SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 113
ILE A 152
ARG A 153
VAL A 138
 None
 1.11A 1db1A-2hn1A:
undetectable		 1db1A-2hn1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		3 / 3 ILE A  31
ILE A  67
THR A  29
 None
 0.62A 1rg7A-2hn1A:
undetectable		 1rg7A-2hn1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 GLY A  49
GLU A 142
LEU A  51
PHE A  84
THR A 140
 None
 1.00A 3mteB-2hn1A:
undetectable		 3mteB-2hn1A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 9 ALA A  79
ILE A  95
GLY A  86
VAL A  69
ILE A  78
 None
 1.10A 3nu4A-2hn1A:
undetectable		 3nu4A-2hn1A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 180
ASP A 176
TYR A 169
ARG A 161
 None
 1.28A 3s3oA-2hn1A:
undetectable		 3s3oA-2hn1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 10 ILE A  95
PHE A 141
THR A  29
ILE A  31
ILE A  78
 None
 1.15A 3um5A-2hn1A:
undetectable		 3um5A-2hn1A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 131
ILE A  31
ILE A  67
VAL A 138
LEU A 137
 None
 1.05A 3w67B-2hn1A:
undetectable		 3w67B-2hn1A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 255
ARG A 237
SER A 233
 None
 1.03A 4khpI-2hn1A:
undetectable
4khpJ-2hn1A:
undetectable		 4khpI-2hn1A:
19.92
4khpJ-2hn1A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2hn1 MAGNESIUM AND COBALT
TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 8 THR A  29
GLU A  23
VAL A  19
LEU A  96
GLY A  71
 None
 1.43A 4r3aA-2hn1A:
undetectable		 4r3aA-2hn1A:
22.31