SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2hle EPHRIN-B2
(Homo
sapiens) 		4 / 7 VAL B 167
LYS B 133
TYR B 135
GLU B 128
 None
 1.22A 3hs4A-2hleB:
undetectable		 3hs4A-2hleB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hle EPHRIN-B2
(Homo
sapiens) 		4 / 8 ILE B  31
LEU B  33
VAL B 167
GLY B 168
 None
 0.78A 3w1wA-2hleB:
undetectable		 3w1wA-2hleB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2hle EPHRIN-B2
(Homo
sapiens) 		3 / 3 LEU B  33
ASP B  62
ILE B  57
 None
 0.70A 4xi3D-2hleB:
undetectable		 4xi3D-2hleB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 2hle EPHRIN-B2
(Homo
sapiens) 		5 / 12 GLY B 147
GLY B 153
GLU B 152
ASP B  90
ILE B 138
 None
 1.02A 5njvD-2hleB:
undetectable		 5njvD-2hleB:
19.23