SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 6 GLU A 333
THR A  94
ALA A  90
LEU A  86
 None
 1.20A 1etb2-2hneA:
undetectable		 1etb2-2hneA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 7 GLY A 409
PRO A 131
SER A 411
ALA A 404
 None
 0.91A 1gxsA-2hneA:
undetectable
1gxsB-2hneA:
undetectable		 1gxsA-2hneA:
19.28
1gxsB-2hneA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 ILE A 323
GLY A 300
ILE A 337
GLU A 333
 None
 0.83A 1mrjA-2hneA:
undetectable		 1mrjA-2hneA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 10 ASP A 324
PRO A 186
ALA A 187
TYR A 402
TYR A 185
 None
 1.25A 1mskA-2hneA:
0.0		 1mskA-2hneA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 4 HIS A  10
VAL A  38
THR A  64
LEU A  70
 None
 1.36A 1oq5A-2hneA:
undetectable		 1oq5A-2hneA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 ASP A  46
LEU A  47
HIS A 363
 None
 0.75A 1qknA-2hneA:
undetectable		 1qknA-2hneA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 7 LEU A 387
VAL A 355
GLY A 354
ASP A  31
 None
 0.81A 1t88A-2hneA:
undetectable		 1t88A-2hneA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 LEU A 387
VAL A 355
GLY A 354
ASP A  31
 None
 0.79A 2a1oA-2hneA:
undetectable		 2a1oA-2hneA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 9 LEU A  93
PHE A  89
LEU A  70
LEU A   7
ALA A 115
 None
 1.30A 2bxeA-2hneA:
undetectable		 2bxeA-2hneA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 VAL A 116
VAL A  38
ASP A  80
 None
 0.74A 2fumD-2hneA:
undetectable		 2fumD-2hneA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		6 / 12 LEU A  77
ALA A 120
ASP A 122
GLY A 114
ILE A 113
VAL A  74
 None
 1.43A 2ieoA-2hneA:
undetectable		 2ieoA-2hneA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 9 ILE A 136
ALA A 371
GLU A 406
GLY A 184
LEU A 180
 None
 1.21A 2v0mB-2hneA:
undetectable		 2v0mB-2hneA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 8 ALA A 325
GLY A 356
LEU A  52
GLY A  51
ASP A 122
 None
 1.44A 2yfxA-2hneA:
undetectable		 2yfxA-2hneA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 CYH A 358
PRO A 394
ASP A 385
 None
 0.43A 3hlwB-2hneA:
undetectable		 3hlwB-2hneA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 GLY A 356
ILE A 419
PHE A 429
PHE A  14
 None
 1.04A 3ko0B-2hneA:
undetectable
3ko0J-2hneA:
undetectable		 3ko0B-2hneA:
13.63
3ko0J-2hneA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 GLY A 356
ILE A 419
PHE A 429
PHE A  14
 None
 0.95A 3ko0K-2hneA:
undetectable
3ko0S-2hneA:
undetectable		 3ko0K-2hneA:
13.63
3ko0S-2hneA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 HIS A 415
PHE A 422
PHE A  14
 None
 0.70A 3lk0D-2hneA:
undetectable		 3lk0D-2hneA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 LYS A 130
PRO A 131
LEU A 132
 None
 0.85A 3tpxE-2hneA:
undetectable		 3tpxE-2hneA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 ASP A  11
GLY A  59
TYR A 424
 None
 0.75A 3w9tC-2hneA:
undetectable		 3w9tC-2hneA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 ASP A  11
GLY A  59
TYR A 424
 None
 0.74A 3w9tG-2hneA:
undetectable		 3w9tG-2hneA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 6 GLU A 333
ILE A 337
ASN A 334
GLU A 274
 None
None
None
MG  A 601 (-3.1A)
 1.12A 4ejwB-2hneA:
undetectable		 4ejwB-2hneA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 LEU A 357
ARG A 327
VAL A  53
GLN A  63
 None
 0.96A 4em2A-2hneA:
undetectable		 4em2A-2hneA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 ALA A 127
VAL A  79
GLY A  49
ILE A  83
 None
 0.75A 4ll3A-2hneA:
undetectable		 4ll3A-2hneA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 CYH A 358
PRO A 394
ASP A 385
 None
 0.43A 4pm5A-2hneA:
undetectable		 4pm5A-2hneA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		6 / 12 LEU A 153
ALA A 156
LEU A 313
THR A 303
ALA A 336
ILE A 321
 None
 1.48A 4x20B-2hneA:
2.5		 4x20B-2hneA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		3 / 3 LYS A 218
ARG A 347
VAL A 348
 MG  A 601 ( 3.7A)
None
None
 0.81A 4x3uA-2hneA:
undetectable
4x3uB-2hneA:
undetectable		 4x3uA-2hneA:
9.88
4x3uB-2hneA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 ILE A 270
VAL A 295
GLN A 264
GLU A 267
 None
 1.07A 5dqyA-2hneA:
undetectable		 5dqyA-2hneA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 12 PHE A 391
MET A 111
LEU A 357
ILE A  56
ALA A  35
 None
 1.26A 5ienA-2hneA:
undetectable		 5ienA-2hneA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 12 LEU A 153
PHE A 150
LEU A 166
LEU A 144
ALA A 342
 None
 1.27A 5ieoA-2hneA:
undetectable		 5ieoA-2hneA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 12 PRO A  15
SER A  33
PHE A 422
ARG A  13
GLY A 427
 None
 1.35A 5il1A-2hneA:
undetectable		 5il1A-2hneA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 LEU A  39
PHE A  89
LEU A  70
ILE A 113
 None
 1.02A 5mzjA-2hneA:
undetectable		 5mzjA-2hneA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 10 ARG A  40
ALA A  48
LEU A  39
ILE A 136
LEU A 144
 None
 1.26A 5oy01-2hneA:
undetectable
5oy07-2hneA:
undetectable		 5oy01-2hneA:
10.02
5oy07-2hneA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.86A 5sxqA-2hneA:
undetectable		 5sxqA-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.81A 5sxqB-2hneA:
undetectable		 5sxqB-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.83A 5sxtA-2hneA:
undetectable		 5sxtA-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.80A 5sxtB-2hneA:
undetectable		 5sxtB-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.85A 5syjA-2hneA:
undetectable		 5syjA-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 8 VAL A 116
GLY A  76
LEU A  77
THR A   3
 None
 0.80A 5syjB-2hneA:
undetectable		 5syjB-2hneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		5 / 11 ASP A 324
PRO A 186
ALA A 187
TYR A 402
TYR A 185
 None
 1.28A 6bm5A-2hneA:
0.0		 6bm5A-2hneA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 5 THR A 177
LEU A 144
VAL A 331
LEU A 338
 None
 0.92A 6bqgA-2hneA:
undetectable		 6bqgA-2hneA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 6 LEU A 132
ALA A 125
LEU A 335
THR A 147
 None
 0.95A 6f88B-2hneA:
undetectable		 6f88B-2hneA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2hne L-FUCONATE
DEHYDRATASE
(Xanthomonas
campestris) 		4 / 7 ASP A 368
ARG A 379
TYR A 185
ASP A 378
 None
 1.18A 6mn5E-2hneA:
undetectable		 6mn5E-2hneA:
9.74