SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 7 TYR A  32
PHE A  33
ARG A  38
ILE A 127
 None
None
GSH  A 501 (-4.3A)
None
 0.61A 11gsA-2hnlA:
25.5		 11gsA-2hnlA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 7 TYR A  32
PHE A  33
GLY A  37
ARG A  38
ILE A 127
 None
None
None
GSH  A 501 (-4.3A)
None
 0.62A 11gsB-2hnlA:
25.5		 11gsB-2hnlA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 12 PHE A  46
LEU A  48
ALA A  49
LEU A 101
LEU A  78
 None
 1.12A 1og5A-2hnlA:
undetectable		 1og5A-2hnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 6 ARG A  43
ALA A  39
ILE A  91
PRO A  76
 None
None
None
GSH  A 501 (-4.4A)
 1.28A 1oniB-2hnlA:
undetectable
1oniC-2hnlA:
undetectable		 1oniB-2hnlA:
20.00
1oniC-2hnlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 12 LEU A  48
GLY A 100
LEU A 102
GLY A 103
LYS A 173
 None
 1.25A 1y4lA-2hnlA:
undetectable		 1y4lA-2hnlA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
ARG A  38
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-4.3A)
GSH  A 501 (-3.9A)
None
 0.69A 2gssA-2hnlA:
25.5		 2gssA-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
ARG A  38
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-4.3A)
GSH  A 501 (-3.9A)
None
 0.69A 2gssB-2hnlA:
25.4		 2gssB-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 12 PHE A  33
GLY A  37
GLY A  35
VAL A  41
PRO A  76
 None
None
None
None
GSH  A 501 (-4.4A)
 1.11A 2zulA-2hnlA:
undetectable		 2zulA-2hnlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 9 TYR A  32
PHE A  33
GLY A  37
ARG A  38
ILE A 127
 None
None
None
GSH  A 501 (-4.3A)
None
 0.61A 3csjB-2hnlA:
25.5		 3csjB-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 TYR A  32
PHE A  33
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-3.9A)
None
 0.52A 3hjoA-2hnlA:
25.5		 3hjoA-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 PHE A 142
GLU A 147
SER A 148
MET A 151
 None
 1.25A 3jx1A-2hnlA:
undetectable
3jx1B-2hnlA:
undetectable		 3jx1A-2hnlA:
19.06
3jx1B-2hnlA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 10 TYR A  32
PHE A  33
GLY A  37
TRP A  63
ILE A 127
 None
None
None
GSH  A 501 (-3.9A)
None
 0.69A 3km6A-2hnlA:
25.3		 3km6A-2hnlA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
ARG A  38
TRP A  63
ILE A 127
 None
None
GSH  A 501 (-4.3A)
GSH  A 501 (-3.9A)
None
 0.69A 3n9jA-2hnlA:
25.4		 3n9jA-2hnlA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		5 / 8 TYR A  32
PHE A  33
GLY A  37
ARG A  38
ILE A 127
 None
None
None
GSH  A 501 (-4.3A)
None
 0.59A 3n9jB-2hnlA:
25.3		 3n9jB-2hnlA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 PHE A 142
GLU A 147
SER A 148
MET A 151
 None
 1.28A 3nlyA-2hnlA:
undetectable
3nlyB-2hnlA:
undetectable		 3nlyA-2hnlA:
18.62
3nlyB-2hnlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 PHE A 142
GLU A 147
SER A 148
MET A 151
 None
 1.28A 3rqlA-2hnlA:
undetectable
3rqlB-2hnlA:
undetectable		 3rqlA-2hnlA:
18.62
3rqlB-2hnlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 5 LEU A 102
THR A 180
ILE A  42
VAL A  41
 None
 0.89A 3wriA-2hnlA:
undetectable		 3wriA-2hnlA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 5 LEU A 102
THR A 180
ILE A  42
VAL A  41
 None
 0.88A 3wriB-2hnlA:
undetectable		 3wriB-2hnlA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 SER A 148
MET A 151
PHE A 142
GLU A 147
 None
 1.11A 4cx7A-2hnlA:
undetectable
4cx7B-2hnlA:
undetectable		 4cx7A-2hnlA:
18.54
4cx7B-2hnlA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 PHE A 142
GLU A 147
SER A 148
MET A 151
 None
 1.29A 4d32A-2hnlA:
undetectable
4d32B-2hnlA:
undetectable		 4d32A-2hnlA:
18.62
4d32B-2hnlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 4 ALA A 177
VAL A 181
ASP A 178
LEU A 161
 None
 0.93A 4e7gA-2hnlA:
undetectable		 4e7gA-2hnlA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 PHE A 142
GLU A 147
SER A 148
MET A 151
 None
 1.24A 4v3yA-2hnlA:
undetectable
4v3yB-2hnlA:
1.2		 4v3yA-2hnlA:
18.62
4v3yB-2hnlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2hnl GLUTATHIONE
S-TRANSFERASE 1
(Onchocerca
volvulus) 		4 / 8 SER A 148
MET A 151
PHE A 142
GLU A 147
 None
 1.33A 5uo7A-2hnlA:
undetectable
5uo7B-2hnlA:
undetectable		 5uo7A-2hnlA:
18.38
5uo7B-2hnlA:
18.38