SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A 270
ARG A 274
TYR A 290
GLN A 252
 None
SO4  A 382 (-3.8A)
None
None
 1.23A 1nx9A-2hkeA:
undetectable		 1nx9A-2hkeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A 270
ARG A 274
TYR A 290
GLN A 252
 None
SO4  A 382 (-3.8A)
None
None
 1.20A 1nx9B-2hkeA:
undetectable		 1nx9B-2hkeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A 270
ARG A 274
TYR A 290
GLN A 252
 None
SO4  A 382 (-3.8A)
None
None
 1.22A 1nx9C-2hkeA:
undetectable		 1nx9C-2hkeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 TYR A 270
ARG A 274
TYR A 290
GLN A 252
 None
SO4  A 382 (-3.8A)
None
None
 1.21A 1nx9D-2hkeA:
undetectable		 1nx9D-2hkeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 VAL A  52
ALA A 129
LEU A  85
PHE A 130
 None
 0.95A 1q97B-2hkeA:
undetectable		 1q97B-2hkeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 PHE A 299
PHE A 301
SER A  38
ARG A 149
 None
 1.00A 1rqpB-2hkeA:
undetectable		 1rqpB-2hkeA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 PHE A 299
PHE A 301
SER A  38
ARG A 149
 None
 1.00A 1rqpC-2hkeA:
undetectable		 1rqpC-2hkeA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 PHE A 299
PHE A 301
SER A  38
ARG A 149
 None
 1.00A 1rqpA-2hkeA:
undetectable		 1rqpA-2hkeA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 11 MET A 245
LEU A 359
VAL A 311
MET A 313
MET A 272
 None
 1.24A 2n27A-2hkeA:
0.0		 2n27A-2hkeA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 PHE A 299
PHE A 301
SER A  38
ARG A 149
 None
 1.01A 2v7uA-2hkeA:
undetectable		 2v7uA-2hkeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 PHE A 299
PHE A 301
SER A  38
ARG A 149
 None
 1.01A 2v7uB-2hkeA:
undetectable		 2v7uB-2hkeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASN A  13
ASP A 293
ARG A  23
 None
 0.75A 3k13C-2hkeA:
undetectable		 3k13C-2hkeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 ILE A 262
THR A 258
THR A 257
SER A 210
 None
 1.16A 3snfA-2hkeA:
undetectable		 3snfA-2hkeA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 SER A 198
SER A 199
MET A 203
GLY A 295
 None
None
SO4  A 381 ( 4.8A)
None
 1.03A 4af0A-2hkeA:
undetectable		 4af0A-2hkeA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 LEU A 303
ALA A 289
VAL A 185
ILE A  17
 None
 0.97A 4eyrA-2hkeA:
undetectable		 4eyrA-2hkeA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 ALA A 294
SER A 199
ALA A 113
SER A 115
SER A 146
 None
 1.32A 4twdA-2hkeA:
undetectable
4twdB-2hkeA:
undetectable
4twdC-2hkeA:
undetectable
4twdD-2hkeA:
undetectable
4twdE-2hkeA:
undetectable		 4twdA-2hkeA:
20.82
4twdB-2hkeA:
20.82
4twdC-2hkeA:
20.82
4twdD-2hkeA:
20.82
4twdE-2hkeA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 VAL A 185
PHE A  16
ARG A 149
 None
 0.88A 4xr4B-2hkeA:
undetectable		 4xr4B-2hkeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A 310
LEU A 348
ILE A 349
ARG A 274
PHE A 318
 None
None
SO4  A 382 (-4.0A)
SO4  A 382 (-3.8A)
None
 1.46A 5vlmE-2hkeA:
undetectable		 5vlmE-2hkeA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ASP A 329
SER A  44
SER A  42
 None
SO4  A 383 ( 4.8A)
SO4  A 383 (-2.5A)
 0.80A 6mxtA-2hkeA:
undetectable		 6mxtA-2hkeA:
21.70