SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hnh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 ILE A 522
THR A 523
PRO A 537
LEU A 528
 None
 0.84A 1hmyA-2hnhA:
undetectable		 1hmyA-2hnhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A  67
ASP A  69
SER A  16
ILE A  65
LEU A  39
 None
 1.33A 1lhuA-2hnhA:
undetectable		 1lhuA-2hnhA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A 557
ASP A 405
GLY A 361
PRO A 360
HIS A 760
 None
 1.41A 1tmxA-2hnhA:
undetectable		 1tmxA-2hnhA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 557
ASP A 405
GLY A 361
PRO A 360
HIS A 760
 None
 1.42A 1tmxB-2hnhA:
undetectable		 1tmxB-2hnhA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
 None
 0.93A 1xdkB-2hnhA:
undetectable		 1xdkB-2hnhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A  97
LEU A 100
ILE A 101
ARG A 107
LEU A 128
 None
 0.93A 1xdkF-2hnhA:
undetectable		 1xdkF-2hnhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 10 ILE A 564
ALA A 785
ALA A 568
PHE A 782
ALA A 784
 None
 1.16A 2aclC-2hnhA:
undetectable		 2aclC-2hnhA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 10 ALA A 776
GLN A 610
LEU A 611
SER A 596
LEU A 772
 None
 1.25A 2ceoB-2hnhA:
undetectable		 2ceoB-2hnhA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 HIS A  12
ILE A  41
LEU A  47
 None
 0.75A 2kceA-2hnhA:
undetectable		 2kceA-2hnhA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 9 ARG A 362
GLY A 365
ILE A 348
VAL A 404
VAL A 515
 None
 1.19A 2nnhB-2hnhA:
undetectable		 2nnhB-2hnhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 10 THR A 539
VAL A 516
VAL A 515
ILE A 431
VAL A 538
 None
 1.44A 2qboA-2hnhA:
undetectable		 2qboA-2hnhA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 5 LEU A 637
ASP A 630
ALA A 633
ILE A 652
 None
 1.05A 2qhfA-2hnhA:
undetectable		 2qhfA-2hnhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 HIS A   8
MET A  36
MET A 240
 None
 1.10A 2vj1A-2hnhA:
undetectable		 2vj1A-2hnhA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 404
VAL A 418
TYR A 422
VAL A 552
 None
 1.08A 2y05A-2hnhA:
undetectable
2y05B-2hnhA:
undetectable		 2y05A-2hnhA:
18.23
2y05B-2hnhA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 TYR A  54
VAL A  66
THR A 270
 None
 0.79A 2ygnA-2hnhA:
undetectable		 2ygnA-2hnhA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 THR A  85
LEU A  87
THR A  24
VAL A  28
LEU A  39
 None
 1.40A 3a51B-2hnhA:
3.3		 3a51B-2hnhA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 LEU A 865
PHE A 888
VAL A 878
ALA A 887
 None
 0.99A 3ax9A-2hnhA:
undetectable		 3ax9A-2hnhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 GLU A 389
SER A 368
VAL A 370
 None
 0.76A 3eeoA-2hnhA:
undetectable		 3eeoA-2hnhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 9 ASP A 815
GLY A 886
ILE A 883
VAL A 841
ILE A 835
 None
 1.21A 3ekyB-2hnhA:
undetectable		 3ekyB-2hnhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 GLY A  67
ALA A  68
ASP A  69
ILE A 101
 None
 0.64A 3el0A-2hnhA:
undetectable		 3el0A-2hnhA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 5 ILE A  62
TYR A  54
ILE A  65
HIS A   8
 None
 0.93A 3eteB-2hnhA:
undetectable
3eteC-2hnhA:
undetectable		 3eteB-2hnhA:
21.31
3eteC-2hnhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A 816
GLY A 819
PRO A 814
PHE A 888
ILE A 850
 None
 1.08A 3jayA-2hnhA:
undetectable		 3jayA-2hnhA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 VAL A 271
ILE A 431
ALA A 549
LEU A 273
 None
 0.91A 3kk6B-2hnhA:
undetectable		 3kk6B-2hnhA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 LEU A 131
PHE A 167
ILE A 263
CYH A 267
 None
 1.00A 3ko0B-2hnhA:
undetectable		 3ko0B-2hnhA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 HIS A   8
ASN A 200
MET A 240
LYS A  30
 None
 1.35A 3kp6A-2hnhA:
undetectable
3kp6B-2hnhA:
undetectable		 3kp6A-2hnhA:
12.13
3kp6B-2hnhA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 9 PHE A 250
LEU A 194
LEU A  87
TYR A 158
VAL A 139
 None
 1.50A 3m7rA-2hnhA:
0.0		 3m7rA-2hnhA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 9 LEU A 865
PHE A 888
LEU A 902
ILE A 883
GLU A 880
 None
 1.11A 3mdvA-2hnhA:
undetectable		 3mdvA-2hnhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A 205
ALA A  22
ILE A  41
ALA A  40
GLY A  57
 None
 1.05A 3nxuA-2hnhA:
undetectable		 3nxuA-2hnhA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 TYR A 239
GLU A 214
TYR A 234
 None
 1.00A 3ug8A-2hnhA:
undetectable		 3ug8A-2hnhA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 133
GLY A 134
ASP A  69
ASP A  43
VAL A 202
 None
PO4  A 911 ( 4.1A)
None
None
None
 1.12A 4b17A-2hnhA:
undetectable		 4b17A-2hnhA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 9 LEU A 874
LYS A 873
VAL A 841
GLY A 842
LEU A 879
 None
 1.38A 4b3oA-2hnhA:
undetectable		 4b3oA-2hnhA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 PHE A 628
ASP A 378
ILE A 348
GLY A 361
GLN A 610
 None
 1.34A 4djfB-2hnhA:
2.3		 4djfB-2hnhA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		6 / 12 LEU A  97
LEU A 100
ILE A 101
ARG A 107
GLY A  67
LEU A 131
 None
 1.33A 4dm8B-2hnhA:
undetectable		 4dm8B-2hnhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 ASP A  14
ASP A  43
ASP A 542
ASN A  46
 None
None
PO4  A 912 ( 2.9A)
None
 1.34A 4gkhJ-2hnhA:
undetectable		 4gkhJ-2hnhA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		6 / 12 VAL A 676
LEU A 702
GLN A 695
MET A 691
ILE A 684
ALA A 752
 None
 1.28A 4ltwA-2hnhA:
undetectable		 4ltwA-2hnhA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 203
HIS A 213
SER A  16
 None
 0.97A 4mjwA-2hnhA:
undetectable
4mjwB-2hnhA:
0.0		 4mjwA-2hnhA:
23.14
4mjwB-2hnhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 SER A  16
ARG A 203
HIS A 213
 None
 0.99A 4mjwA-2hnhA:
undetectable
4mjwB-2hnhA:
0.0		 4mjwA-2hnhA:
23.14
4mjwB-2hnhA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 PHE A 888
ILE A 816
ARG A 853
VAL A 841
 None
 1.22A 4mk4B-2hnhA:
undetectable		 4mk4B-2hnhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 628
ASP A 592
PRO A 625
ILE A 589
 None
 0.98A 4pcuA-2hnhA:
undetectable		 4pcuA-2hnhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 7 ALA A 526
GLY A 550
ALA A 549
GLU A 547
 None
 0.89A 4r1zB-2hnhA:
undetectable		 4r1zB-2hnhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 7 LEU A 584
LEU A 774
ASN A 566
ILE A 565
 None
 0.68A 4rmjA-2hnhA:
undetectable		 4rmjA-2hnhA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A 387
LEU A 673
GLN A 692
LEU A 702
ALA A 705
 None
 1.17A 4wnuA-2hnhA:
undetectable		 4wnuA-2hnhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 ARG A 303
ARG A 362
ASP A 378
VAL A 370
 None
 1.09A 4xqeB-2hnhA:
undetectable		 4xqeB-2hnhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 ARG A 303
ARG A 362
ASP A 378
VAL A 370
 None
 1.08A 4xqgA-2hnhA:
undetectable		 4xqgA-2hnhA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 ARG A 303
ARG A 362
ASP A 378
VAL A 370
 None
 1.08A 4xqgB-2hnhA:
undetectable		 4xqgB-2hnhA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 5 PHE A 556
ASP A 405
PHE A 406
VAL A 515
 None
 1.20A 5a1rA-2hnhA:
2.0		 5a1rA-2hnhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 8 TYR A 548
LEU A 273
PHE A 541
GLY A  49
THR A  24
 None
 1.44A 5eseA-2hnhA:
0.1		 5eseA-2hnhA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 ALA A  33
PRO A  37
LEU A   9
HIS A   8
 None
 1.49A 5eskA-2hnhA:
3.3		 5eskA-2hnhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_A_URFA301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 ARG A 203
ASP A  19
HIS A  83
ARG A  10
 None
None
PO4  A 911 (-3.6A)
PO4  A 911 (-2.8A)
 1.35A 5iaoA-2hnhA:
0.0		 5iaoA-2hnhA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 7 GLY A 140
GLY A 134
GLY A 133
VAL A 139
LEU A  84
 None
PO4  A 911 ( 4.1A)
None
None
None
 1.34A 5izjB-2hnhA:
undetectable		 5izjB-2hnhA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A 332
PRO A 400
LEU A 392
PHE A 341
GLY A 339
 None
 1.18A 5l6eA-2hnhA:
undetectable		 5l6eA-2hnhA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.05A 5m45A-2hnhA:
undetectable		 5m45A-2hnhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.10A 5m45D-2hnhA:
undetectable		 5m45D-2hnhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.04A 5m45G-2hnhA:
undetectable		 5m45G-2hnhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 GLU A 478
PRO A 464
ILE A 463
LEU A 462
 None
 1.14A 5m45J-2hnhA:
undetectable		 5m45J-2hnhA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 VAL A 552
GLU A 547
LEU A 292
GLN A 334
LEU A 392
 None
 1.31A 5m50E-2hnhA:
undetectable		 5m50E-2hnhA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.81A 5sxqA-2hnhA:
undetectable		 5sxqA-2hnhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.79A 5sxqB-2hnhA:
2.2		 5sxqB-2hnhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.83A 5sxtA-2hnhA:
undetectable		 5sxtA-2hnhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.82A 5sxtB-2hnhA:
undetectable		 5sxtB-2hnhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.78A 5syjA-2hnhA:
undetectable		 5syjA-2hnhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 331
GLY A 339
LEU A 292
THR A 288
 None
 0.78A 5syjB-2hnhA:
2.1		 5syjB-2hnhA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A  68
GLU A 169
LEU A 130
ILE A 129
ARG A 266
 None
 1.32A 5vlmG-2hnhA:
undetectable		 5vlmG-2hnhA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		3 / 3 GLY A 703
ASN A 393
ARG A 709
 None
 0.66A 5w7bD-2hnhA:
undetectable		 5w7bD-2hnhA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 LEU A 168
VAL A 139
LEU A 143
VAL A 155
 None
 0.95A 5x7zA-2hnhA:
undetectable		 5x7zA-2hnhA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 VAL A 197
LEU A 170
LEU A 182
ASP A 252
 None
 1.25A 5xv7A-2hnhA:
0.6		 5xv7A-2hnhA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 ALA A 587
LYS A 375
GLN A 349
ASP A 353
 None
 1.48A 5y9aA-2hnhA:
undetectable		 5y9aA-2hnhA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A 852
GLY A 856
THR A 869
LEU A 874
ASN A 854
 None
 1.16A 5ybbA-2hnhA:
undetectable		 5ybbA-2hnhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 VAL A 404
GLY A 361
ALA A 763
SER A 351
GLU A 346
 None
 1.11A 6bqgA-2hnhA:
undetectable		 6bqgA-2hnhA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 10 LEU A 879
GLY A 840
ILE A 838
ILE A 816
ILE A 849
 None
 1.10A 6ebpD-2hnhA:
undetectable		 6ebpD-2hnhA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A 879
GLY A 840
ILE A 838
ILE A 816
ILE A 849
 None
 1.08A 6ebzD-2hnhA:
undetectable		 6ebzD-2hnhA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 THR A 173
PRO A 176
ARG A 135
ILE A 171
 None
None
PO4  A 911 (-4.1A)
PO4  A 911 (-4.3A)
 1.32A 6ef6A-2hnhA:
undetectable		 6ef6A-2hnhA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_ACTA512_0
(MULTIDRUG
TRANSPORTER MDFA)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 4 ARG A 317
GLU A 383
LEU A 382
ASP A 380
 None
 1.43A 6euqA-2hnhA:
0.3		 6euqA-2hnhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		4 / 6 LEU A 249
LEU A 182
THR A 199
ARG A 141
 None
 1.10A 6ew0G-2hnhA:
undetectable		 6ew0G-2hnhA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2hnh DNA POLYMERASE III
ALPHA SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 509
TYR A  15
PRO A  26
VAL A 538
GLY A 513
 None
 1.21A 6gngA-2hnhA:
undetectable		 6gngA-2hnhA:
22.39