SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		5 / 11 TYR A 276
LEU A  67
ARG A  66
LEU A  13
ALA A  27
 None
 1.50A 1hk1A-2hmcA:
0.7		 1hk1A-2hmcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		4 / 7 LEU A 125
ILE A 124
PHE A 121
ALA A 133
 None
 0.99A 1oniB-2hmcA:
undetectable
1oniC-2hmcA:
undetectable		 1oniB-2hmcA:
16.91
1oniC-2hmcA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		3 / 3 TRP A 308
VAL A 201
ARG A 173
 None
 0.95A 3b0wA-2hmcA:
undetectable		 3b0wA-2hmcA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		3 / 3 ASN A 281
HIS A 279
VAL A 261
 None
 0.71A 3elzB-2hmcA:
undetectable		 3elzB-2hmcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  77
GLY A  47
ALA A  90
HIS A 120
ILE A 124
 None
None
None
MG  A 502 (-4.6A)
None
 0.89A 3fuuA-2hmcA:
undetectable		 3fuuA-2hmcA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		5 / 12 THR A 187
THR A 180
ILE A   5
ILE A  75
TYR A  -3
 None
 1.14A 3gwxA-2hmcA:
undetectable		 3gwxA-2hmcA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		4 / 5 LEU A 223
GLN A 246
LEU A 248
GLU A 245
 None
 1.06A 3h5gA-2hmcA:
undetectable
3h5gB-2hmcA:
undetectable		 3h5gA-2hmcA:
6.10
3h5gB-2hmcA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		3 / 3 ARG A  21
PRO A  16
PHE A 280
 None
 0.94A 3thrC-2hmcA:
1.5		 3thrC-2hmcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		3 / 3 PHE A 163
VAL A  44
ILE A  10
 None
 0.63A 4emaA-2hmcA:
undetectable		 4emaA-2hmcA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		3 / 3 ALA A 152
GLN A 117
GLY A 111
 None
 0.65A 4odoC-2hmcA:
undetectable		 4odoC-2hmcA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		5 / 6 ALA A  93
ILE A 104
GLY A  77
ILE A 131
VAL A 134
 None
MG  A 502 (-4.8A)
None
None
None
 1.31A 4r21A-2hmcA:
undetectable		 4r21A-2hmcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		4 / 5 ILE A 104
PHE A 280
HIS A 120
ASP A  57
 MG  A 502 (-4.8A)
None
MG  A 502 (-4.6A)
None
 1.27A 4rzvB-2hmcA:
undetectable		 4rzvB-2hmcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		5 / 11 ILE A 190
GLY A 207
GLY A   8
LEU A 223
VAL A 196
 None
 0.91A 5twjD-2hmcA:
undetectable		 5twjD-2hmcA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2hmc DIHYDRODIPICOLINATE
SYNTHASE
(Agrobacterium
fabrum) 		4 / 8 GLY A  77
ILE A 124
GLN A 117
ASP A  57
 None
 0.92A 5vlmH-2hmcA:
undetectable		 5vlmH-2hmcA:
21.75