SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 ALA A  23
ILE A  68
GLY A  15
THR A 190
SER A  19
 None
None
None
None
MG  A 374 ( 3.1A)
 1.15A 1c9sN-2hmaA:
undetectable
1c9sO-2hmaA:
undetectable		 1c9sN-2hmaA:
11.38
1c9sO-2hmaA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 GLY A  15
THR A 190
SER A  19
ALA A  23
ILE A  68
 None
None
MG  A 374 ( 3.1A)
None
None
 1.17A 1c9sL-2hmaA:
undetectable
1c9sV-2hmaA:
undetectable		 1c9sL-2hmaA:
11.38
1c9sV-2hmaA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 THR A 153
GLY A 356
LYS A 310
TYR A 349
 None
 1.05A 1gtiC-2hmaA:
undetectable		 1gtiC-2hmaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 THR A 329
LEU A 359
ASP A 361
GLU A  90
 None
 1.07A 1mxgA-2hmaA:
undetectable		 1mxgA-2hmaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A 358
GLN A 292
VAL A 101
ALA A 345
 None
 0.93A 1p6kA-2hmaA:
undetectable		 1p6kA-2hmaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 HIS A 280
GLY A 275
GLY A 227
TYR A 273
VAL A 274
 None
 1.14A 1pg2A-2hmaA:
undetectable		 1pg2A-2hmaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  41
PHE A  84
TRP A  80
 None
 1.29A 1r15C-2hmaA:
undetectable		 1r15C-2hmaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  41
PHE A  84
TRP A  80
 None
 1.28A 1r15F-2hmaA:
undetectable		 1r15F-2hmaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  41
PHE A  84
TRP A  80
 None
 1.29A 1r15G-2hmaA:
undetectable		 1r15G-2hmaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  41
PHE A  84
TRP A  80
 None
 1.28A 1r15H-2hmaA:
undetectable		 1r15H-2hmaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 SER A 285
THR A 341
PRO A 342
GLY A 242
 None
 0.98A 2ddwB-2hmaA:
undetectable		 2ddwB-2hmaA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		11 / 11 GLY A  12
SER A  14
SER A  19
ASP A 100
ASN A 104
LYS A 108
THR A 126
GLY A 127
HIS A 128
GLN A 152
PHE A 155
 SAM  A 375 (-3.3A)
MG  A 374 ( 2.8A)
MG  A 374 ( 3.1A)
SAM  A 375 (-3.8A)
SAM  A 375 (-2.8A)
SAM  A 375 (-2.8A)
SAM  A 375 (-4.2A)
SAM  A 375 (-3.2A)
SAM  A 375 (-3.5A)
SAM  A 375 (-4.0A)
SAM  A 375 (-3.6A)
 0.00A 2hmaA-2hmaA:
61.5		 2hmaA-2hmaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 171
LEU A 143
MET A 142
 None
 0.63A 2itzA-2hmaA:
undetectable		 2itzA-2hmaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 PHE A 201
PHE A 210
PHE A 207
 None
 0.77A 2od9A-2hmaA:
undetectable		 2od9A-2hmaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 MET A 142
LEU A 164
VAL A 347
GLY A 357
 None
 0.89A 2po5B-2hmaA:
undetectable		 2po5B-2hmaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 MET A 142
LEU A 164
VAL A 347
GLY A 357
 None
 0.91A 2qd5A-2hmaA:
undetectable		 2qd5A-2hmaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 MET A 142
LEU A 164
VAL A 347
GLY A 357
 None
 0.85A 2qd5B-2hmaA:
2.2		 2qd5B-2hmaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 PHE A 201
PHE A 210
PHE A 207
 None
 0.77A 2qqgA-2hmaA:
undetectable		 2qqgA-2hmaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 ARG A 297
PHE A 295
MET A 299
PHE A 303
 None
 0.98A 3af3A-2hmaA:
undetectable		 3af3A-2hmaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 359
ALA A 290
THR A 329
VAL A 331
 None
 0.93A 3d2tA-2hmaA:
undetectable		 3d2tA-2hmaA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A  42
ASP A  43
ASP A  81
TYR A 214
 None
 1.15A 3havA-2hmaA:
undetectable		 3havA-2hmaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 SER A  20
GLY A  16
SER A 189
 None
MG  A 374 (-3.5A)
None
 0.63A 3loqA-2hmaA:
3.8		 3loqA-2hmaA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 114
ARG A  82
LYS A 110
 None
 1.17A 3wipG-2hmaA:
undetectable		 3wipG-2hmaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 359
ALA A 290
THR A 329
VAL A 331
 None
 0.88A 4ik7A-2hmaA:
undetectable		 4ik7A-2hmaA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A 264
VAL A 262
GLN A 243
PRO A 342
ILE A 373
 None
 1.47A 4j4vD-2hmaA:
0.0
4j4vE-2hmaA:
0.0		 4j4vD-2hmaA:
21.19
4j4vE-2hmaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A  82
LYS A 105
LYS A 110
 None
 1.38A 4k50E-2hmaA:
undetectable		 4k50E-2hmaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A   2
ARG A   8
VAL A  33
 None
 1.00A 4x3uA-2hmaA:
undetectable
4x3uB-2hmaA:
undetectable		 4x3uA-2hmaA:
10.11
4x3uB-2hmaA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 109
ALA A 130
GLY A 172
TYR A 129
 None
 1.01A 5uxdA-2hmaA:
undetectable		 5uxdA-2hmaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A  35
SER A  20
THR A  22
VAL A  11
 None
 1.17A 5ysiA-2hmaA:
undetectable		 5ysiA-2hmaA:
16.67