SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hi9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 8 ILE A 249
LEU A 363
LEU A 280
PHE A 275
 None
 0.84A 2vctA-2hi9A:
undetectable		 2vctA-2hi9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 8 ILE A 249
LEU A 363
LEU A 280
PHE A 275
 None
 0.87A 2vctB-2hi9A:
undetectable		 2vctB-2hi9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 8 ILE A 249
LEU A 363
LEU A 280
PHE A 275
 None
 0.86A 2vctC-2hi9A:
undetectable		 2vctC-2hi9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 6 THR A 116
ILE A 317
LEU A 122
THR A 138
 None
 0.83A 3deuB-2hi9A:
undetectable		 3deuB-2hi9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 12 VAL A 334
ILE A 289
ILE A 184
PHE A 372
ILE A 249
 None
 1.07A 4pd4C-2hi9A:
undetectable		 4pd4C-2hi9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 7 LYS A 187
GLU A 335
SER A 288
LYS A 286
 None
 1.22A 4tvtA-2hi9A:
undetectable		 4tvtA-2hi9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		3 / 3 THR A 141
HIS A 330
LEU A 168
 None
 0.80A 5axdA-2hi9A:
undetectable		 5axdA-2hi9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		3 / 3 THR A 141
HIS A 330
LEU A 168
 None
 0.80A 5axdC-2hi9A:
undetectable		 5axdC-2hi9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 5 SER A 252
ARG A 362
GLU A 281
ARG A 367
 None
 1.07A 5cdqA-2hi9A:
undetectable
5cdqB-2hi9A:
undetectable
5cdqC-2hi9A:
undetectable		 5cdqA-2hi9A:
21.15
5cdqB-2hi9A:
21.35
5cdqC-2hi9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 7 ILE A 304
GLY A 303
ASP A  32
PHE A  31
 None
 1.13A 5hieA-2hi9A:
undetectable		 5hieA-2hi9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		4 / 7 SER A  52
ALA A 332
ILE A 165
LEU A 168
 None
 0.97A 5te8C-2hi9A:
undetectable		 5te8C-2hi9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 12 THR A 141
VAL A 181
TYR A 183
THR A 161
GLU A 327
 None
 1.24A 5v1tA-2hi9A:
undetectable		 5v1tA-2hi9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 7 GLY A  75
LEU A  76
LEU A 381
LEU A 299
ILE A  46
 None
 1.37A 5vkqA-2hi9A:
undetectable
5vkqB-2hi9A:
undetectable		 5vkqA-2hi9A:
11.68
5vkqB-2hi9A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		3 / 3 SER A  61
HIS A  89
TYR A 134
 None
 1.03A 5y2tA-2hi9A:
undetectable		 5y2tA-2hi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens) 		5 / 12 PHE A 115
ALA A 113
ALA A  40
ALA A  36
LEU A 299
 None
 1.34A 6aycA-2hi9A:
undetectable		 6aycA-2hi9A:
13.51