SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hjs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 8 ALA A  83
LEU A 126
LEU A 125
LEU A 100
ALA A 105
 None
 1.29A 1e7cA-2hjsA:
undetectable		 1e7cA-2hjsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 319
LEU A 326
VAL A 325
LEU A  20
ALA A  19
 None
DIO  A 408 ( 4.8A)
None
None
None
 0.95A 1gseB-2hjsA:
2.5		 1gseB-2hjsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  11
GLY A  14
SER A  15
ALA A  19
LEU A  20
ASP A  58
 None
DIO  A 407 (-3.5A)
DIO  A 407 ( 3.0A)
None
None
None
 1.08A 1i9gA-2hjsA:
4.3		 1i9gA-2hjsA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 246
LEU A 309
ALA A 260
VAL A 248
LEU A 140
 None
 1.43A 1kt6A-2hjsA:
undetectable		 1kt6A-2hjsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 122
LEU A  69
LEU A 126
LEU A 330
 None
 0.79A 1mt1D-2hjsA:
undetectable
1mt1E-2hjsA:
undetectable		 1mt1D-2hjsA:
16.12
1mt1E-2hjsA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 243
SER A 159
VAL A 316
LEU A 287
 None
 1.22A 1yajB-2hjsA:
undetectable		 1yajB-2hjsA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  10
GLY A  11
THR A  13
ASP A  58
VAL A  56
 None
None
DIO  A 406 (-4.5A)
None
None
 1.08A 2a1nA-2hjsA:
undetectable		 2a1nA-2hjsA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 231
LEU A 152
LEU A 250
ILE A 216
VAL A 297
 None
 1.06A 2pnjA-2hjsA:
3.2		 2pnjA-2hjsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  11
GLY A  14
SER A  15
ALA A  19
LEU A  20
 None
DIO  A 407 (-3.5A)
DIO  A 407 ( 3.0A)
None
None
 0.80A 2yvlA-2hjsA:
3.0		 2yvlA-2hjsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  11
GLY A  14
ALA A  19
LEU A  20
VAL A  59
 None
DIO  A 407 (-3.5A)
None
None
None
 1.06A 2zulA-2hjsA:
4.2		 2zulA-2hjsA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 135
SER A 313
VAL A 201
CYH A 235
 None
 1.21A 3b9lA-2hjsA:
undetectable		 3b9lA-2hjsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  11
GLY A  14
ALA A  19
VAL A  59
VAL A  78
 None
DIO  A 407 (-3.5A)
None
None
None
 0.99A 3dmfA-2hjsA:
4.1		 3dmfA-2hjsA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  11
GLY A  14
ALA A  19
LEU A  20
VAL A  59
VAL A  78
 None
DIO  A 407 (-3.5A)
None
None
None
None
 1.10A 3dmhA-2hjsA:
4.2		 3dmhA-2hjsA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 228
LEU A 309
VAL A 307
VAL A 297
LEU A 265
 None
 1.02A 3gwxA-2hjsA:
undetectable		 3gwxA-2hjsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 8 SER A  42
THR A  13
ALA A  75
ALA A  74
 None
DIO  A 406 (-4.5A)
None
None
 0.90A 3ns1L-2hjsA:
undetectable		 3ns1L-2hjsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 4 SER A  42
GLY A 164
GLU A 170
 None
DIO  A 407 (-3.4A)
None
 0.66A 3raeA-2hjsA:
2.3
3raeC-2hjsA:
undetectable		 3raeA-2hjsA:
22.14
3raeC-2hjsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 248
VAL A 139
ALA A 134
LEU A 309
LEU A 154
 None
 0.97A 3sm2B-2hjsA:
undetectable		 3sm2B-2hjsA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  94
LEU A 331
ALA A 105
LEU A 117
GLY A  98
 None
 1.00A 3vaqB-2hjsA:
4.6		 3vaqB-2hjsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 10 PHE A  49
ARG A  46
LEU A  54
GLY A  48
ALA A  86
 None
 1.44A 4fe1A-2hjsA:
undetectable
4fe1J-2hjsA:
undetectable		 4fe1A-2hjsA:
18.99
4fe1J-2hjsA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 327
SER A 128
VAL A 112
LEU A 223
LEU A 330
 None
 1.23A 4or0B-2hjsA:
undetectable		 4or0B-2hjsA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 12 CYH A  91
VAL A  10
LEU A  96
LEU A 125
ALA A  89
 None
 1.28A 4rtbA-2hjsA:
undetectable		 4rtbA-2hjsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 257
VAL A 264
LEU A 143
 DIO  A 402 ( 4.0A)
None
None
 0.67A 5e5jB-2hjsA:
undetectable		 5e5jB-2hjsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 260
THR A 262
VAL A 264
VAL A 307
 None
 1.03A 5eckA-2hjsA:
undetectable		 5eckA-2hjsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 260
THR A 262
VAL A 264
VAL A 307
 None
 1.00A 5eckD-2hjsA:
undetectable		 5eckD-2hjsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  11
GLY A  14
SER A  15
ASP A  58
 None
DIO  A 407 (-3.5A)
DIO  A 407 ( 3.0A)
None
 0.65A 5ergB-2hjsA:
undetectable		 5ergB-2hjsA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 332
GLY A 328
LEU A  69
LEU A  24
LEU A  20
 None
 1.23A 5fhzC-2hjsA:
4.3		 5fhzC-2hjsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 163
GLY A 164
SER A 161
SER A 159
 None
DIO  A 407 (-3.4A)
None
None
 1.26A 5uunB-2hjsA:
undetectable		 5uunB-2hjsA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 2hjs USG-1 PROTEIN
HOMOLOG
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 335
HIS A 334
LEU A 327
VAL A 110
 None
 1.30A 6g2pA-2hjsA:
5.0		 6g2pA-2hjsA:
20.86