-2hgsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 5 LEU A 338
GLY A 337
ILE A 143
GLN A 142
 None
None
ADP  A 500 (-4.5A)
None
 1.16A 4ma8C-2hgsA:
undetectable		 4ma8C-2hgsA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		3 / 3 GLU A 425
ARG A 450
GLN A 308
 ADP  A 500 (-2.6A)
SO4  A 505 ( 3.1A)
None
 0.90A 4rtbA-2hgsA:
undetectable		 4rtbA-2hgsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		3 / 3 LEU A  32
VAL A  23
ASP A  24
 None
 0.54A 4y8wC-2hgsA:
undetectable		 4y8wC-2hgsA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 6 ASP A  71
THR A 147
THR A 299
VAL A  76
 None
 1.15A 4yoaA-2hgsA:
undetectable		 4yoaA-2hgsA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		3 / 3 ARG A 230
VAL A 206
TRP A 196
 None
 1.22A 5fvoA-2hgsA:
undetectable		 5fvoA-2hgsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 5 PHE A 239
LEU A 103
ASP A 268
ILE A 209
 None
 0.86A 5ik1A-2hgsA:
undetectable		 5ik1A-2hgsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 6 HIS A 163
VAL A 162
LEU A 411
THR A  51
 None
 1.25A 5ogjA-2hgsA:
undetectable		 5ogjA-2hgsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 6 HIS A 163
VAL A 162
LEU A 411
THR A  51
 None
 1.23A 5ogjB-2hgsA:
undetectable		 5ogjB-2hgsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 5 HIS A 163
VAL A 162
LEU A 411
THR A  51
 None
 1.23A 5ohhA-2hgsA:
undetectable		 5ohhA-2hgsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 5 VAL A 307
THR A 304
LEU A 320
LEU A 331
 None
 0.86A 6bqgA-2hgsA:
undetectable		 6bqgA-2hgsA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 ILE A 396
GLN A 366
THR A 100
SER A  91
 None
 0.96A 6c06C-2hgsA:
undetectable		 6c06C-2hgsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 7 ILE A 454
GLN A 421
VAL A 420
THR A  51
 None
 0.95A 6cduC-2hgsA:
undetectable
6cduD-2hgsA:
undetectable		 6cduC-2hgsA:
20.84
6cduD-2hgsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 7 ILE A 454
GLN A 421
VAL A 420
THR A  51
 None
 0.95A 6cduF-2hgsA:
undetectable
6cduG-2hgsA:
undetectable		 6cduF-2hgsA:
20.84
6cduG-2hgsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		4 / 8 ILE A 454
GLN A 421
VAL A 420
THR A  51
 None
 0.93A 6cduG-2hgsA:
undetectable
6cduH-2hgsA:
undetectable		 6cduG-2hgsA:
20.84
6cduH-2hgsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 12 ILE A 235
ASP A 257
GLY A 258
ILE A 242
LEU A 254
 None
 1.05A 6dwnC-2hgsA:
undetectable		 6dwnC-2hgsA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens) 		5 / 12 ILE A 235
ASP A 257
GLY A 258
ILE A 242
LEU A 254
 None
 1.06A 6dwnD-2hgsA:
undetectable		 6dwnD-2hgsA:
10.59