SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hi1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 PRO A 123
PRO A  18
THR A  43
ILE A  52
ALA A 302
 None
 1.49A 1fm4A-2hi1A:
undetectable		 1fm4A-2hi1A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 GLY A 289
ARG A 183
THR A 108
ILE A 119
PHE A 292
 None
 1.23A 1m2zD-2hi1A:
undetectable		 1m2zD-2hi1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 7 PHE A 252
ALA A 208
TYR A 267
PRO A 248
 None
 1.04A 1oniA-2hi1A:
undetectable
1oniB-2hi1A:
2.7		 1oniA-2hi1A:
18.77
1oniB-2hi1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 7 TYR A 267
PRO A 248
PHE A 252
ALA A 208
 None
 1.10A 1oniG-2hi1A:
2.7
1oniI-2hi1A:
undetectable		 1oniG-2hi1A:
18.77
1oniI-2hi1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 GLY A 289
ARG A 183
THR A 108
ILE A 119
PHE A 292
 None
 1.27A 1p93D-2hi1A:
undetectable		 1p93D-2hi1A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 7 GLU A  79
ALA A 100
LEU A 129
ALA A 132
 None
 1.09A 1sn0B-2hi1A:
undetectable
1sn0D-2hi1A:
undetectable		 1sn0B-2hi1A:
19.94
1sn0D-2hi1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 11 MET A 324
ALA A 317
SER A  26
LEU A  25
VAL A  22
 None
 1.18A 2c12B-2hi1A:
undetectable		 2c12B-2hi1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 6 GLY A  97
ALA A 100
LEU A  81
PRO A  13
 None
 0.99A 3bgdA-2hi1A:
undetectable		 3bgdA-2hi1A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 5 PRO A 203
ILE A 205
TYR A 243
TYR A 260
 None
 1.37A 3d9lA-2hi1A:
undetectable
3d9lY-2hi1A:
undetectable		 3d9lA-2hi1A:
16.23
3d9lY-2hi1A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 4 LEU A 228
MET A 262
ILE A 170
ASP A 269
 None
 1.11A 3hecA-2hi1A:
undetectable		 3hecA-2hi1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 PRO A  84
GLY A  39
ILE A  74
ARG A  46
LEU A  44
 None
 1.15A 3iv6C-2hi1A:
undetectable		 3iv6C-2hi1A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		3 / 3 ALA A  42
ARG A  46
LYS A  50
 None
 0.67A 3kp3B-2hi1A:
undetectable		 3kp3B-2hi1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 7 ILE A   8
LEU A  35
ALA A 120
ALA A  24
 None
 0.82A 4g77A-2hi1A:
2.1		 4g77A-2hi1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 8 ALA A 235
ASP A 261
ILE A 205
ILE A 164
 None
 0.90A 4kttB-2hi1A:
undetectable		 4kttB-2hi1A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 7 VAL A 155
ALA A 288
LEU A 322
ASP A 261
LEU A 195
 None
 1.41A 4l9iA-2hi1A:
undetectable		 4l9iA-2hi1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 GLY A 289
ARG A 183
THR A 108
ILE A 119
PHE A 292
 None
 1.26A 4p6xK-2hi1A:
undetectable		 4p6xK-2hi1A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 8 THR A   9
LEU A 143
LEU A 129
GLY A  11
 None
 0.88A 4r3aA-2hi1A:
undetectable		 4r3aA-2hi1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 VAL A 155
VAL A 187
GLY A 189
ALA A 191
LEU A 195
 None
 1.07A 4rrwC-2hi1A:
undetectable		 4rrwC-2hi1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 VAL A 155
VAL A 187
GLY A 189
ALA A 191
LEU A 195
 None
 1.07A 4rrwD-2hi1A:
undetectable		 4rrwD-2hi1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 VAL A 155
VAL A 187
GLY A 189
ALA A 191
LEU A 195
 None
 1.07A 4rrzC-2hi1A:
undetectable		 4rrzC-2hi1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 VAL A 155
VAL A 187
GLY A 189
ALA A 191
LEU A 195
 None
 1.07A 4rrzD-2hi1A:
undetectable		 4rrzD-2hi1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 GLY A  97
TYR A 101
ALA A  14
ALA A 128
ASN A 125
 None
 1.26A 4ymgA-2hi1A:
undetectable		 4ymgA-2hi1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		4 / 4 VAL A 116
ALA A 107
ILE A   8
THR A   9
 None
 1.06A 5e4dB-2hi1A:
undetectable		 5e4dB-2hi1A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 THR A 193
VAL A 198
ALA A 288
GLY A 289
ILE A 286
 None
 0.91A 5kb6B-2hi1A:
undetectable		 5kb6B-2hi1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 ALA A 100
ASN A 125
GLY A  90
ALA A  89
LEU A  47
 None
 1.29A 5x23A-2hi1A:
undetectable		 5x23A-2hi1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2
(Salmonella
enterica) 		5 / 12 VAL A 207
ILE A 164
ILE A 188
LEU A 195
ALA A 255
 None
 1.08A 6ajiA-2hi1A:
undetectable		 6ajiA-2hi1A:
17.19