SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hkv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 2hkv HYPOTHETICAL PROTEIN
(Exiguobacterium
sibiricum) 		4 / 4 LEU A  53
GLY A  13
ASP A   9
TYR A  92
 None
 1.42A 1oxrA-2hkvA:
2.5		 1oxrA-2hkvA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 2hkv HYPOTHETICAL PROTEIN
(Exiguobacterium
sibiricum) 		4 / 5 LEU A  49
TRP A  31
LEU A  22
GLN A 130
 None
None
None
CL  A 150 (-3.8A)
 0.90A 1p93D-2hkvA:
undetectable		 1p93D-2hkvA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2hkv HYPOTHETICAL PROTEIN
(Exiguobacterium
sibiricum) 		3 / 3 HIS A 127
HIS A 123
HIS A 126
 NI  A 149 ( 3.2A)
NI  A 149 ( 3.3A)
None
 0.71A 1w2zA-2hkvA:
undetectable		 1w2zA-2hkvA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 2hkv HYPOTHETICAL PROTEIN
(Exiguobacterium
sibiricum) 		3 / 3 HIS A 127
HIS A 123
HIS A 126
 NI  A 149 ( 3.2A)
NI  A 149 ( 3.3A)
None
 0.71A 2w0qB-2hkvA:
undetectable		 2w0qB-2hkvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 2hkv HYPOTHETICAL PROTEIN
(Exiguobacterium
sibiricum) 		5 / 12 HIS A  48
GLU A  54
ASP A  86
LEU A  85
VAL A  16
 NI  A 149 (-3.2A)
None
None
None
None
 1.07A 4fqsA-2hkvA:
undetectable		 4fqsA-2hkvA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 2hkv HYPOTHETICAL PROTEIN
(Exiguobacterium
sibiricum) 		5 / 12 HIS A  48
GLU A  54
ASP A  86
LEU A  85
VAL A  16
 NI  A 149 (-3.2A)
None
None
None
None
 1.08A 4fqsB-2hkvA:
undetectable		 4fqsB-2hkvA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hkv HYPOTHETICAL PROTEIN
(Exiguobacterium
sibiricum) 		4 / 8 LEU A 132
VAL A  45
LEU A  49
GLY A  15
 None
 0.86A 4r3aA-2hkvA:
undetectable		 4r3aA-2hkvA:
19.48