SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hlw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		4 / 8 LEU A  90
VAL A 116
GLY A 121
LEU A 147
 None
 0.95A 1jlbA-2hlwA:
undetectable		 1jlbA-2hlwA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		3 / 3 GLU A 146
LYS A 133
VAL A 130
 None
 0.93A 1l2iA-2hlwA:
undetectable		 1l2iA-2hlwA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 10 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.39A 1lw0A-2hlwA:
undetectable		 1lw0A-2hlwA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 11 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.36A 1lwcA-2hlwA:
undetectable		 1lwcA-2hlwA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 10 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.33A 2hndA-2hlwA:
undetectable		 2hndA-2hlwA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 10 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.34A 2hnyA-2hlwA:
undetectable		 2hnyA-2hlwA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 9 LEU A  90
VAL A 123
TYR A  88
GLY A 121
LEU A 147
 None
 1.43A 3lp0A-2hlwA:
undetectable		 3lp0A-2hlwA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 10 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.32A 3lp1A-2hlwA:
undetectable		 3lp1A-2hlwA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 10 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.30A 3qipA-2hlwA:
undetectable		 3qipA-2hlwA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 9 LEU A  90
LYS A  91
VAL A 116
GLY A 121
LEU A 147
 None
 1.22A 4b3oA-2hlwA:
undetectable		 4b3oA-2hlwA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 9 LEU A  90
VAL A 123
TYR A  88
GLY A 121
LEU A 147
 None
 1.44A 4b3oA-2hlwA:
undetectable		 4b3oA-2hlwA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		3 / 3 GLU A 146
ARG A 149
GLN A 135
 None
 0.86A 4rtbA-2hlwA:
undetectable		 4rtbA-2hlwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		5 / 11 LEU A  90
VAL A 116
TYR A  88
GLY A 121
LEU A 147
 None
 1.29A 5hbmA-2hlwA:
undetectable		 5hbmA-2hlwA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens) 		4 / 7 ASN A 114
GLY A 121
VAL A 143
LEU A 147
 None
 0.84A 6dwnB-2hlwA:
undetectable		 6dwnB-2hlwA:
17.65