SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 6 GLU A 178
THR A  89
ALA A  91
LEU A  93
 None
 0.94A 1etb2-2hlsA:
undetectable		 1etb2-2hlsA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 PHE A 208
TYR A 213
PRO A 212
 None
 0.98A 1mcnA-2hlsA:
undetectable
1mcnB-2hlsA:
undetectable
1mcnP-2hlsA:
undetectable		 1mcnA-2hlsA:
21.72
1mcnB-2hlsA:
21.72
1mcnP-2hlsA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 GLU A 178
THR A  89
ALA A  91
LEU A  93
 None
 0.93A 1sn5C-2hlsA:
undetectable		 1sn5C-2hlsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 GLU A  40
GLU A 181
LEU A  48
 None
 0.72A 1v8bA-2hlsA:
undetectable		 1v8bA-2hlsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 GLU A  40
GLU A 181
LEU A  48
 None
 0.70A 1v8bB-2hlsA:
undetectable		 1v8bB-2hlsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 GLU A 126
GLU A 122
LEU A 158
 None
 0.74A 1v8bB-2hlsA:
undetectable		 1v8bB-2hlsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 11 GLU A 107
ALA A 104
PRO A 154
ASP A   8
ASP A  44
 None
 1.31A 2admA-2hlsA:
undetectable		 2admA-2hlsA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 VAL A 209
VAL A 207
ASP A 187
 None
 0.77A 2fumD-2hlsA:
undetectable		 2fumD-2hlsA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 10 HIS A 161
VAL A 114
LEU A 176
LEU A  93
GLY A  95
 None
 1.04A 2xf3A-2hlsA:
undetectable		 2xf3A-2hlsA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 6 THR A 129
LEU A 218
VAL A 221
VAL A 174
 None
 0.98A 2z97A-2hlsA:
undetectable		 2z97A-2hlsA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 ASP A  44
THR A  45
HIS A 161
LEU A   9
 None
 1.00A 3abmA-2hlsA:
undetectable
3abmC-2hlsA:
undetectable
3abmP-2hlsA:
undetectable		 3abmA-2hlsA:
18.71
3abmC-2hlsA:
21.68
3abmP-2hlsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 ILE A 202
PHE A 217
LEU A 218
ILE A 175
LEU A 133
 None
 0.95A 3k2hB-2hlsA:
undetectable		 3k2hB-2hlsA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 GLU A 178
GLU A 184
ASN A 185
 None
 0.76A 3lp9B-2hlsA:
undetectable
3lp9D-2hlsA:
undetectable		 3lp9B-2hlsA:
19.14
3lp9D-2hlsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 7 VAL A 114
PHE A  92
PHE A  52
ILE A 108
 None
 0.97A 3zjqA-2hlsA:
undetectable		 3zjqA-2hlsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 7 VAL A 114
PHE A  92
PHE A  52
ILE A 108
 None
 0.95A 3zjqB-2hlsA:
undetectable		 3zjqB-2hlsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 GLU A 178
THR A  89
ALA A  91
LEU A  93
 None
 0.92A 4iizB-2hlsA:
undetectable		 4iizB-2hlsA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 GLU A 178
THR A  89
ALA A  91
LEU A  93
 None
 0.95A 4ik6B-2hlsA:
undetectable		 4ik6B-2hlsA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 ILE A 102
ILE A 108
GLU A 184
PRO A 148
 None
 0.84A 4jltA-2hlsA:
undetectable		 4jltA-2hlsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 ASP A  44
THR A  45
HIS A 161
LEU A   9
 None
 1.05A 5b1aA-2hlsA:
undetectable
5b1aC-2hlsA:
undetectable
5b1aP-2hlsA:
undetectable		 5b1aA-2hlsA:
18.71
5b1aC-2hlsA:
21.68
5b1aP-2hlsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 ASP A  44
THR A  45
HIS A 161
LEU A   9
 None
 1.16A 5b1bA-2hlsA:
undetectable
5b1bC-2hlsA:
undetectable
5b1bP-2hlsA:
undetectable		 5b1bA-2hlsA:
18.71
5b1bC-2hlsA:
21.68
5b1bP-2hlsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 12 ILE A 142
VAL A 194
GLY A 193
TYR A 220
LEU A 159
 None
 1.18A 5ienA-2hlsA:
undetectable		 5ienA-2hlsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 8 ASP A  44
THR A  45
HIS A 161
LEU A   9
 None
 1.04A 5wauA-2hlsA:
undetectable
5wauC-2hlsA:
undetectable
5wauc-2hlsA:
undetectable		 5wauA-2hlsA:
18.71
5wauC-2hlsA:
21.68
5wauc-2hlsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		4 / 7 LEU A   9
ASP A  44
THR A  45
HIS A 161
 None
 1.04A 5wauC-2hlsA:
undetectable
5waua-2hlsA:
undetectable
5wauc-2hlsA:
undetectable		 5wauC-2hlsA:
21.68
5waua-2hlsA:
18.71
5wauc-2hlsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 GLU A 126
LEU A 125
ARG A 117
 None
 0.73A 6d8fA-2hlsA:
undetectable		 6d8fA-2hlsA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		3 / 3 HIS A  31
ASN A  68
LEU A  67
 None
 0.69A 6f7lB-2hlsA:
undetectable		 6f7lB-2hlsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2hls PROTEIN DISULFIDE
OXIDOREDUCTASE
(Aeropyrum
pernix) 		5 / 11 VAL A  90
PHE A  92
VAL A  97
ILE A 115
LEU A 111
 None
 1.13A 6h1lB-2hlsA:
undetectable		 6h1lB-2hlsA:
20.88