SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		3 / 3 TRP X 188
ALA X 149
VAL X 209
 None
 0.85A 1bdwA-2hi8X:
undetectable
1bdwB-2hi8X:
undetectable		 1bdwA-2hi8X:
5.69
1bdwB-2hi8X:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		3 / 3 ARG X 189
THR X 143
VAL X 140
 None
 0.99A 1hxbA-2hi8X:
undetectable		 1hxbA-2hi8X:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		3 / 3 ALA X 358
VAL X 209
TRP X 188
 None
 0.80A 1tkqA-2hi8X:
undetectable		 1tkqA-2hi8X:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		3 / 3 MET X 161
ASN X 259
GLN X 262
 None
CA  X1017 (-3.3A)
CA  X1017 (-4.1A)
 0.93A 1xoqB-2hi8X:
undetectable		 1xoqB-2hi8X:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY X 332
GLY X 331
ALA X 348
ASN X 297
PHE X 158
 None
 1.09A 2dpmA-2hi8X:
undetectable		 2dpmA-2hi8X:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		3 / 3 ARG X 189
THR X 143
VAL X 140
 None
 0.76A 2q64A-2hi8X:
undetectable		 2q64A-2hi8X:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		3 / 3 ARG X 189
THR X 143
VAL X 140
 None
 0.79A 2qakA-2hi8X:
undetectable		 2qakA-2hi8X:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 4 GLY X 362
GLU X 130
ASP X 127
TYR X 217
 None
CA  X1016 (-3.3A)
None
None
 1.37A 2yvlC-2hi8X:
undetectable		 2yvlC-2hi8X:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 4 GLY X 362
GLU X 300
ASP X 127
TYR X 217
 None
CA  X1016 (-3.3A)
None
None
 1.49A 2yvlC-2hi8X:
undetectable		 2yvlC-2hi8X:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		5 / 7 LYS X 138
THR X 134
GLU X 135
VAL X 131
VAL X 281
 None
NAG  X   1 (-4.3A)
None
None
None
 1.44A 3em0B-2hi8X:
undetectable		 3em0B-2hi8X:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.31A 4v3wA-2hi8X:
undetectable
4v3wB-2hi8X:
undetectable		 4v3wA-2hi8X:
21.29
4v3wB-2hi8X:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		3 / 3 ASP X 304
ARG X 224
PRO X 226
 None
 0.99A 4wanC-2hi8X:
undetectable		 4wanC-2hi8X:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.31A 5uo9A-2hi8X:
undetectable
5uo9B-2hi8X:
undetectable		 5uo9A-2hi8X:
21.09
5uo9B-2hi8X:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.27A 5uo9C-2hi8X:
undetectable
5uo9D-2hi8X:
0.0		 5uo9C-2hi8X:
21.09
5uo9D-2hi8X:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 299
TRP X 231
TRP X 301
GLU X 300
 BR  X1001 ( 4.4A)
None
None
CA  X1016 (-3.3A)
 1.25A 5vv9A-2hi8X:
0.0
5vv9B-2hi8X:
0.0		 5vv9A-2hi8X:
21.27
5vv9B-2hi8X:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 299
TRP X 231
TRP X 301
GLU X 300
 BR  X1001 ( 4.4A)
None
None
CA  X1016 (-3.3A)
 1.24A 5vvaA-2hi8X:
undetectable
5vvaB-2hi8X:
undetectable		 5vvaA-2hi8X:
21.27
5vvaB-2hi8X:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 299
TRP X 231
TRP X 301
GLU X 300
 BR  X1001 ( 4.4A)
None
None
CA  X1016 (-3.3A)
 1.26A 6auuA-2hi8X:
undetectable
6auuB-2hi8X:
undetectable		 6auuA-2hi8X:
13.48
6auuB-2hi8X:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.27A 6av6A-2hi8X:
0.0
6av6B-2hi8X:
0.0		 6av6A-2hi8X:
13.64
6av6B-2hi8X:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens) 		4 / 7 TRP X 231
TRP X 301
GLU X 300
TRP X 299
 None
None
CA  X1016 (-3.3A)
BR  X1001 ( 4.4A)
 1.23A 6cieA-2hi8X:
0.0
6cieB-2hi8X:
0.0		 6cieA-2hi8X:
13.64
6cieB-2hi8X:
13.64