SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hiy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 2hiy HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 154
TYR A 150
ILE A 135
ILE A 165
 GOL  A8002 ( 4.5A)
None
None
None
 0.96A 2q8hA-2hiyA:
undetectable		 2q8hA-2hiyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2hiy HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 LEU A 128
LEU A 103
ALA A 149
LEU A 154
PHE A 159
 None
None
None
GOL  A8002 ( 4.5A)
None
 1.20A 2vcvI-2hiyA:
undetectable		 2vcvI-2hiyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2hiy HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ALA A   5
LEU A   6
LEU A  24
ARG A  25
LEU A  28
 None
 0.88A 4wg0C-2hiyA:
undetectable
4wg0D-2hiyA:
undetectable
4wg0E-2hiyA:
undetectable		 4wg0C-2hiyA:
5.62
4wg0D-2hiyA:
5.62
4wg0E-2hiyA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2hiy HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ALA A   5
LEU A   6
LEU A  24
ARG A  25
LEU A  28
 None
 0.91A 4wg0E-2hiyA:
undetectable
4wg0F-2hiyA:
undetectable
4wg0G-2hiyA:
undetectable		 4wg0E-2hiyA:
5.62
4wg0F-2hiyA:
5.62
4wg0G-2hiyA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2hiy HYPOTHETICAL PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 TYR A   4
LYS A  53
LEU A  60
GLU A 107
 None
 1.40A 6cbdA-2hiyA:
1.3		 6cbdA-2hiyA:
12.29