SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hi0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 8 GLU A  88
ARG A  91
LEU A  59
GLU A  62
 None
 0.54A 1cmaA-2hi0A:
undetectable
1cmaB-2hi0A:
undetectable		 1cmaA-2hi0A:
17.11
1cmaB-2hi0A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 11 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  83
 None
 0.85A 1cmaA-2hi0A:
undetectable
1cmaB-2hi0A:
undetectable		 1cmaA-2hi0A:
17.11
1cmaB-2hi0A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 10 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  83
 None
 0.85A 1cmcA-2hi0A:
undetectable
1cmcB-2hi0A:
undetectable		 1cmcA-2hi0A:
17.11
1cmcB-2hi0A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 8 LEU A  59
PHE A  29
LEU A  93
ALA A  28
 None
 0.85A 1fiqC-2hi0A:
undetectable		 1fiqC-2hi0A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 7 PHE A  38
ALA A  58
LEU A  59
VAL A  92
 None
 0.94A 1hk2A-2hi0A:
undetectable		 1hk2A-2hi0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 12 ALA A  83
GLU A  88
ARG A  91
LEU A  59
GLU A  62
 None
 0.84A 1mj2A-2hi0A:
undetectable
1mj2B-2hi0A:
undetectable		 1mj2A-2hi0A:
17.98
1mj2B-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 9 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  63
 None
 0.83A 1mj2A-2hi0A:
undetectable		 1mj2A-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 9 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  63
 None
 0.84A 1mj2C-2hi0A:
undetectable		 1mj2C-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 12 ALA A  83
GLU A  88
ARG A  91
LEU A  59
GLU A  62
 None
 0.85A 1mj2C-2hi0A:
undetectable
1mj2D-2hi0A:
undetectable		 1mj2C-2hi0A:
17.98
1mj2D-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 11 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  63
 None
 0.86A 1mjlA-2hi0A:
undetectable
1mjlB-2hi0A:
undetectable		 1mjlA-2hi0A:
17.98
1mjlB-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 9 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  63
 None
 0.87A 1mjoA-2hi0A:
undetectable		 1mjoA-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 9 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  63
 None
 0.88A 1mjoB-2hi0A:
undetectable		 1mjoB-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 12 ALA A  83
GLU A  88
ARG A  91
LEU A  59
GLU A  62
 None
 0.91A 1mjoC-2hi0A:
undetectable
1mjoD-2hi0A:
undetectable		 1mjoC-2hi0A:
17.98
1mjoD-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 9 GLU A  88
ARG A  91
LEU A  59
GLU A  62
ALA A  63
 None
 0.87A 1mjoC-2hi0A:
undetectable		 1mjoC-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 12 ALA A  83
GLU A  88
LEU A  59
GLU A  62
ALA A  63
 None
 1.06A 1mjqC-2hi0A:
undetectable
1mjqD-2hi0A:
undetectable		 1mjqC-2hi0A:
17.98
1mjqD-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 12 ALA A  83
GLU A  88
LEU A  59
GLU A  62
ALA A  63
 None
 1.05A 1mjqI-2hi0A:
undetectable
1mjqJ-2hi0A:
undetectable		 1mjqI-2hi0A:
17.98
1mjqJ-2hi0A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 7 THR A 170
VAL A 174
SER A 171
ARG A 181
 None
ACT  A 243 (-4.7A)
None
None
 1.06A 2v2gA-2hi0A:
2.6
2v2gB-2hi0A:
2.5		 2v2gA-2hi0A:
20.97
2v2gB-2hi0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 7 THR A 170
VAL A 174
SER A 171
ARG A 181
 None
ACT  A 243 (-4.7A)
None
None
 1.07A 2v2gC-2hi0A:
2.6
2v2gD-2hi0A:
2.6		 2v2gC-2hi0A:
20.97
2v2gD-2hi0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 7 THR A 170
VAL A 174
SER A 171
ARG A 181
 None
ACT  A 243 (-4.7A)
None
None
 1.06A 2v41E-2hi0A:
2.5
2v41F-2hi0A:
2.2		 2v41E-2hi0A:
20.97
2v41F-2hi0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 7 THR A 170
VAL A 174
SER A 171
ARG A 181
 None
ACT  A 243 (-4.7A)
None
None
 1.08A 2v41E-2hi0A:
2.5
2v41F-2hi0A:
2.2		 2v41E-2hi0A:
20.97
2v41F-2hi0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 10 VAL A 185
ALA A 197
ILE A 194
ILE A 225
ILE A 205
 None
 1.17A 3clbD-2hi0A:
2.4		 3clbD-2hi0A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 8 PHE A  96
ALA A  24
THR A 108
LEU A 142
 None
 0.97A 3khmA-2hi0A:
undetectable		 3khmA-2hi0A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 5 ARG A  91
THR A  32
GLU A  62
GLU A  88
 None
 1.44A 3ny4A-2hi0A:
undetectable		 3ny4A-2hi0A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 11 ILE A  43
ASP A  11
PHE A  47
LEU A  25
THR A  17
 None
 1.25A 3qg2B-2hi0A:
3.7		 3qg2B-2hi0A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 8 ILE A 114
ILE A 187
PHE A   8
GLU A 234
 None
 0.80A 3ua5A-2hi0A:
undetectable		 3ua5A-2hi0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 8 LEU A  59
PHE A  29
LEU A  93
ALA A  28
 None
 0.92A 3uniB-2hi0A:
undetectable		 3uniB-2hi0A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 7 PRO A 165
ILE A 192
GLY A  74
VAL A  53
 None
None
EDO  A 247 (-3.4A)
EDO  A 247 ( 4.7A)
 0.92A 4a3uB-2hi0A:
undetectable		 4a3uB-2hi0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		3 / 3 ASP A  11
ARG A  57
THR A  17
 None
 0.84A 4i13A-2hi0A:
undetectable		 4i13A-2hi0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 4 ILE A  43
ASP A  11
ARG A  57
THR A  17
 None
 1.10A 4nx6A-2hi0A:
3.0		 4nx6A-2hi0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		4 / 4 ILE A  43
ASP A  11
ARG A  57
THR A  17
 None
 1.11A 4nx7A-2hi0A:
undetectable		 4nx7A-2hi0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		3 / 3 ASP A  11
ARG A  57
THR A  17
 None
 0.86A 4p3rA-2hi0A:
undetectable		 4p3rA-2hi0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		3 / 3 MET A 169
ASP A   9
PHE A   8
 None
NA  A 240 (-2.9A)
None
 0.95A 4xeyA-2hi0A:
undetectable		 4xeyA-2hi0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		3 / 3 MET A 169
ASP A   9
PHE A   8
 None
NA  A 240 (-2.9A)
None
 0.90A 4xeyB-2hi0A:
undetectable		 4xeyB-2hi0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE
(Lactobacillus
delbrueckii) 		5 / 12 VAL A 143
ILE A 187
VAL A 207
VAL A 130
PHE A   8
 None
 1.36A 6ap6A-2hi0A:
3.6		 6ap6A-2hi0A:
24.15