SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hjg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.27A 1fkfA-2hjgA:
undetectable		 1fkfA-2hjgA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.29A 1fkjA-2hjgA:
undetectable		 1fkjA-2hjgA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 12 ASN A 119
LEU A 121
GLY A  92
THR A  18
ILE A  19
 GDP  A 800 (-3.3A)
None
None
GDP  A 800 (-3.5A)
None
 1.27A 1p93A-2hjgA:
undetectable		 1p93A-2hjgA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 10 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.24A 1q6iB-2hjgA:
undetectable		 1q6iB-2hjgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 7 PHE A 395
LEU A 352
GLY A 422
VAL A 362
 None
 0.89A 1t88A-2hjgA:
undetectable		 1t88A-2hjgA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.33A 1tcoC-2hjgA:
undetectable		 1tcoC-2hjgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.26A 1yatA-2hjgA:
undetectable		 1yatA-2hjgA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		3 / 3 PHE A 309
VAL A 293
TRP A 296
 None
 0.85A 2cc8A-2hjgA:
undetectable		 2cc8A-2hjgA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		3 / 3 PHE A 309
VAL A 293
TRP A 296
 None
 0.84A 2ccbA-2hjgA:
undetectable		 2ccbA-2hjgA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.28A 2fkeA-2hjgA:
undetectable		 2fkeA-2hjgA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 8 LEU A  55
ARG A  22
LEU A 152
GLY A  15
 None
None
None
GDP  A 800 (-3.1A)
 1.01A 2po5A-2hjgA:
4.8		 2po5A-2hjgA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		3 / 3 PHE A 309
VAL A 293
TRP A 296
 None
 0.83A 2vx9A-2hjgA:
undetectable		 2vx9A-2hjgA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 5 VAL A  85
VAL A   6
PHE A  88
ARG A  41
 None
 1.05A 3bjwB-2hjgA:
undetectable		 3bjwB-2hjgA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 9 ALA A 158
VAL A  85
ILE A  23
LEU A  55
ILE A  87
 None
 1.19A 3jw3B-2hjgA:
undetectable		 3jw3B-2hjgA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.35A 3o5rA-2hjgA:
undetectable		 3o5rA-2hjgA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 12 PRO A 341
ILE A 344
PHE A 218
TYR A 220
GLU A 198
 None
 1.48A 3q5pA-2hjgA:
undetectable		 3q5pA-2hjgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 PRO A 341
ILE A 344
PHE A 218
TYR A 220
GLU A 198
 None
 1.37A 3q5rA-2hjgA:
0.1		 3q5rA-2hjgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 5 GLN A 274
ASP A 275
ARG A 183
GLU A 244
 None
 1.31A 3r4xA-2hjgA:
undetectable		 3r4xA-2hjgA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 5 GLN A 274
ASP A 275
ARG A 183
GLU A 244
 None
 1.41A 3r55A-2hjgA:
0.0		 3r55A-2hjgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 10 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.33A 3uf8A-2hjgA:
undetectable		 3uf8A-2hjgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 12 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.34A 4drhA-2hjgA:
undetectable		 4drhA-2hjgA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.33A 4drjA-2hjgA:
undetectable		 4drjA-2hjgA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 10 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.36A 4laxA-2hjgA:
undetectable		 4laxA-2hjgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 10 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.26A 4qt3A-2hjgA:
undetectable		 4qt3A-2hjgA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 6 GLN A 274
ASP A 275
ARG A 183
GLU A 244
 None
 1.38A 4qyqC-2hjgA:
undetectable		 4qyqC-2hjgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		4 / 6 GLN A 274
ASP A 275
ARG A 183
GLU A 244
 None
 1.38A 5hpwC-2hjgA:
undetectable		 5hpwC-2hjgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 11 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.23A 5hw8B-2hjgA:
undetectable		 5hw8B-2hjgA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 8 ILE A 291
ALA A 323
VAL A 260
PHE A 178
VAL A 261
 None
 1.39A 5l94A-2hjgA:
undetectable		 5l94A-2hjgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 8 VAL A 263
ILE A 291
ALA A 323
VAL A 260
VAL A 261
 None
 1.24A 5l94A-2hjgA:
undetectable		 5l94A-2hjgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 12 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.29A 6mkeA-2hjgA:
undetectable
6mkeD-2hjgA:
undetectable		 6mkeA-2hjgA:
14.33
6mkeD-2hjgA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 12 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.28A 6mkeB-2hjgA:
undetectable
6mkeC-2hjgA:
undetectable		 6mkeB-2hjgA:
14.33
6mkeC-2hjgA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 2hjg GTP-BINDING PROTEIN
ENGA
(Bacillus
subtilis) 		5 / 10 TYR A 384
ASP A 132
VAL A 388
ILE A 130
PHE A 398
 None
 1.27A 6mkeC-2hjgA:
undetectable		 6mkeC-2hjgA:
14.33