SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DJR_F_BEZF1305_0
(HEAT-LABILE
ENTEROTOXIN)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 4 TYR A 140
ARG A 136
ASN A 104
TRP A 107
 None
 1.41A 1djrF-2hk7A:
0.1		 1djrF-2hk7A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.94A 1hsgA-2hk7A:
undetectable		 1hsgA-2hk7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
ALA A 147
VAL A 183
VAL A 128
ILE A 126
 None
 0.99A 1hsgB-2hk7A:
undetectable		 1hsgB-2hk7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.74A 1hsgB-2hk7A:
undetectable		 1hsgB-2hk7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.99A 2avoB-2hk7A:
undetectable		 2avoB-2hk7A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.02A 2avvB-2hk7A:
undetectable		 2avvB-2hk7A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.92A 2bpxB-2hk7A:
undetectable		 2bpxB-2hk7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.99A 2o4kB-2hk7A:
undetectable		 2o4kB-2hk7A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.00A 2o4lB-2hk7A:
undetectable		 2o4lB-2hk7A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 ILE A 215
PRO A 174
GLY A 130
TRP A 152
 None
 1.11A 2pnjB-2hk7A:
5.6		 2pnjB-2hk7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.06A 2q63A-2hk7A:
undetectable		 2q63A-2hk7A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.00A 2q64B-2hk7A:
undetectable		 2q64B-2hk7A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.00A 2r5pB-2hk7A:
undetectable		 2r5pB-2hk7A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.12A 3bvbA-2hk7A:
undetectable		 3bvbA-2hk7A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
ALA A 147
ILE A 118
VAL A 128
ILE A 126
 None
 0.96A 3d1xB-2hk7A:
undetectable		 3d1xB-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 11 ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.94A 3ekxB-2hk7A:
undetectable		 3ekxB-2hk7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.99A 3el1B-2hk7A:
undetectable		 3el1B-2hk7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 VAL A 138
TYR A 257
SER A 113
LEU A 114
LEU A 233
 None
 0.96A 3hs6A-2hk7A:
undetectable		 3hs6A-2hk7A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.08A 3jw2B-2hk7A:
undetectable		 3jw2B-2hk7A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.99A 3k4vB-2hk7A:
undetectable		 3k4vB-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 8 PRO A  15
SER A 189
LEU A 192
ASP A 196
 None
 0.86A 3lsfH-2hk7A:
undetectable		 3lsfH-2hk7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
ALA A 147
ILE A 118
VAL A 128
ILE A 126
 None
 0.97A 3nduB-2hk7A:
undetectable		 3nduB-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
ALA A 147
ILE A 118
VAL A 128
ILE A 126
 None
 0.96A 3ndxA-2hk7A:
undetectable		 3ndxA-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.09A 3nu5A-2hk7A:
undetectable		 3nu5A-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.98A 3oxcA-2hk7A:
undetectable		 3oxcA-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
ALA A 147
ILE A 118
VAL A 128
ILE A 126
 None
 1.02A 3oxcB-2hk7A:
undetectable		 3oxcB-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
ALA A 147
ILE A 118
VAL A 128
ILE A 126
 None
 1.01A 3tkgC-2hk7A:
undetectable		 3tkgC-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.00A 3tkgD-2hk7A:
undetectable		 3tkgD-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 12 GLY A 146
ALA A 147
ILE A 118
VAL A 128
ILE A 126
 None
 0.97A 3tkgD-2hk7A:
undetectable		 3tkgD-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.03A 3tkwB-2hk7A:
undetectable		 3tkwB-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.03A 3tl9B-2hk7A:
undetectable		 3tl9B-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 0.98A 4jecA-2hk7A:
undetectable		 4jecA-2hk7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 PHE A  55
THR A  66
PHE A  69
ILE A  63
 None
 1.02A 4jx1E-2hk7A:
undetectable		 4jx1E-2hk7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 5 ASN A  64
GLY A 243
ASP A  82
ASP A 106
 None
 1.14A 4n48B-2hk7A:
4.0		 4n48B-2hk7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 4 ASN A  64
GLY A 243
ASP A  82
ASP A 106
 None
 1.23A 4n49A-2hk7A:
4.2		 4n49A-2hk7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 7 ILE A 118
PHE A 110
LEU A 111
ILE A 126
 None
 0.79A 4rmjA-2hk7A:
6.4		 4rmjA-2hk7A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 ASP A 213
LEU A 192
GLY A 191
 None
 0.38A 4xmfA-2hk7A:
undetectable		 4xmfA-2hk7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		4 / 6 ARG A 268
LEU A 240
TYR A 257
SER A 113
 None
 0.95A 5phhA-2hk7A:
undetectable		 5phhA-2hk7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		3 / 3 ASN A 201
VAL A 181
HIS A 209
 None
 0.79A 6a5yD-2hk7A:
undetectable		 6a5yD-2hk7A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		6 / 12 GLY A 146
ALA A 147
VAL A 183
ILE A 118
VAL A 128
ILE A 126
 None
 1.06A 6dilB-2hk7A:
undetectable		 6dilB-2hk7A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 PHE A  55
LEU A  58
GLY A  62
ILE A  63
PHE A  95
 None
 1.17A 6ebpB-2hk7A:
undetectable		 6ebpB-2hk7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2hk7 SHIKIMATE
DEHYDROGENASE
(Aquifex
aeolicus) 		5 / 10 PHE A  55
LEU A  58
GLY A  62
ILE A  63
PHE A  95
 None
 1.16A 6ebpC-2hk7A:
undetectable		 6ebpC-2hk7A:
13.01