SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 ALA A 102
ASP A  99
ILE A   7
LEU A  45
ILE A  15
 None
 1.07A 1d1gB-2hlyA:
undetectable		 1d1gB-2hlyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 ALA A 102
ASP A  99
PHE A 100
ILE A   7
LEU A  45
 None
 1.28A 1dreA-2hlyA:
undetectable		 1dreA-2hlyA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		3 / 3 ALA A 169
VAL A 167
TRP A 171
 None
 1.01A 1gmkA-2hlyA:
undetectable
1gmkB-2hlyA:
undetectable		 1gmkA-2hlyA:
7.87
1gmkB-2hlyA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 TYR A  12
PHE A 105
LEU A  64
HIS A  88
TYR A  62
 None
 1.39A 1mmkA-2hlyA:
undetectable		 1mmkA-2hlyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 ALA A 102
ASP A  99
ILE A   7
LEU A  45
ILE A  15
 None
 1.02A 1rb3B-2hlyA:
undetectable		 1rb3B-2hlyA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		3 / 3 LEU A  45
LEU A 123
PHE A 100
 None
 0.56A 2pgrA-2hlyA:
undetectable		 2pgrA-2hlyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 ALA A 102
ASP A  99
ILE A   7
LEU A  45
ILE A  15
 None
 1.01A 3tq9A-2hlyA:
undetectable		 3tq9A-2hlyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 ALA A 102
ASP A  99
ILE A   7
LEU A  45
ILE A  15
 None
 1.08A 4dfrB-2hlyA:
undetectable		 4dfrB-2hlyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 ALA A 102
PHE A 100
ILE A   7
LEU A  45
ILE A  15
 None
 1.10A 4pstA-2hlyA:
undetectable		 4pstA-2hlyA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		3 / 3 ARG A  14
LYS A   8
TYR A  49
 None
 1.09A 6gnaA-2hlyA:
undetectable		 6gnaA-2hlyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		3 / 3 ARG A  14
LYS A   8
TYR A  49
 None
 1.09A 6gnbA-2hlyA:
undetectable		 6gnbA-2hlyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2hly HYPOTHETICAL PROTEIN
ATU2299
(Agrobacterium
fabrum) 		5 / 12 ALA A 102
PHE A 100
ILE A   7
LEU A  45
ILE A  15
 None
 1.06A 7dfrA-2hlyA:
undetectable		 7dfrA-2hlyA:
18.78