SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hjr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		6 / 9 GLY A  21
ASP A  45
ILE A  46
TYR A  77
ALA A  90
ILE A 110
 APR  A3001 (-3.6A)
APR  A3001 (-3.1A)
APR  A3001 (-3.8A)
None
APR  A3001 (-3.6A)
APR  A3001 (-3.9A)
 1.02A 1cetA-2hjrA:
44.6		 1cetA-2hjrA:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 7 GLY A 231
ARG A 100
ILE A 233
VAL A 234
 None
CIT  A2001 (-3.9A)
None
None
 0.97A 1rxcC-2hjrA:
undetectable		 1rxcC-2hjrA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 ILE A  88
ALA A 247
ILE A  29
THR A 131
PHE A 141
 None
None
None
APR  A3001 (-2.5A)
None
 1.32A 1vq1A-2hjrA:
3.8		 1vq1A-2hjrA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 10 ALA A 250
ILE A  87
GLY A 154
HIS A 187
ASP A 135
 None
None
None
CIT  A2001 (-3.6A)
None
 1.38A 2b17A-2hjrA:
undetectable		 2b17A-2hjrA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 ALA A 254
LYS A  15
GLY A  34
LEU A  31
LEU A 258
 None
 1.32A 2nv4A-2hjrA:
undetectable		 2nv4A-2hjrA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A 112
TYR A 121
LEU A  80
VAL A  86
ILE A  88
 None
 1.18A 3g9eA-2hjrA:
undetectable		 3g9eA-2hjrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A 157
GLY A 283
ALA A 162
LEU A 134
THR A 226
 None
 1.05A 3mteB-2hjrA:
4.5		 3mteB-2hjrA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A 157
GLY A 283
ALA A 162
LEU A 134
THR A 226
 None
 1.06A 3p2kB-2hjrA:
5.1		 3p2kB-2hjrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 ASP A 135
GLY A 186
GLY A 188
GLY A 157
ASP A 160
 None
 0.99A 3uboA-2hjrA:
6.5		 3uboA-2hjrA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 GLY A 185
GLY A 186
LEU A 319
GLY A 157
ASP A 160
 None
 0.85A 4e3aB-2hjrA:
6.7		 4e3aB-2hjrA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 5 LEU A  58
ALA A  22
THR A  89
ILE A  87
 None
None
APR  A3001 (-4.9A)
None
 0.98A 4xe3A-2hjrA:
undetectable		 4xe3A-2hjrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 5 LEU A  58
ALA A  22
THR A  89
ILE A  87
 None
None
APR  A3001 (-4.9A)
None
 0.87A 4xe3B-2hjrA:
undetectable		 4xe3B-2hjrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 PRO A 285
ILE A 298
VAL A 277
THR A 269
 None
 1.14A 4xe5A-2hjrA:
3.7		 4xe5A-2hjrA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 GLY A 157
ASP A 160
GLY A 185
SER A 197
 None
 1.04A 4z53A-2hjrA:
undetectable
4z53B-2hjrA:
2.2		 4z53A-2hjrA:
18.83
4z53B-2hjrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 6 GLY A 157
ASP A 160
GLY A 283
SER A 197
 None
 1.02A 4z53A-2hjrA:
undetectable
4z53B-2hjrA:
2.2		 4z53A-2hjrA:
18.83
4z53B-2hjrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		5 / 12 SER A 113
SER A 145
ILE A 147
VAL A  86
VAL A 152
 APR  A3001 ( 4.8A)
None
None
None
None
 0.98A 5dpdA-2hjrA:
5.1		 5dpdA-2hjrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 ILE A 192
LYS A 306
PHE A 309
VAL A 184
 None
 1.08A 5dqyA-2hjrA:
undetectable		 5dqyA-2hjrA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		3 / 3 LYS A 142
LEU A 134
ILE A 128
 None
 0.81A 5kc4A-2hjrA:
0.6		 5kc4A-2hjrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 8 VAL A 299
PHE A 309
LEU A 301
VAL A 282
 None
 0.76A 5nujA-2hjrA:
undetectable		 5nujA-2hjrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2hjr MALATE DEHYDROGENASE
(Cryptosporidium
parvum) 		4 / 5 LYS A  36
GLN A 255
GLY A 154
ILE A  87
 None
 1.36A 6debB-2hjrA:
undetectable		 6debB-2hjrA:
17.49