SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hmf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ALA A 276
GLY A 218
ILE A 217
ILE A 228
ILE A 283
 None
 1.24A 1hshD-2hmfA:
undetectable		 1hshD-2hmfA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 195
THR A 203
ALA A 156
GLY A 209
SER A 213
 None
None
None
ASP  A 502 (-4.2A)
None
 0.96A 1nbiC-2hmfA:
undetectable		 1nbiC-2hmfA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 195
THR A 203
ALA A 156
GLY A 209
SER A 213
 None
None
None
ASP  A 502 (-4.2A)
None
 0.98A 1nbiD-2hmfA:
undetectable		 1nbiD-2hmfA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 462
ILE A 407
THR A 237
 None
 0.81A 1rx3A-2hmfA:
undetectable		 1rx3A-2hmfA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  22
ILE A  18
ILE A 141
VAL A 189
ALA A 150
 None
 1.10A 1uduB-2hmfA:
undetectable		 1uduB-2hmfA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  68
ALA A  48
LEU A 132
ILE A 125
ARG A 122
 None
 1.00A 1xdkB-2hmfA:
undetectable		 1xdkB-2hmfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  68
ALA A  48
LEU A 132
ILE A 125
ARG A 122
 None
 1.00A 1xdkF-2hmfA:
undetectable		 1xdkF-2hmfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 PRO A 188
LEU A 151
GLY A 153
LEU A 178
 None
 0.74A 1ya4A-2hmfA:
undetectable		 1ya4A-2hmfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 7 PRO A 188
LEU A 151
GLY A 153
LEU A 178
 None
 0.66A 1ya4B-2hmfA:
undetectable		 1ya4B-2hmfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 7 LEU A 268
ASP A 211
GLY A   9
VAL A 285
ILE A 228
 None
ADP  A 472 ( 4.3A)
ADP  A 472 (-3.9A)
None
None
 1.41A 2aojB-2hmfA:
undetectable		 2aojB-2hmfA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 10 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.39A 2aquA-2hmfA:
undetectable		 2aquA-2hmfA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 11 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.39A 2aquB-2hmfA:
undetectable		 2aquB-2hmfA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.45A 2fxeA-2hmfA:
undetectable		 2fxeA-2hmfA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 133
VAL A  21
ALA A  22
VAL A 189
VAL A  35
 None
 1.10A 2nniA-2hmfA:
1.6		 2nniA-2hmfA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 210
VAL A  21
ALA A  22
VAL A 189
VAL A  35
 ASP  A 502 (-3.4A)
None
None
None
None
 1.30A 2nniA-2hmfA:
1.6		 2nniA-2hmfA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.41A 2o4kB-2hmfA:
undetectable		 2o4kB-2hmfA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.42A 2q63A-2hmfA:
undetectable		 2q63A-2hmfA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 122
ASP A 123
ILE A 202
GLU A 130
 None
None
None
ASP  A 502 (-3.3A)
 1.32A 2ya7C-2hmfA:
undetectable		 2ya7C-2hmfA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.41A 3bvbB-2hmfA:
undetectable		 3bvbB-2hmfA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 10 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.36A 3ekyA-2hmfA:
undetectable		 3ekyA-2hmfA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.33A 3el1B-2hmfA:
undetectable		 3el1B-2hmfA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 PHE A 449
CYH A 405
LEU A 456
ASP A 455
 None
 1.07A 3m0wE-2hmfA:
undetectable
3m0wF-2hmfA:
1.1
3m0wG-2hmfA:
1.1
3m0wH-2hmfA:
1.0		 3m0wE-2hmfA:
12.22
3m0wF-2hmfA:
12.22
3m0wG-2hmfA:
12.22
3m0wH-2hmfA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A 427
LEU A 463
ILE A 312
ALA A 311
THR A 245
 None
 1.45A 3r9cA-2hmfA:
2.2		 3r9cA-2hmfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		6 / 12 GLY A 139
ALA A 140
ASP A 143
ILE A  97
VAL A  12
ILE A  18
 None
 1.43A 3tl9A-2hmfA:
undetectable		 3tl9A-2hmfA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 350
LEU A 351
TYR A 262
GLY A 264
SER A 313
 None
 1.08A 4bwlC-2hmfA:
undetectable		 4bwlC-2hmfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 462
ILE A 407
THR A 237
 None
 0.86A 4gh8A-2hmfA:
undetectable		 4gh8A-2hmfA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ASN A 360
GLY A 325
ASP A 371
ASP A 397
 None
 1.16A 4n49A-2hmfA:
undetectable		 4n49A-2hmfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 187
VAL A  37
VAL A  39
PHE A   7
MET A   5
 None
 0.96A 4y0sA-2hmfA:
undetectable		 4y0sA-2hmfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 148
GLU A 155
GLU A 103
 None
 0.87A 4ymgB-2hmfA:
4.5		 4ymgB-2hmfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 238
THR A 237
PHE A 467
 None
 0.87A 5cxvA-2hmfA:
undetectable		 5cxvA-2hmfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 457
LEU A 456
ILE A 451
PHE A 449
VAL A 243
 None
 1.27A 5uanB-2hmfA:
undetectable		 5uanB-2hmfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 206
GLY A 209
ILE A 158
THR A 204
ALA A 167
 None
ASP  A 502 (-4.2A)
None
None
None
 0.95A 5vm8B-2hmfA:
undetectable		 5vm8B-2hmfA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A 254
ILE A 298
LEU A 268
GLY A 218
ALA A 215
 None
 1.00A 5zwrA-2hmfA:
undetectable		 5zwrA-2hmfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2hmf PROBABLE
ASPARTOKINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 172
VAL A 174
VAL A   4
VAL A  36
 None
 1.08A 6cp4A-2hmfA:
undetectable		 6cp4A-2hmfA:
22.38