SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLY A 198
LEU A 232
GLY A 223
PHE A 239
SER A 235
 None
 1.08A 1fduA-2higA:
3.9		 1fduA-2higA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 8 GLY A 123
ILE A 124
ILE A 116
ILE A 102
 None
 0.63A 1hshD-2higA:
undetectable		 1hshD-2higA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 8 ILE A 208
LEU A 185
PHE A 135
GLY A 134
 None
 1.04A 1os6A-2higA:
undetectable		 1os6A-2higA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLY A 204
ALA A 205
GLY A 197
ALA A 430
ILE A 427
 None
 0.92A 1rl8A-2higA:
undetectable		 1rl8A-2higA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 9 THR A 227
LEU A 232
ALA A 416
LEU A 398
GLU A 405
 None
 1.30A 2azqA-2higA:
undetectable		 2azqA-2higA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLY A 277
SER A 233
CYH A 293
ALA A 280
ALA A 284
 None
 1.20A 2bm9D-2higA:
undetectable		 2bm9D-2higA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 7 GLY A 106
GLY A 107
VAL A 103
SER A 172
 None
 0.69A 2oa1B-2higA:
undetectable		 2oa1B-2higA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 7 TYR A 127
PRO A  95
HIS A  92
TYR A  39
 None
 1.18A 2ombC-2higA:
undetectable
2ombD-2higA:
undetectable		 2ombC-2higA:
18.24
2ombD-2higA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 7 VAL A 182
ALA A 212
PHE A 135
THR A 195
 None
 1.06A 2q6oA-2higA:
undetectable		 2q6oA-2higA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 8 SER A 172
THR A 195
LEU A 206
THR A 167
 None
 1.12A 2v0zO-2higA:
undetectable		 2v0zO-2higA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 10 LEU A 185
VAL A 190
GLY A 189
LEU A 142
SER A 143
 None
 0.97A 2v3kA-2higA:
undetectable		 2v3kA-2higA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 VAL A 403
ALA A 406
ALA A  85
VAL A 132
ILE A 102
 None
 1.13A 3czhA-2higA:
undetectable		 3czhA-2higA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLY A 204
ALA A 205
VAL A 196
GLY A 197
ILE A 427
 None
 0.90A 3ekqA-2higA:
undetectable		 3ekqA-2higA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLN A 202
PHE A 239
VAL A 115
LEU A 112
THR A 104
 None
 1.29A 3elzA-2higA:
undetectable		 3elzA-2higA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLY A 223
VAL A 221
GLY A 412
GLY A 197
ILE A 427
 None
 0.90A 3ku1A-2higA:
2.1		 3ku1A-2higA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLY A 223
VAL A 221
GLY A 412
GLY A 198
ILE A 427
 None
 0.92A 3ku1A-2higA:
2.1		 3ku1A-2higA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 GLY A 223
VAL A 221
GLY A 412
GLY A 198
ILE A 427
 None
 0.94A 3ku1C-2higA:
2.1		 3ku1C-2higA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		3 / 3 GLY A 197
ILE A 116
VAL A 115
 None
 0.35A 3nv6A-2higA:
undetectable		 3nv6A-2higA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 8 ILE A 208
LEU A 185
PHE A 135
GLY A 134
 None
 1.04A 3selX-2higA:
undetectable		 3selX-2higA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 6 ILE A 208
LEU A 185
PHE A 135
GLY A 134
 None
 1.05A 3sj1X-2higA:
undetectable		 3sj1X-2higA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 LEU A 353
CYH A 319
LEU A 361
VAL A 357
HIS A 315
 None
 1.28A 3sp9A-2higA:
undetectable		 3sp9A-2higA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 LEU A 353
CYH A 319
LEU A 361
VAL A 357
HIS A 315
 None
 1.25A 3sp9B-2higA:
undetectable		 3sp9B-2higA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 6 LEU A 309
ALA A 290
THR A 451
LEU A 294
 None
 0.94A 3t3zA-2higA:
undetectable		 3t3zA-2higA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 6 LEU A 309
ALA A 290
THR A 451
LEU A 294
 None
 0.89A 3t3zB-2higA:
undetectable		 3t3zB-2higA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 6 LEU A 309
ALA A 290
THR A 451
LEU A 294
 None
 0.97A 3t3zD-2higA:
undetectable		 3t3zD-2higA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 TYR A  61
LEU A 206
PHE A 234
LEU A 424
ALA A 410
 None
 1.16A 3vw7A-2higA:
undetectable		 3vw7A-2higA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 7 ILE A 208
LEU A 185
PHE A 135
GLY A 134
 None
 0.98A 4hajA-2higA:
undetectable		 4hajA-2higA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 7 ILE A 208
LEU A 185
PHE A 135
GLY A 134
 None
 1.04A 4hc3A-2higA:
undetectable		 4hc3A-2higA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 4 ILE A 292
ASN A 291
ILE A 450
VAL A 447
 None
 1.30A 4uy87-2higA:
undetectable		 4uy87-2higA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 6 LEU A 232
ASP A 229
ILE A 415
PRO A 110
 None
 1.08A 4xi3C-2higA:
undetectable		 4xi3C-2higA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 9 SER A 209
ALA A 212
LEU A  34
ILE A 192
 None
 0.86A 4xtaA-2higA:
undetectable		 4xtaA-2higA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 7 VAL A 115
ILE A 119
PHE A 194
VAL A 196
 None
 0.77A 5bmvC-2higA:
undetectable		 5bmvC-2higA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 PHE A 194
GLY A 204
ILE A 208
ILE A 415
ALA A 406
 None
 1.06A 5e72A-2higA:
undetectable		 5e72A-2higA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 SER A 171
GLY A 106
GLY A 197
VAL A 196
THR A 195
 None
 1.19A 5o4yD-2higA:
undetectable
5o4yE-2higA:
undetectable		 5o4yD-2higA:
2.67
5o4yE-2higA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		4 / 6 LEU A 309
VAL A 357
LEU A 353
VAL A 373
 None
 0.94A 5x7zA-2higA:
undetectable		 5x7zA-2higA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 MET A 272
GLY A 273
GLY A 326
ASP A 229
ILE A 228
 None
 1.14A 6b3aA-2higA:
undetectable		 6b3aA-2higA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2hig 6-PHOSPHO-1-FRUCTOKI
NASE
(Trypanosoma
brucei) 		5 / 12 MET A 272
GLY A 273
GLY A 326
ASP A 229
ILE A 228
 None
 1.12A 6b3bA-2higA:
undetectable		 6b3bA-2higA:
21.91