SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hi6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		5 / 9 GLY A  93
ILE A  81
THR A  20
ILE A  30
VAL A  37
 None
 1.17A 2nnhB-2hi6A:
undetectable		 2nnhB-2hi6A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		5 / 12 ILE A   8
THR A   9
ILE A  81
ILE A  90
GLU A  87
 None
 1.30A 2yzqA-2hi6A:
undetectable		 2yzqA-2hi6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		4 / 5 ILE A  36
THR A  20
PHE A  55
PHE A  26
 None
 1.34A 3em0A-2hi6A:
undetectable		 3em0A-2hi6A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		4 / 4 ASP A  31
GLY A  29
LYS A  38
GLU A  39
 None
 1.34A 3hznD-2hi6A:
undetectable		 3hznD-2hi6A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		5 / 12 ILE A  81
LEU A  18
GLY A  64
PHE A  55
THR A  20
 None
 1.15A 5byjA-2hi6A:
undetectable		 5byjA-2hi6A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		4 / 5 ARG A  51
GLY A  15
GLU A  16
ARG A  72
 None
 0.97A 5cdqA-2hi6A:
undetectable
5cdqB-2hi6A:
undetectable
5cdqC-2hi6A:
undetectable		 5cdqA-2hi6A:
14.80
5cdqB-2hi6A:
22.66
5cdqC-2hi6A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		4 / 5 ARG A  51
GLY A  15
GLU A  16
ARG A  72
 None
 1.17A 5cdqR-2hi6A:
undetectable
5cdqS-2hi6A:
undetectable
5cdqT-2hi6A:
undetectable		 5cdqR-2hi6A:
14.80
5cdqS-2hi6A:
22.66
5cdqT-2hi6A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hi6 UPF0107 PROTEIN
AF0055
(Archaeoglobus
fulgidus) 		5 / 12 VAL A  48
PHE A  26
ILE A  99
LEU A 101
ILE A  90
 None
 0.92A 5mueA-2hi6A:
1.7		 5mueA-2hi6A:
20.09