SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hh9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 12 ASP A 233
THR A 207
SER A 210
ILE A 211
LEU A 270
 None
 1.04A 1ddrA-2hh9A:
undetectable		 1ddrA-2hh9A:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IG0_A_VIBA702_1
(THIAMIN
PYROPHOSPHOKINASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 10 VAL A  11
TRP A 290
SER A 299
SER A 301
ASN A 302
 None
 1.45A 1ig0A-2hh9A:
34.0
1ig0B-2hh9A:
34.2		 1ig0A-2hh9A:
35.77
1ig0B-2hh9A:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IG0_B_VIBB701_1
(THIAMIN
PYROPHOSPHOKINASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 9 VAL A  11
TRP A 290
SER A 299
SER A 301
ASN A 302
 None
 1.44A 1ig0A-2hh9A:
34.0
1ig0B-2hh9A:
34.2		 1ig0A-2hh9A:
35.77
1ig0B-2hh9A:
35.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 12 ASP A 233
THR A 207
SER A 210
ILE A 211
LEU A 270
 None
 0.99A 1rg7A-2hh9A:
undetectable		 1rg7A-2hh9A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 10 SER A 130
ILE A  74
LEU A  84
ASN A  82
ILE A 117
 None
 1.22A 2nnhB-2hh9A:
undetectable		 2nnhB-2hh9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		3 / 3 GLY A 112
ASP A 142
SER A 146
 MG  A 804 ( 4.9A)
MG  A 802 ( 2.4A)
None
 0.68A 2qhfA-2hh9A:
undetectable		 2qhfA-2hh9A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 10 GLY A 306
GLY A 309
THR A 308
TYR A 247
ILE A  19
 None
 1.26A 3fw1A-2hh9A:
undetectable		 3fw1A-2hh9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 5 LEU A  54
ALA A 199
PHE A 228
ASN A 141
 None
 1.27A 3uq6A-2hh9A:
undetectable		 3uq6A-2hh9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 4 LEU A  54
ALA A 199
PHE A 228
ASN A 141
 None
 1.28A 3vaqA-2hh9A:
3.1		 3vaqA-2hh9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 4 LEU A  54
ALA A 199
PHE A 228
ASN A 141
 None
 1.29A 3vasA-2hh9A:
undetectable		 3vasA-2hh9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 5 VAL A 319
LEU A 268
LEU A 270
ILE A 200
 None
 0.91A 4a9jB-2hh9A:
undetectable		 4a9jB-2hh9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 5 VAL A 319
LEU A 268
LEU A 270
ILE A 200
 None
 0.88A 4a9jC-2hh9A:
undetectable		 4a9jC-2hh9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 12 ILE A 304
PHE A  37
TYR A  39
LEU A 197
LEU A  67
 None
 1.06A 4j03A-2hh9A:
3.1		 4j03A-2hh9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 11 TYR A 247
GLN A  14
SER A 305
LEU A  18
ILE A  20
 None
 1.48A 4k37A-2hh9A:
undetectable		 4k37A-2hh9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 11 TYR A 247
GLN A  14
SER A 305
LEU A  18
ILE A  20
 None
 1.48A 4k37B-2hh9A:
1.8		 4k37B-2hh9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 8 LEU A 173
LEU A 176
LEU A 180
ILE A 133
 None
 0.80A 4klaA-2hh9A:
undetectable		 4klaA-2hh9A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 8 VAL A 319
LEU A 268
LEU A 270
ILE A 200
 None
 0.85A 4lzrA-2hh9A:
undetectable		 4lzrA-2hh9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 4 ILE A  34
ASN A 243
ILE A 318
VAL A 319
 None
 1.26A 4uy87-2hh9A:
undetectable		 4uy87-2hh9A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 11 ILE A 133
LEU A  54
ASP A  78
GLY A 112
ALA A  81
 None
None
MG  A 802 (-3.3A)
MG  A 804 ( 4.9A)
None
 1.29A 5fctA-2hh9A:
undetectable		 5fctA-2hh9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		5 / 8 VAL A 312
ILE A  34
LEU A 238
ILE A 322
SER A 305
 None
 1.38A 5numA-2hh9A:
undetectable		 5numA-2hh9A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2hh9 THIAMIN
PYROPHOSPHOKINASE
(Candida
albicans) 		4 / 6 PRO A 107
ILE A 132
GLY A 129
GLU A 126
 None
 0.83A 6gqiA-2hh9A:
undetectable		 6gqiA-2hh9A:
19.48