SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		5 / 8 GLY A 118
GLY A 119
GLY A 121
ALA A 122
ILE A  56
 None
 1.04A 1yajC-2hhgA:
undetectable		 1yajC-2hhgA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		5 / 9 GLY A  58
ILE A  41
ALA A  36
VAL A  39
PHE A  88
 None
 1.39A 2drdA-2hhgA:
undetectable		 2drdA-2hhgA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 127
ALA A 126
ASP A 125
GLY A 119
ILE A  56
 None
 0.78A 2fxeA-2hhgA:
undetectable		 2fxeA-2hhgA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		3 / 3 TYR A  91
GLY A  94
PHE A 120
 None
PO4  A4285 (-3.1A)
None
 0.62A 2m2pB-2hhgA:
undetectable		 2m2pB-2hhgA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		4 / 8 GLY A  95
ASN A  17
ALA A 122
GLU A 117
 PO4  A4285 (-4.0A)
None
None
None
 0.93A 2x0pA-2hhgA:
undetectable		 2x0pA-2hhgA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		5 / 9 ALA A  28
ASP A  27
GLY A 128
ILE A 130
ILE A 116
 None
 1.11A 3ekvB-2hhgA:
undetectable		 3ekvB-2hhgA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		6 / 11 GLY A 127
ALA A 126
ASP A 125
GLY A 119
ILE A  56
THR A  24
 None
 1.03A 3ufnA-2hhgA:
undetectable		 3ufnA-2hhgA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		5 / 8 VAL A  42
ALA A 114
VAL A  39
HIS A  32
VAL A  40
 None
 1.32A 5l94A-2hhgA:
undetectable		 5l94A-2hhgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 101
PHE A  90
GLN A  83
GLY A 109
LEU A 110
 None
 1.24A 5m54E-2hhgA:
undetectable		 5m54E-2hhgA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 2hhg HYPOTHETICAL PROTEIN
RPA3614
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 127
ALA A 126
ASP A 125
GLY A 119
ILE A  56
 None
 0.86A 6dj1A-2hhgA:
undetectable		 6dj1A-2hhgA:
20.44