SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 9 LEU A 304
ILE A 286
VAL A 268
GLY A 244
ALA A 263
 None
 1.18A 1e7aA-2hj9A:
undetectable		 1e7aA-2hj9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 ARG A 351
THR A 307
VAL A 343
 None
 1.01A 1hxbA-2hj9A:
undetectable		 1hxbA-2hj9A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 THR A 307
GLY A 291
GLY A 183
LEU A 187
 None
 0.75A 1jhqA-2hj9A:
undetectable		 1jhqA-2hj9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 THR A 307
GLY A 291
GLY A 183
LEU A 187
 None
 0.74A 1jhvA-2hj9A:
undetectable		 1jhvA-2hj9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 10 ILE A 261
VAL A 268
TYR A 235
GLY A 244
LEU A 252
 None
 1.34A 1s1uA-2hj9A:
undetectable		 1s1uA-2hj9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 12 VAL A 176
GLY A 177
LEU A  48
THR A 315
ALA A 318
 None
 0.66A 2egvA-2hj9A:
undetectable		 2egvA-2hj9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 12 VAL A 176
GLY A 177
LEU A  48
THR A 315
ALA A 318
 None
 0.68A 2egvB-2hj9A:
undetectable		 2egvB-2hj9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 ARG A 351
THR A 307
VAL A 343
 None
 0.89A 2qakA-2hj9A:
undetectable		 2qakA-2hj9A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 THR A  45
SER A  49
ALA A 318
PRO A 333
 None
 1.11A 2v41G-2hj9A:
undetectable
2v41H-2hj9A:
undetectable		 2v41G-2hj9A:
19.13
2v41H-2hj9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 12 PHE A 178
GLY A 291
GLY A 290
ALA A 359
ASP A 313
 None
None
AI2  A 501 ( 4.6A)
None
None
 1.22A 3i5uA-2hj9A:
2.4		 3i5uA-2hj9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 SER A 207
ASP A 136
ASN A 159
 None
None
AI2  A 501 (-3.3A)
 1.01A 3lsfB-2hj9A:
3.2
3lsfE-2hj9A:
2.5		 3lsfB-2hj9A:
20.11
3lsfE-2hj9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 ASP A 136
ASN A 159
SER A 207
 None
AI2  A 501 (-3.3A)
None
 0.99A 3lsfB-2hj9A:
3.2
3lsfE-2hj9A:
2.6		 3lsfB-2hj9A:
20.11
3lsfE-2hj9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 ASP A 136
ASN A 159
SER A 207
 None
AI2  A 501 (-3.3A)
None
 0.94A 3lslA-2hj9A:
undetectable
3lslD-2hj9A:
2.8		 3lslA-2hj9A:
20.40
3lslD-2hj9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 SER A 207
ASP A 136
ASN A 159
 None
None
AI2  A 501 (-3.3A)
 0.93A 3lslA-2hj9A:
1.6
3lslD-2hj9A:
2.7		 3lslA-2hj9A:
20.40
3lslD-2hj9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 4 SER A 363
GLY A 290
GLU A 186
 None
AI2  A 501 ( 4.6A)
None
 0.64A 3raeA-2hj9A:
undetectable
3raeC-2hj9A:
3.5		 3raeA-2hj9A:
21.43
3raeC-2hj9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 GLY A 244
ALA A 275
LYS A 249
GLU A 278
 None
 0.87A 3u9hA-2hj9A:
undetectable		 3u9hA-2hj9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 GLY A 244
ALA A 275
LYS A 249
GLU A 278
 None
 0.85A 3u9hB-2hj9A:
undetectable		 3u9hB-2hj9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 9 THR A 134
ILE A 211
HIS A 180
ASN A  85
TYR A  73
 None
AI2  A 501 ( 4.6A)
None
None
None
 1.33A 3upwA-2hj9A:
2.6		 3upwA-2hj9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 PHE A 178
HIS A 180
GLY A 177
GLY A 291
 None
 0.97A 3v3nB-2hj9A:
3.0		 3v3nB-2hj9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 PHE A 178
HIS A 180
GLY A 177
GLY A 291
 None
 0.97A 3v3nC-2hj9A:
2.8		 3v3nC-2hj9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 PHE A 178
HIS A 180
GLY A 177
GLY A 292
 None
 1.01A 3v3nC-2hj9A:
2.8		 3v3nC-2hj9A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 12 GLY A 183
PHE A 340
VAL A 176
TYR A  31
SER A  49
 None
 1.49A 4a83A-2hj9A:
0.0		 4a83A-2hj9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 8 GLY A 244
ALA A 275
LYS A 249
GLU A 278
 None
 0.79A 4bjcA-2hj9A:
undetectable		 4bjcA-2hj9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		5 / 12 THR A 138
VAL A 164
ASP A 179
ASP A 213
VAL A 214
 None
 1.46A 4df3A-2hj9A:
4.4		 4df3A-2hj9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 6 TYR A 210
VAL A 164
TYR A  28
TRP A 167
 None
 1.40A 4jtrB-2hj9A:
2.9		 4jtrB-2hj9A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 4 SER A 363
GLY A 290
GLU A 186
 None
AI2  A 501 ( 4.6A)
None
 0.56A 4juoA-2hj9A:
undetectable
4juoC-2hj9A:
2.9		 4juoA-2hj9A:
21.43
4juoC-2hj9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 ARG A 139
HIS A 140
SER A 117
 None
 0.84A 4mjwA-2hj9A:
undetectable
4mjwB-2hj9A:
undetectable		 4mjwA-2hj9A:
21.20
4mjwB-2hj9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		3 / 3 SER A 117
ARG A 139
HIS A 140
 None
 0.85A 4mjwA-2hj9A:
undetectable
4mjwB-2hj9A:
undetectable		 4mjwA-2hj9A:
21.20
4mjwB-2hj9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 6 GLY A 316
THR A 315
GLY A 177
ASN A  85
 None
 0.80A 5k4pA-2hj9A:
undetectable		 5k4pA-2hj9A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP
(Vibrio
harveyi) 		4 / 6 ASP A 112
ASP A 136
ASN A 159
GLN A  77
 None
None
AI2  A 501 (-3.3A)
AI2  A 501 (-2.8A)
 1.21A 5l6eA-2hj9A:
undetectable		 5l6eA-2hj9A:
20.76