SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hl9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2hl9 UBIQUITIN-LIKE-SPECI
FIC PROTEASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 615
ALA A 619
PHE A 610
LEU A 449
THR A 617
 None
 1.18A 1dhfA-2hl9A:
undetectable		 1dhfA-2hl9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2hl9 UBIQUITIN-LIKE-SPECI
FIC PROTEASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 531
PRO A 507
GLY A 581
LEU A 449
LEU A 510
 None
None
OCS  A 580 ( 2.4A)
None
None
 1.34A 2nv4A-2hl9A:
undetectable		 2nv4A-2hl9A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2hl9 UBIQUITIN-LIKE-SPECI
FIC PROTEASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 603
ALA A 604
ASP A 600
TYR A 583
 None
 1.19A 3rodD-2hl9A:
undetectable		 3rodD-2hl9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 2hl9 UBIQUITIN-LIKE-SPECI
FIC PROTEASE 1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 527
ILE A 504
GLU A 554
LEU A 479
 None
 0.81A 3ua5B-2hl9A:
undetectable		 3ua5B-2hl9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2hl9 UBIQUITIN-LIKE-SPECI
FIC PROTEASE 1
(Saccharomyces
cerevisiae) 		5 / 11 SER A 592
THR A 588
ALA A 619
GLU A 455
THR A 468
 None
 1.25A 4zjoD-2hl9A:
undetectable		 4zjoD-2hl9A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2hl9 UBIQUITIN-LIKE-SPECI
FIC PROTEASE 1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 551
GLY A 561
ILE A 560
ASP A 521
 None
 0.81A 6ag0A-2hl9A:
undetectable		 6ag0A-2hl9A:
13.46