SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 ILE A 159
LEU A  97
LEU A 199
LEU A 148
ILE A 145
 None
EDO  A 302 (-4.8A)
None
None
None
 1.07A 1g5yB-2hkuA:
2.8		 1g5yB-2hkuA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 ALA A 143
LEU A  97
PHE A 166
ASN A 198
ARG A 156
 EDO  A 302 (-3.3A)
EDO  A 302 (-4.8A)
EDO  A 302 ( 4.5A)
None
None
 1.13A 1u72A-2hkuA:
undetectable		 1u72A-2hkuA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 8 GLY A  99
LEU A 101
LEU A 102
ILE A 170
 None
 0.83A 3nbqC-2hkuA:
undetectable		 3nbqC-2hkuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 8 SER A  60
LEU A 125
LEU A 128
MET A 118
 None
 0.87A 4oj4A-2hkuA:
undetectable		 4oj4A-2hkuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		5 / 12 GLY A  91
VAL A  98
LEU A 144
ASN A 198
PHE A 196
 None
None
EDO  A 302 (-4.1A)
None
EDO  A 304 (-4.4A)
 1.11A 4pd5A-2hkuA:
undetectable		 4pd5A-2hkuA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 8 SER A  60
LEU A 125
LEU A 128
MET A 118
 None
 0.85A 4xtaB-2hkuA:
undetectable		 4xtaB-2hkuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Rhodococcus
jostii) 		4 / 6 PHE A 112
VAL A  73
ALA A  69
THR A  28
 None
 0.94A 5t7bA-2hkuA:
undetectable		 5t7bA-2hkuA:
13.25