SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C12_B_SPMB1433_1 (NITROALKANE OXIDASE)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	5 / 11	VAL A 90 ALA A 109 SER A 43 LEU A 44 ASP A 40	None	1.33A	2c12B-2hhiA: 0.0	2c12B-2hhiA: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C12_D_SPMD1434_1 (NITROALKANE OXIDASE)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	5 / 10	VAL A 90 ALA A 109 SER A 43 LEU A 44 ASP A 40	None	1.34A	2c12D-2hhiA: 0.0	2c12D-2hhiA: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C12_F_SPMF1433_1 (NITROALKANE OXIDASE)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	5 / 11	VAL A 90 ALA A 109 SER A 43 LEU A 44 ASP A 40	None	1.36A	2c12F-2hhiA: undetectable	2c12F-2hhiA: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VFT_A_SORA1419_0 (XYLITOL OXIDASE)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	5 / 12	HIS A 102 PRO A 103 THR A 105 GLU A 187 THR A 106	None	1.34A	2vftA-2hhiA: 0.0	2vftA-2hhiA: 18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RFM_A_CFFA330_1 (ADENOSINE RECEPTOR A2A)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	4 / 7	VAL A 170 PHE A 177 LEU A 205 ILE A 201	None	0.98A	3rfmA-2hhiA: undetectable	3rfmA-2hhiA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I1N_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	5 / 11	ILE A 176 ALA A 109 PHE A 178 LEU A 185 TYR A 78	None	1.38A	4i1nA-2hhiA: undetectable	4i1nA-2hhiA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FHZ_A_REAA602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	5 / 12	ILE A 201 GLY A 174 ARG A 198 THR A 171 PHE A 177	None	1.47A	5fhzA-2hhiA: undetectable	5fhzA-2hhiA: 15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G1P_A_ACTA403_0 (ADP-RIBOSYLHYDROLASE LIKE 2)	2hhi	IMMUNOGENIC PROTEIN MPT64 (Mycobacterium tuberculosis)	3 / 3	TYR A 6 ASP A 40 GLN A 41	None	0.90A	6g1pA-2hhiA: undetectable	6g1pA-2hhiA: 20.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2C12_B_SPMB1433_1","NITROALKANE OXIDASE","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",5,"VAL A  90;ALA A 109;SER A  43;LEU A  44;ASP A  40","None","1.33A","2c12B-2hhiA:0.0","2c12B-2hhiA:17.50"],["2C12_D_SPMD1434_1","NITROALKANE OXIDASE","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",5,"VAL A  90;ALA A 109;SER A  43;LEU A  44;ASP A  40","None","1.34A","2c12D-2hhiA:0.0","2c12D-2hhiA:17.50"],["2C12_F_SPMF1433_1","NITROALKANE OXIDASE","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",5,"VAL A  90;ALA A 109;SER A  43;LEU A  44;ASP A  40","None","1.36A","2c12F-2hhiA:undetectable","2c12F-2hhiA:17.50"],["2VFT_A_SORA1419_0","XYLITOL OXIDASE","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",5,"HIS A 102;PRO A 103;THR A 105;GLU A 187;THR A 106","None","1.34A","2vftA-2hhiA:0.0","2vftA-2hhiA:18.66"],["3RFM_A_CFFA330_1","ADENOSINE RECEPTOR A2A","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",4,"VAL A 170;PHE A 177;LEU A 205;ILE A 201","None","0.98A","3rfmA-2hhiA:undetectable","3rfmA-2hhiA:20.00"],["4I1N_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",5,"ILE A 176;ALA A 109;PHE A 178;LEU A 185;TYR A  78","None","1.38A","4i1nA-2hhiA:undetectable","4i1nA-2hhiA:18.75"],["5FHZ_A_REAA602_1","ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",5,"ILE A 201;GLY A 174;ARG A 198;THR A 171;PHE A 177","None","1.47A","5fhzA-2hhiA:undetectable","5fhzA-2hhiA:15.62"],["6G1P_A_ACTA403_0","ADP-RIBOSYLHYDROLASE LIKE 2","2hhi","IMMUNOGENIC PROTEIN MPT64","Mycobacterium tuberculosis",3,"TYR A   6;ASP A  40;GLN A  41","None","0.90A","6g1pA-2hhiA:undetectable","6g1pA-2hhiA:20.00"]]