SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 GLY A  25
PHE A  26
SER A 124
MET A 125
HIS A 355
 None
 0.65A 1a8uA-2hihA:
14.0		 1a8uA-2hihA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 GLY A  25
PHE A  26
SER A 124
MET A 125
HIS A 355
 None
 0.63A 1a8uB-2hihA:
14.0		 1a8uB-2hihA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 LEU A 158
GLU A 144
LEU A 137
GLU A  72
ALA A  74
 None
None
None
ZN  A 601 (-2.0A)
None
 1.36A 1ie4A-2hihA:
undetectable
1ie4C-2hihA:
undetectable		 1ie4A-2hihA:
14.02
1ie4C-2hihA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 LEU A 158
GLU A 144
LEU A 137
LEU A 132
GLU A  72
 None
None
None
None
ZN  A 601 (-2.0A)
 1.22A 1ie4A-2hihA:
undetectable
1ie4C-2hihA:
undetectable		 1ie4A-2hihA:
14.02
1ie4C-2hihA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 9 HIS A 355
LEU A 316
HIS A 123
PHE A  26
GLY A  25
 None
 1.48A 1mjlA-2hihA:
undetectable
1mjlB-2hihA:
undetectable		 1mjlA-2hihA:
12.91
1mjlB-2hihA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 GLY A 245
THR A 244
ALA A 254
GLY A 187
SER A 183
 None
 1.12A 1nbiC-2hihA:
undetectable		 1nbiC-2hihA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 GLY A 245
THR A 244
ALA A 254
GLY A 187
SER A 183
 None
 1.14A 1nbiD-2hihA:
undetectable		 1nbiD-2hihA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 LEU A 132
GLU A  72
LEU A 158
GLU A 144
LEU A 137
 None
ZN  A 601 (-2.0A)
None
None
None
 1.05A 1sn5B-2hihA:
undetectable
1sn5D-2hihA:
undetectable		 1sn5B-2hihA:
16.76
1sn5D-2hihA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 LEU A 158
GLU A 144
LEU A 137
LEU A 132
GLU A  72
 None
None
None
None
ZN  A 601 (-2.0A)
 1.07A 1sn5B-2hihA:
undetectable
1sn5D-2hihA:
undetectable		 1sn5B-2hihA:
16.76
1sn5D-2hihA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 4 TYR A 136
LEU A 137
LEU A 158
HIS A  71
 None
 1.42A 2x7hB-2hihA:
undetectable		 2x7hB-2hihA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 PHE A 159
GLY A  89
ALA A  90
TYR A 147
ASP A  87
 None
 1.48A 2xtkB-2hihA:
undetectable		 2xtkB-2hihA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 7 GLY A 253
LYS A 256
ASP A 243
TYR A 247
 None
None
ZN  A 601 (-2.2A)
None
 0.94A 3arrA-2hihA:
undetectable		 3arrA-2hihA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 7 GLY A 253
LYS A 256
ASP A 243
TYR A 247
 None
None
ZN  A 601 (-2.2A)
None
 0.93A 3aruA-2hihA:
undetectable		 3aruA-2hihA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 THR A 250
GLY A 179
ASN A 178
ASN A 258
GLY A 187
 None
 1.17A 3eeyA-2hihA:
undetectable		 3eeyA-2hihA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 THR A 250
GLY A 179
ASN A 178
ASN A 258
GLY A 187
 None
 1.16A 3eeyH-2hihA:
undetectable		 3eeyH-2hihA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 THR A 250
GLY A 179
ASN A 178
ASN A 258
GLY A 187
 None
 1.17A 3eeyI-2hihA:
undetectable		 3eeyI-2hihA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 8 GLY A 253
ALA A 254
GLY A 245
LEU A 246
VAL A 317
 None
 1.45A 3em6A-2hihA:
undetectable		 3em6A-2hihA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 ASP A  87
VAL A  86
GLY A  89
TYR A 136
HIS A  71
 None
 1.36A 3hgiA-2hihA:
undetectable		 3hgiA-2hihA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 TYR A  40
GLY A 127
GLY A 126
ALA A 174
PRO A 325
 None
 1.01A 3jb2A-2hihA:
undetectable		 3jb2A-2hihA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 LEU A 316
ALA A 174
SER A 124
HIS A 123
 None
 0.93A 3kp6A-2hihA:
undetectable		 3kp6A-2hihA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 4 GLY A 122
GLY A 127
THR A 129
LEU A  77
 None
 0.92A 3si7C-2hihA:
undetectable
3si7D-2hihA:
undetectable		 3si7C-2hihA:
21.56
3si7D-2hihA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 LEU A 133
VAL A  64
TYR A  79
LEU A 158
 None
 1.02A 3v81A-2hihA:
undetectable		 3v81A-2hihA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 LEU A 133
VAL A  64
TYR A  79
LEU A 158
 None
 1.05A 3v81C-2hihA:
undetectable		 3v81C-2hihA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 ALA A 254
TRP A 310
SER A 326
ASN A 178
GLY A 253
 None
 1.50A 3vwqA-2hihA:
undetectable		 3vwqA-2hihA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 VAL A  33
ALA A  35
SER A  65
PHE A  26
VAL A  30
 None
 1.47A 4eilB-2hihA:
undetectable		 4eilB-2hihA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 VAL A  33
ALA A  35
SER A  65
PHE A  26
VAL A  30
 None
 1.48A 4eilD-2hihA:
undetectable		 4eilD-2hihA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 6 ASP A 357
GLY A 315
PRO A 176
THR A 175
 CA  A 603 (-2.3A)
None
None
None
 1.10A 4l1aB-2hihA:
undetectable		 4l1aB-2hihA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 5 TYR A 377
GLY A 122
GLU A  61
VAL A 108
 None
 1.12A 4nkvD-2hihA:
undetectable		 4nkvD-2hihA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 LEU A 133
VAL A  64
TYR A  79
LEU A 158
 None
 1.00A 4puoC-2hihA:
undetectable		 4puoC-2hihA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 LEU A 133
VAL A  64
TYR A  79
LEU A 158
 None
 1.04A 4pwdC-2hihA:
undetectable		 4pwdC-2hihA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 LEU A 133
VAL A  64
TYR A  79
LEU A 158
 None
 1.15A 4q0bA-2hihA:
undetectable		 4q0bA-2hihA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 THR A 172
GLU A 134
PHE A 120
GLY A 122
 None
 0.81A 4r3aA-2hihA:
undetectable		 4r3aA-2hihA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 6 GLU A 372
PHE A 376
PHE A 358
HIS A 368
 None
 1.05A 4uciA-2hihA:
undetectable		 4uciA-2hihA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 7 GLU A 372
PHE A 376
PHE A 358
HIS A 368
 None
 1.08A 4uciB-2hihA:
undetectable		 4uciB-2hihA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_1
(PROLINE--TRNA LIGASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 4 THR A 261
GLU A 328
THR A 172
HIS A 177
 None
 1.48A 4ydqA-2hihA:
2.0		 4ydqA-2hihA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 12 GLY A 179
SER A 183
SER A 322
ALA A 254
ASN A 258
 None
 1.38A 4ymgB-2hihA:
undetectable		 4ymgB-2hihA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 6 ALA A 182
SER A 183
SER A 124
ASP A 314
 None
 1.07A 5c6pA-2hihA:
undetectable		 5c6pA-2hihA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_1
(AMINOACYL-TRNA
SYNTHETASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 4 THR A 261
GLU A 328
THR A 172
HIS A 177
 None
 1.26A 5f9zA-2hihA:
0.0		 5f9zA-2hihA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_1
(AMINOACYL-TRNA
SYNTHETASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 4 THR A 261
GLU A 328
THR A 172
HIS A 177
 None
 1.26A 5f9zB-2hihA:
0.3		 5f9zB-2hihA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 6 ASP A 314
ASP A 307
ARG A 311
ASN A 313
 None
 1.22A 5l6eA-2hihA:
undetectable		 5l6eA-2hihA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		5 / 10 LEU A 384
ILE A 380
PHE A  22
VAL A  21
PRO A 117
 None
 1.28A 5m0oA-2hihA:
undetectable		 5m0oA-2hihA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2hih LIPASE 46 KDA FORM
(Staphylococcus
hyicus) 		4 / 8 THR A  27
GLY A  28
GLY A  25
SER A 124
 None
 0.73A 5vw9A-2hihA:
undetectable		 5vw9A-2hihA:
23.28