SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ho5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 4 THR A 316
GLN A 315
GLU A 308
ASP A 302
 None
 1.38A 1nw3A-2ho5A:
2.5		 1nw3A-2ho5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 8 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.92A 1v55N-2ho5A:
undetectable
1v55W-2ho5A:
undetectable		 1v55N-2ho5A:
20.46
1v55W-2ho5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 11 GLU A 280
ALA A 120
GLU A 118
ALA A  95
ASP A 302
 None
 1.34A 2admA-2ho5A:
4.8		 2admA-2ho5A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 8 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.93A 2einA-2ho5A:
undetectable
2einJ-2ho5A:
undetectable		 2einA-2ho5A:
20.46
2einJ-2ho5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 8 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.90A 3ag3N-2ho5A:
0.0
3ag3W-2ho5A:
undetectable		 3ag3N-2ho5A:
20.46
3ag3W-2ho5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 6 LEU A 209
GLY A 227
LEU A 203
SER A 206
 None
 0.87A 3aiaA-2ho5A:
2.0		 3aiaA-2ho5A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 183
TYR A 184
GLY A 179
LEU A 175
HIS A 307
 None
 1.12A 3e23A-2ho5A:
4.2		 3e23A-2ho5A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 12 PHE A  63
LEU A  55
PHE A  58
ILE A  68
ALA A  79
 None
 1.14A 3nxuB-2ho5A:
undetectable		 3nxuB-2ho5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 12 ALA A 143
PHE A 145
ILE A 131
LEU A 135
VAL A 140
 None
 0.83A 3w67C-2ho5A:
undetectable		 3w67C-2ho5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		3 / 3 ASP A 302
GLY A 191
TYR A 301
 None
 0.76A 3w9tC-2ho5A:
undetectable		 3w9tC-2ho5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		3 / 3 ASP A 302
GLY A 191
TYR A 301
 None
 0.76A 3w9tG-2ho5A:
undetectable		 3w9tG-2ho5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 6 GLY A 227
TYR A 181
ALA A 148
GLU A 251
 None
 0.99A 4ae1A-2ho5A:
undetectable		 4ae1A-2ho5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 11 GLY A 211
ALA A 148
GLY A 179
ILE A 270
LEU A 268
 None
 1.13A 4kt0A-2ho5A:
undetectable
4kt0J-2ho5A:
undetectable		 4kt0A-2ho5A:
18.81
4kt0J-2ho5A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 247
ALA A 143
ASN A 122
ILE A 253
ALA A 186
 None
 1.16A 4nkvC-2ho5A:
undetectable		 4nkvC-2ho5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 12 GLN A  78
LEU A 105
ASN A  72
SER A  70
ILE A  68
 None
 0.93A 4pb1A-2ho5A:
undetectable		 4pb1A-2ho5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 8 ILE A  90
VAL A  29
LEU A  28
ILE A  49
PHE A  16
 None
 1.45A 4r38D-2ho5A:
undetectable		 4r38D-2ho5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ASP A  64
LYS A  87
HIS A  88
ILE A 288
 None
 0.50A 5a06A-2ho5A:
31.2		 5a06A-2ho5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 5 ASP A  64
LYS A  87
HIS A  88
ILE A 288
 None
 0.55A 5a06B-2ho5A:
31.2		 5a06B-2ho5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 5 ASP A  64
LYS A  87
HIS A  88
ILE A 288
 None
 0.53A 5a06D-2ho5A:
31.1		 5a06D-2ho5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 5 ASP A  64
LYS A  87
HIS A  88
ILE A 288
 None
 0.50A 5a06F-2ho5A:
31.2		 5a06F-2ho5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 8 LEU A 247
ILE A 257
THR A 240
LEU A 135
 None
 0.88A 5eseA-2ho5A:
undetectable		 5eseA-2ho5A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A  55
PHE A  58
LEU A   4
LEU A  65
ALA A  69
 None
 0.96A 5ieoA-2ho5A:
undetectable		 5ieoA-2ho5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A  55
PHE A  58
LEU A   4
LEU A  65
ALA A  69
 None
 1.00A 5iepA-2ho5A:
undetectable		 5iepA-2ho5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 8 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.90A 5xdxN-2ho5A:
undetectable
5xdxW-2ho5A:
undetectable		 5xdxN-2ho5A:
20.46
5xdxW-2ho5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Streptococcus
pneumoniae) 		4 / 8 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.93A 5zcoA-2ho5A:
undetectable
5zcoJ-2ho5A:
undetectable		 5zcoA-2ho5A:
20.46
5zcoJ-2ho5A:
18.18