SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 SER A 146
SER A 118
LEU A  88
ASP A  36
GLU A  37
 None
 1.31A 3aocC-2hhlA:
undetectable		 3aocC-2hhlA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens) 		6 / 12 ALA A 101
LEU A  88
LEU A  77
GLN A  78
LEU A 172
VAL A  40
 None
 1.47A 3ix9B-2hhlA:
undetectable		 3ix9B-2hhlA:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ASP A  36
PHE A  44
SER A  92
TYR A  96
 None
KEG  A 902 (-3.8A)
None
None
 0.81A 3pglA-2hhlA:
28.9		 3pglA-2hhlA:
75.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 7 ASP A  36
VAL A  56
ILE A  58
SER A  92
TYR A  96
 None
 0.59A 3pglA-2hhlA:
28.9		 3pglA-2hhlA:
75.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 2hhl CTD SMALL
PHOSPHATASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ASP A  25
GLU A  85
PRO A  19
VAL A  87
 None
 1.06A 4hvrA-2hhlA:
undetectable		 4hvrA-2hhlA:
24.04