SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.23A 1hrkA-2hmiD:
undetectable		 1hrkA-2hmiD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.23A 1hrkB-2hmiD:
undetectable		 1hrkB-2hmiD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.22A 2hrcB-2hmiD:
undetectable		 2hrcB-2hmiD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D 148
VAL D 173
GLY D 167
VAL D 193
VAL D 191
 None
 0.82A 2ieoB-2hmiD:
undetectable		 2ieoB-2hmiD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.26A 2pnjB-2hmiD:
undetectable		 2pnjB-2hmiD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.18A 2po7B-2hmiD:
undetectable		 2po7B-2hmiD:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA1_0
(FERROCHELATASE)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 11 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.24A 3aqiA-2hmiD:
undetectable		 3aqiA-2hmiD:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.20A 3aqiB-2hmiD:
undetectable		 3aqiB-2hmiD:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		4 / 4 GLN D  16
PRO D  14
VAL D  87
GLU D  88
 None
 1.11A 3huoA-2hmiD:
undetectable		 3huoA-2hmiD:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		5 / 12 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.18A 3w1wA-2hmiD:
undetectable		 3w1wA-2hmiD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		3 / 3 SER D 213
ALA D 208
VAL D 207
 None
 0.56A 4o2bA-2hmiD:
undetectable		 4o2bA-2hmiD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		3 / 3 SER D 213
ALA D 208
VAL D 207
 None
 0.59A 4o2bC-2hmiD:
undetectable		 4o2bC-2hmiD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28
(Mus
musculus) 		3 / 3 SER D 213
ALA D 208
VAL D 207
 None
 0.57A 5eypA-2hmiD:
undetectable		 5eypA-2hmiD:
20.09