SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hiv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  30
VAL A  42
ILE A  44
VAL A 121
ILE A  37
 None
 1.14A 1gebA-2hivA:
undetectable		 1gebA-2hivA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A 206
LEU A 207
ILE A  44
THR A  36
ILE A  37
 None
 1.04A 1hzeA-2hivA:
0.0
1hzeB-2hivA:
0.0		 1hzeA-2hivA:
11.21
1hzeB-2hivA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 9 THR A  36
ILE A  37
ASP A 206
LEU A 207
ILE A  44
 None
 1.04A 1hzeA-2hivA:
0.0
1hzeB-2hivA:
0.0		 1hzeA-2hivA:
11.21
1hzeB-2hivA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A 504
GLU A 524
PHE A 479
ARG A 512
 None
 1.04A 1oniA-2hivA:
undetectable
1oniC-2hivA:
undetectable		 1oniA-2hivA:
13.06
1oniC-2hivA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 7 ILE A 504
GLU A 524
PHE A 479
ARG A 512
 None
 1.16A 1oniD-2hivA:
undetectable
1oniE-2hivA:
undetectable		 1oniD-2hivA:
13.06
1oniE-2hivA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 6 VAL A 411
GLU A 406
ARG A 402
PHE A 399
 None
 0.78A 1s8fB-2hivA:
undetectable		 1s8fB-2hivA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 TYR A 201
THR A 178
LEU A  30
MET A 183
 None
 1.43A 1uw6D-2hivA:
undetectable
1uw6E-2hivA:
undetectable		 1uw6D-2hivA:
17.33
1uw6E-2hivA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 TYR A 201
THR A 178
LEU A  30
MET A 183
 None
 1.42A 1uw6G-2hivA:
undetectable
1uw6H-2hivA:
undetectable		 1uw6G-2hivA:
17.33
1uw6H-2hivA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 TYR A 201
THR A 178
LEU A  30
MET A 183
 None
 1.41A 1uw6P-2hivA:
undetectable
1uw6Q-2hivA:
undetectable		 1uw6P-2hivA:
17.33
1uw6Q-2hivA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A  30
MET A 183
TYR A 201
THR A 178
 None
 1.39A 1uw6P-2hivA:
undetectable
1uw6T-2hivA:
undetectable		 1uw6P-2hivA:
17.33
1uw6T-2hivA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 8 GLY A 190
GLY A 189
GLY A 188
SER A 192
ALA A 193
 None
 1.01A 1yajC-2hivA:
2.3		 1yajC-2hivA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A 170
ILE A  44
ILE A   6
ALA A   7
 None
 0.76A 2i2zA-2hivA:
undetectable		 2i2zA-2hivA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 4 LEU A 170
ILE A  44
ILE A   6
ALA A   7
 None
 0.77A 2i30A-2hivA:
undetectable		 2i30A-2hivA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A 222
GLY A 188
ALA A 184
ASP A 181
ALA A 200
ILE A 197
 None
 1.49A 2nmzA-2hivA:
undetectable		 2nmzA-2hivA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A 207
LEU A  26
VAL A 172
GLY A 173
 None
 0.96A 2po5A-2hivA:
undetectable		 2po5A-2hivA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A 561
THR A 575
THR A 537
 None
 0.66A 3k2hB-2hivA:
undetectable		 3k2hB-2hivA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A  16
GLN A  21
ALA A  24
LEU A  25
 None
 0.50A 3ozwA-2hivA:
undetectable		 3ozwA-2hivA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 7 GLU A 406
TYR A 259
HIS A 387
VAL A 413
 None
 0.96A 4a97D-2hivA:
undetectable		 4a97D-2hivA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 6 GLU A 406
TYR A 259
HIS A 387
VAL A 413
 None
 1.04A 4a97E-2hivA:
undetectable		 4a97E-2hivA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A 472
ARG A 512
SER A 478
 None
 1.04A 4dr2I-2hivA:
undetectable
4dr2J-2hivA:
undetectable		 4dr2I-2hivA:
12.54
4dr2J-2hivA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A 472
ARG A 512
SER A 478
 None
 1.20A 4lf7I-2hivA:
undetectable
4lf7J-2hivA:
undetectable		 4lf7I-2hivA:
12.54
4lf7J-2hivA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A 472
ARG A 512
SER A 478
 None
 1.20A 4lf8I-2hivA:
undetectable
4lf8J-2hivA:
undetectable		 4lf8I-2hivA:
12.54
4lf8J-2hivA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 6 ASP A 176
ASP A  52
SER A 279
ALA A 205
 None
 1.23A 4nedA-2hivA:
undetectable		 4nedA-2hivA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A 349
ASP A 258
ILE A 306
 None
 0.49A 4xi3D-2hivA:
undetectable		 4xi3D-2hivA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A  70
GLY A  92
ALA A  95
GLU A 167
THR A  74
 None
 1.30A 4xt8A-2hivA:
undetectable		 4xt8A-2hivA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A 229
LEU A 349
ILE A 307
VAL A 296
VAL A 292
 None
 1.13A 4y0qA-2hivA:
undetectable		 4y0qA-2hivA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 TYR A 125
TRP A  50
TYR A  43
LEU A  54
 None
 1.32A 5kxiA-2hivA:
undetectable
5kxiB-2hivA:
undetectable		 5kxiA-2hivA:
20.42
5kxiB-2hivA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		4 / 8 TYR A 125
TRP A  50
TYR A  43
LEU A  54
 None
 1.32A 5kxiD-2hivA:
undetectable
5kxiE-2hivA:
2.0		 5kxiD-2hivA:
20.42
5kxiE-2hivA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 8 VAL A 382
ILE A 307
LEU A 349
ILE A 268
ILE A 275
 None
 1.18A 5numA-2hivA:
undetectable		 5numA-2hivA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A 124
LEU A  66
LEU A 151
GLY A  47
LEU A 170
 None
 0.97A 6b0cD-2hivA:
undetectable		 6b0cD-2hivA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2hiv THERMOSTABLE DNA
LIGASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A 124
LEU A  66
LEU A 151
GLY A  47
LEU A 170
 None
 1.08A 6b0iB-2hivA:
undetectable		 6b0iB-2hivA:
9.77