SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2him'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 12 ILE A  75
GLY A  84
VAL A 112
SER A   5
GLY A 109
 None
 1.08A 1nbiA-2himA:
undetectable		 1nbiA-2himA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 12 ILE A  75
GLY A  84
VAL A 112
SER A   5
GLY A 109
 None
 1.09A 1nbiB-2himA:
undetectable		 1nbiB-2himA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 9 LEU A  35
PHE A  41
GLY A 128
THR A 115
LEU A 136
 None
 1.05A 1nr6A-2himA:
undetectable		 1nr6A-2himA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.86A 1ya4B-2himA:
2.0		 1ya4B-2himA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 4 LEU A  35
PRO A  26
ILE A  15
LEU A 121
 None
 0.98A 1ya4C-2himA:
undetectable		 1ya4C-2himA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		6 / 12 GLY A 158
GLY A 332
LEU A 155
LEU A 180
VAL A 114
THR A 115
 None
 1.43A 2nyuB-2himA:
undetectable		 2nyuB-2himA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		6 / 12 LEU A 149
ALA A 135
ASN A 134
ILE A 130
GLY A 128
ILE A  15
 None
 1.39A 2q64B-2himA:
undetectable		 2q64B-2himA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 9 ALA A  95
ALA A  98
SER A 102
PHE A 103
ALA A 304
 None
 1.22A 2vh3A-2himA:
undetectable		 2vh3A-2himA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 11 ILE A 113
ALA A  98
PHE A 151
ILE A  15
VAL A  86
 None
 1.16A 2w3aA-2himA:
undetectable		 2w3aA-2himA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 7 LYS A   3
ARG A  43
VAL A   8
ILE A  51
 None
 0.95A 3gp0A-2himA:
undetectable		 3gp0A-2himA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		3 / 3 GLY A 245
ILE A 295
VAL A 294
 None
 0.51A 3nv6A-2himA:
undetectable		 3nv6A-2himA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 11 THR A 307
ARG A 331
LEU A 330
GLN A 315
ILE A 207
 None
 1.48A 3qelA-2himA:
4.2
3qelB-2himA:
3.5		 3qelA-2himA:
22.54
3qelB-2himA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 7 TRP A  68
ILE A  71
ILE A  75
VAL A 112
 None
 0.59A 3r9vA-2himA:
undetectable
3r9vB-2himA:
undetectable		 3r9vA-2himA:
22.31
3r9vB-2himA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 12 LEU A 132
ILE A  87
VAL A   8
PHE A  49
LEU A 108
 None
 1.20A 3w67D-2himA:
undetectable		 3w67D-2himA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 12 ILE A 322
LEU A 257
ILE A 212
ILE A 238
VAL A 278
 None
 0.96A 3w68C-2himA:
undetectable		 3w68C-2himA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 7 ASN A 250
ALA A 252
VAL A 226
ARG A 227
 None
 0.92A 4ijiH-2himA:
undetectable		 4ijiH-2himA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 8 GLY A 128
THR A 115
ASN A 131
PHE A 151
 None
 1.06A 4m5mA-2himA:
undetectable		 4m5mA-2himA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		3 / 3 ASP A  74
HIS A  78
LYS A  76
 None
 0.85A 4qzuD-2himA:
undetectable		 4qzuD-2himA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 11 THR A 307
ARG A 331
LEU A 330
GLN A 315
ILE A 207
 None
 1.45A 5ewjA-2himA:
3.9
5ewjB-2himA:
3.5		 5ewjA-2himA:
22.88
5ewjB-2himA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 12 THR A 307
ARG A 331
LEU A 330
GLN A 315
ILE A 207
 None
 1.43A 5ewjC-2himA:
4.2
5ewjD-2himA:
3.4		 5ewjC-2himA:
22.88
5ewjD-2himA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 10 GLY A  90
GLY A 116
SER A 117
LEU A  31
TYR A  10
 ASN  A6001 ( 3.1A)
None
None
None
None
 1.23A 5hwkA-2himA:
undetectable		 5hwkA-2himA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		5 / 10 GLY A  90
GLY A 116
SER A 117
LEU A  31
TYR A  10
 ASN  A6001 ( 3.1A)
None
None
None
None
 1.22A 5hwkB-2himA:
undetectable		 5hwkB-2himA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 5 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
None
None
ASP  A7001 ( 3.5A)
 0.91A 5x7pA-2himA:
3.1		 5x7pA-2himA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2him L-ASPARAGINASE 1
(Escherichia
coli) 		4 / 6 TYR A  10
TYR A  54
GLY A  12
GLY A  13
 None
None
None
ASP  A7001 ( 3.5A)
 0.92A 5x7pB-2himA:
2.9		 5x7pB-2himA:
15.35