SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ho4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
4 / 8 ARG A  36
VAL A  12
ILE A  67
LEU A  35
None
0.89A 1igxA-2ho4A:
undetectable
1igxA-2ho4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
4 / 7 TYR A 241
THR A 225
THR A  17
VAL A 200
None
1.12A 1tv8B-2ho4A:
undetectable
1tv8B-2ho4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
5 / 12 ALA A 250
ILE A 254
VAL A  12
PHE A  44
MET A  41
None
1.10A 1uduB-2ho4A:
undetectable
1uduB-2ho4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
5 / 12 ALA A 250
ILE A 254
VAL A  12
PHE A  44
MET A  41
None
1.12A 1xozA-2ho4A:
undetectable
1xozA-2ho4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
5 / 12 ALA A 250
ILE A 254
VAL A  12
PHE A  44
MET A  41
None
1.12A 3b2rA-2ho4A:
undetectable
3b2rA-2ho4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
4 / 5 VAL A 176
VAL A 177
GLN A  85
ARG A 190
None
1.29A 3bjwH-2ho4A:
undetectable
3bjwH-2ho4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
4 / 5 VAL A 176
VAL A 177
GLN A  85
ARG A 190
None
1.33A 3bjwB-2ho4A:
undetectable
3bjwB-2ho4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
4 / 6 ILE A 221
VAL A 200
LEU A   7
HIS A 253
None
0.88A 3kp6A-2ho4A:
undetectable
3kp6B-2ho4A:
undetectable
3kp6A-2ho4A:
20.00
3kp6B-2ho4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
3 / 3 ASN A  47
ASN A  15
GLU A  51
None
MG  A 260 (-4.1A)
PO4  A 404 (-3.7A)
0.85A 3kpdC-2ho4A:
undetectable
3kpdC-2ho4A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
4 / 6 LEU A 189
LEU A 186
ILE A 216
MET A 218
None
0.89A 4ww7A-2ho4A:
undetectable
4ww7A-2ho4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
5 / 12 LEU A  92
PHE A 102
VAL A 105
PRO A  90
GLY A 137
None
1.24A 5f9zB-2ho4A:
2.2
5f9zB-2ho4A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus
musculus)
3 / 3 PHE A  44
ASP A  13
LEU A  76
None
MG  A 260 (-2.4A)
None
0.78A 5uhcC-2ho4A:
undetectable
5uhcC-2ho4A:
15.14