SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hnk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		3 / 3 THR A 124
LEU A 125
LEU A 171
 None
 0.57A 1mz9C-2hnkA:
undetectable		 1mz9C-2hnkA:
11.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		9 / 12 GLY A  68
PHE A  70
TYR A  73
SER A  74
VAL A  93
ALA A 121
ALA A 155
ASP A 156
TYR A 163
 SAH  A2001 (-3.3A)
SAH  A2001 (-4.4A)
None
SAH  A2001 (-2.9A)
SAH  A2001 (-4.1A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
SAH  A2001 (-3.1A)
None
 0.62A 2avdA-2hnkA:
29.5		 2avdA-2hnkA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		8 / 12 GLY A  68
PHE A  70
TYR A  73
VAL A  93
ALA A 121
ASP A 154
ALA A 155
TYR A 163
 SAH  A2001 (-3.3A)
SAH  A2001 (-4.4A)
None
SAH  A2001 (-4.1A)
SAH  A2001 (-3.3A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
None
 0.57A 2avdB-2hnkA:
29.9		 2avdB-2hnkA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 GLU A  66
GLY A  68
SER A  74
ASP A  92
ALA A 155
 SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
SAH  A2001 (-2.9A)
SAH  A2001 (-3.0A)
SAH  A2001 ( 3.8A)
 1.15A 2br4D-2hnkA:
12.6		 2br4D-2hnkA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 LEU A  55
LEU A 218
SER A 226
LEU A 227
VAL A 228
 None
 1.14A 2c12C-2hnkA:
undetectable		 2c12C-2hnkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		3 / 3 TYR A 164
ASP A 215
ASP A 211
 None
SO4  A1001 ( 4.8A)
None
 0.57A 3r24A-2hnkA:
9.6		 3r24A-2hnkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		5 / 10 MET A  42
GLU A  66
GLY A  68
SER A  74
ASP A 154
 SAH  A2001 (-3.9A)
SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
SAH  A2001 (-2.9A)
SAH  A2001 (-3.3A)
 0.41A 3s68A-2hnkA:
22.5		 3s68A-2hnkA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_TCWA227_1
(CATECHOL
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		5 / 10 MET A  42
ASP A 154
LYS A 157
ASP A 180
ASN A 181
 SAH  A2001 (-3.9A)
SAH  A2001 (-3.3A)
None
None
None
 0.32A 3s68A-2hnkA:
15.5		 3s68A-2hnkA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 PHE A 152
VAL A 225
ILE A 221
GLU A  66
 None
None
None
SAH  A2001 ( 4.2A)
 0.98A 4a97G-2hnkA:
undetectable		 4a97G-2hnkA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 PHE A 152
VAL A 225
ILE A 221
GLU A  66
 None
None
None
SAH  A2001 ( 4.2A)
 1.13A 4a97H-2hnkA:
undetectable		 4a97H-2hnkA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		4 / 6 GLU A 233
ARG A 231
ASP A 215
ARG A 229
 None
SO4  A1001 (-3.6A)
SO4  A1001 ( 4.8A)
SO4  A1001 (-2.6A)
 1.33A 4kcnA-2hnkA:
undetectable		 4kcnA-2hnkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		4 / 6 GLU A 233
ARG A 231
ASP A 215
ARG A 229
 None
SO4  A1001 (-3.6A)
SO4  A1001 ( 4.8A)
SO4  A1001 (-2.6A)
 1.32A 4kcnB-2hnkA:
1.7		 4kcnB-2hnkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		5 / 12 GLU A  66
GLY A  68
ALA A 121
ALA A 155
TYR A 163
 SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
None
 0.43A 4pclB-2hnkA:
28.2		 4pclB-2hnkA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PYL_A_TCWA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		5 / 10 MET A  42
ASP A 154
LYS A 157
ASP A 180
ASN A 181
 SAH  A2001 (-3.9A)
SAH  A2001 (-3.3A)
None
None
None
 0.32A 4pylA-2hnkA:
23.4		 4pylA-2hnkA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		6 / 12 GLY A  68
TYR A  73
SER A  94
ALA A 121
ALA A 155
TYR A 163
 SAH  A2001 (-3.3A)
None
None
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
None
 0.66A 4ymgA-2hnkA:
24.8		 4ymgA-2hnkA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		8 / 12 GLY A  68
TYR A  73
SER A  74
SER A  94
ALA A 121
ASP A 154
ALA A 155
TYR A 163
 SAH  A2001 (-3.3A)
None
SAH  A2001 (-2.9A)
None
SAH  A2001 (-3.3A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
None
 0.60A 4ymgB-2hnkA:
25.2		 4ymgB-2hnkA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 PHE A  78
SER A  80
ALA A  79
LEU A  76
 None
 1.16A 5dzkD-2hnkA:
undetectable
5dzkR-2hnkA:
undetectable		 5dzkD-2hnkA:
22.44
5dzkR-2hnkA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		4 / 8 ILE A  67
GLY A  68
PHE A  51
ASP A 180
 None
SAH  A2001 (-3.3A)
None
None
 0.89A 5hieD-2hnkA:
undetectable		 5hieD-2hnkA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		9 / 12 MET A  42
GLU A  66
GLY A  68
TYR A  73
ALA A 121
ASP A 154
ALA A 155
ASP A 156
TYR A 163
 SAH  A2001 (-3.9A)
SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
None
SAH  A2001 (-3.3A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
SAH  A2001 (-3.1A)
None
 0.44A 5kvaA-2hnkA:
25.6		 5kvaA-2hnkA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		6 / 12 THR A  71
GLU A  66
GLY A  68
ALA A 155
ASP A 156
TYR A 163
 None
SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
SAH  A2001 (-3.1A)
None
 1.30A 5kvaA-2hnkA:
25.6		 5kvaA-2hnkA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		9 / 12 MET A  42
GLU A  66
GLY A  68
TYR A  73
ALA A 121
ASP A 154
ALA A 155
ASP A 156
TYR A 163
 SAH  A2001 (-3.9A)
SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
None
SAH  A2001 (-3.3A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
SAH  A2001 (-3.1A)
None
 0.52A 5kvaB-2hnkA:
29.8		 5kvaB-2hnkA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		6 / 12 THR A  71
GLU A  66
GLY A  68
ALA A 155
ASP A 156
TYR A 163
 None
SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
SAH  A2001 ( 3.8A)
SAH  A2001 (-3.1A)
None
 1.31A 5kvaB-2hnkA:
29.8		 5kvaB-2hnkA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LOG_A_LDPA1004_1
(PUTATIVE
O-METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		6 / 6 MET A  42
ASP A 154
LYS A 157
ASP A 180
ASN A 181
TRP A 184
 SAH  A2001 (-3.9A)
SAH  A2001 (-3.3A)
None
None
None
PEG  A3004 (-3.6A)
 0.30A 5logA-2hnkA:
32.3		 5logA-2hnkA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		7 / 12 GLU A  66
GLY A  68
TYR A  73
ALA A 121
PHE A 152
ALA A 155
TYR A 163
 SAH  A2001 ( 4.2A)
SAH  A2001 (-3.3A)
None
SAH  A2001 (-3.3A)
None
SAH  A2001 ( 3.8A)
None
 0.44A 5n5dA-2hnkA:
28.2		 5n5dA-2hnkA:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		6 / 12 GLU A  66
TYR A  73
ALA A 121
PHE A 152
ALA A 155
TYR A 163
 SAH  A2001 ( 4.2A)
None
SAH  A2001 (-3.3A)
None
SAH  A2001 ( 3.8A)
None
 0.48A 5n5dB-2hnkA:
28.1		 5n5dB-2hnkA:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		4 / 7 GLY A  68
PHE A  70
SER A  74
ASP A 154
 SAH  A2001 (-3.3A)
SAH  A2001 (-4.4A)
SAH  A2001 (-2.9A)
SAH  A2001 (-3.3A)
 0.34A 5n5dB-2hnkA:
28.1		 5n5dB-2hnkA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE
(Leptospira
interrogans) 		5 / 11 LEU A 153
ASP A 180
ILE A  67
GLY A  68
LEU A 177
 None
None
None
SAH  A2001 (-3.3A)
None
 0.94A 5twjD-2hnkA:
undetectable		 5twjD-2hnkA:
23.08