SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		6 / 12 ILE A  37
LEU A  66
LEU A  14
GLY A  13
VAL A  42
ALA A  52
 NAI  A 601 (-3.8A)
None
None
NAI  A 601 (-3.3A)
None
None
 1.34A 1axwA-2hmsA:
undetectable		 1axwA-2hmsA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 12 ILE A  12
ILE A  78
LEU A 113
ILE A 116
HIS A 109
 None
NAI  A 601 (-3.9A)
None
None
None
 1.11A 1bsxA-2hmsA:
undetectable		 1bsxA-2hmsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 12 ILE A  12
ILE A  78
LEU A 113
ILE A 116
HIS A 109
 None
NAI  A 601 (-3.9A)
None
None
None
 1.11A 1bsxB-2hmsA:
undetectable		 1bsxB-2hmsA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 12 ILE A  37
LEU A  66
GLY A  13
VAL A  42
ALA A  52
 NAI  A 601 (-3.8A)
None
NAI  A 601 (-3.3A)
None
None
 0.95A 1tlsA-2hmsA:
undetectable		 1tlsA-2hmsA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		6 / 12 ILE A  37
LEU A  66
LEU A  14
GLY A  13
VAL A  42
ALA A  52
 NAI  A 601 (-3.8A)
None
None
NAI  A 601 (-3.3A)
None
None
 1.34A 1tlsB-2hmsA:
undetectable		 1tlsB-2hmsA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		6 / 12 ILE A  37
LEU A  66
LEU A  14
GLY A  13
VAL A  42
ALA A  52
 NAI  A 601 (-3.8A)
None
None
NAI  A 601 (-3.3A)
None
None
 1.35A 1tsnA-2hmsA:
undetectable		 1tsnA-2hmsA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		4 / 5 ALA A  49
TYR A  48
ALA A  52
TYR A  45
 None
 1.07A 1xl6A-2hmsA:
undetectable
1xl6B-2hmsA:
undetectable		 1xl6A-2hmsA:
17.94
1xl6B-2hmsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 12 GLY A  13
GLY A  15
ILE A  37
ASN A  56
ALA A  57
 NAI  A 601 (-3.3A)
NAI  A 601 (-3.2A)
NAI  A 601 (-3.8A)
NAI  A 601 (-3.6A)
NAI  A 601 (-3.8A)
 1.08A 2vdvE-2hmsA:
6.4		 2vdvE-2hmsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 11 GLY A  13
GLY A  15
ILE A  37
ASN A  56
ALA A  57
 NAI  A 601 (-3.3A)
NAI  A 601 (-3.2A)
NAI  A 601 (-3.8A)
NAI  A 601 (-3.6A)
NAI  A 601 (-3.8A)
 1.09A 2vdvF-2hmsA:
6.4		 2vdvF-2hmsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		4 / 4 ALA A  49
TYR A  48
ALA A  52
TYR A  45
 None
 1.11A 2wlkA-2hmsA:
undetectable
2wlkB-2hmsA:
undetectable		 2wlkA-2hmsA:
17.94
2wlkB-2hmsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 12 GLY A  13
GLY A  15
ILE A  37
ASN A  56
ALA A  57
 NAI  A 601 (-3.3A)
NAI  A 601 (-3.2A)
NAI  A 601 (-3.8A)
NAI  A 601 (-3.6A)
NAI  A 601 (-3.8A)
 1.15A 3ckkA-2hmsA:
6.9		 3ckkA-2hmsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 12 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
NAI  A 601 (-3.3A)
None
NAI  A 601 (-3.8A)
None
 0.57A 3fpjA-2hmsA:
5.9		 3fpjA-2hmsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		4 / 5 LEU A 113
GLN A  83
THR A  86
HIS A 123
 None
 1.46A 3n58C-2hmsA:
6.8		 3n58C-2hmsA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		4 / 6 THR A  50
ALA A  49
VAL A  22
HIS A  51
 None
 0.88A 5ecoA-2hmsA:
2.0		 5ecoA-2hmsA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		3 / 3 ASP A  36
ASN A  56
PHE A  17
 NAI  A 601 (-2.9A)
NAI  A 601 (-3.6A)
None
 0.81A 5jglB-2hmsA:
6.1		 5jglB-2hmsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 9 ILE A  21
LEU A  14
GLY A  15
PHE A  17
ALA A  44
 None
None
NAI  A 601 (-3.2A)
None
None
 1.25A 5x66C-2hmsA:
undetectable		 5x66C-2hmsA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 9 ILE A  75
LEU A  14
GLY A  19
PHE A  17
ALA A  49
 None
 1.39A 5x66C-2hmsA:
undetectable		 5x66C-2hmsA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		5 / 9 ILE A  75
LEU A  14
GLY A  19
PHE A  17
ALA A  52
 None
 1.11A 5x66C-2hmsA:
undetectable		 5x66C-2hmsA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		4 / 8 ILE A  75
VAL A  22
ALA A  49
THR A  50
 None
 0.75A 6cduD-2hmsA:
undetectable
6cduE-2hmsA:
undetectable		 6cduD-2hmsA:
16.98
6cduE-2hmsA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2hms YUAA PROTEIN
(Bacillus
subtilis) 		4 / 7 ALA A  49
THR A  50
ILE A  75
VAL A  22
 None
 0.80A 6cduF-2hmsA:
undetectable
6cduJ-2hmsA:
undetectable		 6cduF-2hmsA:
16.98
6cduJ-2hmsA:
16.98