SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2his'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		5 / 10 PHE A 202
VAL A 173
VAL A 200
VAL A 227
ASN A 181
 None
 1.12A 1fe2A-2hisA:
undetectable		 1fe2A-2hisA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		3 / 3 ASP A 296
THR A 276
GLU A  26
 None
 0.78A 1pj7A-2hisA:
undetectable		 1pj7A-2hisA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		5 / 10 VAL A 294
GLY A 274
LEU A 293
TYR A 305
ILE A  32
 None
 1.39A 1sq5D-2hisA:
0.0		 1sq5D-2hisA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		4 / 6 PHE A 115
PRO A  21
ALA A  42
ALA A  67
 None
 0.92A 2vcvB-2hisA:
undetectable		 2vcvB-2hisA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		3 / 3 TRP A 281
VAL A 272
TRP A 273
 GLC  A 602 ( 3.4A)
None
GLC  A 602 ( 4.1A)
 1.16A 3zq8C-2hisA:
undetectable
3zq8D-2hisA:
undetectable		 3zq8C-2hisA:
9.76
3zq8D-2hisA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		4 / 8 ASP A  34
PHE A  17
VAL A  40
LEU A  24
 None
 1.11A 4f5zA-2hisA:
undetectable		 4f5zA-2hisA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		3 / 3 GLU A  36
TRP A 295
LYS A   1
 None
 0.85A 4k7aA-2hisA:
undetectable		 4k7aA-2hisA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		4 / 4 ALA A 153
ALA A 156
ALA A 157
ALA A 160
 None
 0.12A 4oadA-2hisA:
undetectable		 4oadA-2hisA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		3 / 3 SER A 280
ASP A 277
GLN A 250
 None
 0.65A 4oltA-2hisA:
undetectable
4oltB-2hisA:
undetectable		 4oltA-2hisA:
23.22
4oltB-2hisA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		3 / 3 GLN A 250
SER A 280
ASP A 277
 None
 0.62A 4qwpA-2hisA:
undetectable
4qwpB-2hisA:
undetectable		 4qwpA-2hisA:
23.22
4qwpB-2hisA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		6 / 12 GLY A 274
VAL A 294
ALA A 304
LEU A 206
ILE A 236
PHE A  15
 None
 1.43A 5hieA-2hisA:
undetectable		 5hieA-2hisA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		4 / 8 ILE A 207
GLN A 250
TYR A 254
VAL A 282
 None
 1.14A 5vlmF-2hisA:
undetectable		 5vlmF-2hisA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2his CELLULOMONAS FIMI
FAMILY 10
BETA-1,4-GLYCANASE
(Cellulomonas
fimi) 		4 / 8 VAL A 285
GLN A 203
ASN A 205
GLU A 233
 None
GLC  A 602 (-3.1A)
GLC  A 602 (-3.8A)
GLC  A 602 ( 1.9A)
 1.05A 6hzpA-2hisA:
undetectable		 6hzpA-2hisA:
23.36