SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hlj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 0.97A 1qzfA-2hljA:
undetectable		 1qzfA-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 0.97A 1qzfB-2hljA:
undetectable		 1qzfB-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 0.97A 1qzfC-2hljA:
undetectable		 1qzfC-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 0.97A 1qzfD-2hljA:
undetectable		 1qzfD-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 0.99A 1qzfE-2hljA:
undetectable		 1qzfE-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		4 / 6 LEU A  82
GLY A  83
ALA A 144
PRO A 145
 None
 0.47A 3huoA-2hljA:
undetectable		 3huoA-2hljA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		4 / 6 ASP A  40
GLY A  53
ASP A  36
THR A  35
 None
GOL  A 157 (-4.2A)
GOL  A 157 (-3.7A)
GOL  A 157 (-3.8A)
 1.10A 3vqrA-2hljA:
undetectable		 3vqrA-2hljA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		4 / 5 ASP A  40
GLY A  53
ASP A  36
THR A  35
 None
GOL  A 157 (-4.2A)
GOL  A 157 (-3.7A)
GOL  A 157 (-3.8A)
 1.13A 3vqrB-2hljA:
undetectable		 3vqrB-2hljA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 1.12A 4ky8A-2hljA:
undetectable		 4ky8A-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 1.11A 4ky8D-2hljA:
undetectable		 4ky8D-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 1.10A 4ky8E-2hljA:
undetectable		 4ky8E-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 1.11A 4q0dA-2hljA:
undetectable		 4q0dA-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 1.11A 4q0dB-2hljA:
undetectable		 4q0dB-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 VAL A  77
LEU A  22
SER A  32
ILE A  63
THR A   9
 None
None
GOL  A 157 (-2.8A)
None
None
 1.11A 4q0dE-2hljA:
undetectable		 4q0dE-2hljA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2hlj HYPOTHETICAL PROTEIN
(Pseudomonas
putida) 		5 / 12 GLU A 102
VAL A 103
ALA A 106
SER A  94
PRO A 145
 None
 1.21A 5syeB-2hljA:
undetectable		 5syeB-2hljA:
16.78