SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hoe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 236
GLY A 293
GLY A 231
GLY A 213
 None
None
K  A 369 ( 4.7A)
GOL  A 370 (-3.6A)
 0.73A 1d0vA-2hoeA:
undetectable		 1d0vA-2hoeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 0.95A 1ddrA-2hoeA:
undetectable		 1ddrA-2hoeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 0.96A 1ddsA-2hoeA:
undetectable		 1ddsA-2hoeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 0.96A 1dyiA-2hoeA:
undetectable		 1dyiA-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.09A 1dyiB-2hoeA:
undetectable		 1dyiB-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 11 LEU A 168
LEU A 106
LEU A 116
VAL A 142
ILE A  87
 None
 1.12A 1ee2A-2hoeA:
undetectable		 1ee2A-2hoeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 11 LEU A 168
LEU A 106
LEU A 116
VAL A 142
ILE A  87
 None
 1.08A 1ee2B-2hoeA:
undetectable		 1ee2B-2hoeA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 6 TYR A 235
GLY A 234
GLY A 146
TYR A 229
 None
None
GOL  A 370 (-3.4A)
None
 0.97A 1eswA-2hoeA:
undetectable		 1eswA-2hoeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 8 ALA A 214
GLY A 189
ILE A 349
ILE A 308
ILE A 206
 None
 1.28A 1hshD-2hoeA:
undetectable		 1hshD-2hoeA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 236
GLY A 293
GLY A 231
GLY A 213
 None
None
K  A 369 ( 4.7A)
GOL  A 370 (-3.6A)
 0.70A 1jhqA-2hoeA:
undetectable		 1jhqA-2hoeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 THR A 236
GLY A 293
GLY A 231
GLY A 213
 None
None
K  A 369 ( 4.7A)
GOL  A 370 (-3.6A)
 0.71A 1jhvA-2hoeA:
undetectable		 1jhvA-2hoeA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 7 LEU A 163
ILE A 155
ILE A 349
PRO A 145
 None
None
None
GOL  A 370 (-4.4A)
 0.69A 1oniB-2hoeA:
undetectable
1oniC-2hoeA:
undetectable		 1oniB-2hoeA:
16.35
1oniC-2hoeA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 0.98A 1rd7A-2hoeA:
undetectable		 1rd7A-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 0.97A 1rd7B-2hoeA:
undetectable		 1rd7B-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 ALA A 186
ASN A 184
GLY A 211
GLY A 234
 GOL  A 370 ( 4.2A)
GOL  A 370 ( 3.1A)
None
None
 0.87A 1rukH-2hoeA:
undetectable
1rukL-2hoeA:
undetectable		 1rukH-2hoeA:
17.37
1rukL-2hoeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 0.96A 1tdrA-2hoeA:
undetectable		 1tdrA-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 LEU A 171
ASN A 170
LEU A 172
ALA A 169
LEU A 163
 None
 1.18A 2aa6A-2hoeA:
undetectable		 2aa6A-2hoeA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 SER A  23
LEU A  27
ARG A  16
GLU A  30
 None
 1.07A 2j2pA-2hoeA:
undetectable
2j2pB-2hoeA:
undetectable		 2j2pA-2hoeA:
18.16
2j2pB-2hoeA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		3 / 3 ASP A  85
THR A 141
GLU A  81
 None
 0.81A 2zifB-2hoeA:
undetectable		 2zifB-2hoeA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 123
VAL A  82
ILE A 148
VAL A 182
VAL A 180
 None
 1.04A 3iw1A-2hoeA:
undetectable		 3iw1A-2hoeA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 6 ALA A  89
ILE A 122
LEU A  78
GLU A  81
ALA A 353
 None
 1.10A 3r9sA-2hoeA:
undetectable		 3r9sA-2hoeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 6 ILE A 122
LEU A  78
GLU A  81
ALA A 353
 None
 0.87A 3r9sC-2hoeA:
undetectable		 3r9sC-2hoeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 7 ILE A 122
LEU A  78
GLU A  81
ALA A 353
 None
 0.82A 3r9tB-2hoeA:
undetectable		 3r9tB-2hoeA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 11 ILE A 323
MET A 339
ILE A 298
VAL A 327
PHE A 290
 None
 1.25A 3rf4A-2hoeA:
undetectable
3rf4B-2hoeA:
undetectable		 3rf4A-2hoeA:
16.57
3rf4B-2hoeA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 ASN A 184
ASP A 157
GLY A 211
ILE A 212
 GOL  A 370 ( 3.1A)
None
None
None
 0.69A 3so9A-2hoeA:
undetectable		 3so9A-2hoeA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 LEU A 116
VAL A  82
LEU A 171
TYR A 120
 None
 0.97A 3v81A-2hoeA:
3.7		 3v81A-2hoeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 123
LEU A 171
LEU A 168
ILE A  80
VAL A  82
 None
 1.05A 4c9lA-2hoeA:
undetectable		 4c9lA-2hoeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 123
LEU A 171
LEU A 168
ILE A  80
VAL A  82
 None
 1.05A 4c9lB-2hoeA:
undetectable		 4c9lB-2hoeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 123
LEU A 171
LEU A 168
ILE A  80
VAL A  82
 None
 1.07A 4c9oA-2hoeA:
undetectable		 4c9oA-2hoeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.00A 4dfrA-2hoeA:
undetectable		 4dfrA-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ARG A 288
ILE A 206
SER A 291
GLY A 293
LEU A 295
 None
 0.86A 4e1gB-2hoeA:
undetectable		 4e1gB-2hoeA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.01A 4ej1A-2hoeA:
undetectable		 4ej1A-2hoeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 0.97A 4ej1B-2hoeA:
undetectable		 4ej1B-2hoeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.02A 4i13A-2hoeA:
undetectable		 4i13A-2hoeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 VAL A 250
PHE A 312
PHE A 319
PHE A 311
THR A 208
 None
 1.43A 4iaqA-2hoeA:
undetectable		 4iaqA-2hoeA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 GLU A  81
VAL A  82
PRO A 145
GLU A 248
GLU A 232
 None
None
GOL  A 370 (-4.4A)
GOL  A 370 ( 3.9A)
GOL  A 370 (-2.9A)
 1.09A 4k88A-2hoeA:
undetectable		 4k88A-2hoeA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 4 ALA A 350
ALA A 353
ALA A 354
ALA A 357
 None
 0.10A 4oadA-2hoeA:
undetectable		 4oadA-2hoeA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 4 ALA A 350
ALA A 353
ALA A 354
ALA A 357
 None
 0.10A 4oaeA-2hoeA:
undetectable		 4oaeA-2hoeA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		4 / 8 LEU A 116
VAL A  82
LEU A 171
TYR A 120
 None
 0.92A 4puoC-2hoeA:
5.7		 4puoC-2hoeA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.00A 4qleA-2hoeA:
undetectable		 4qleA-2hoeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.02A 4qlgB-2hoeA:
undetectable		 4qlgB-2hoeA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.02A 4x5fA-2hoeA:
undetectable		 4x5fA-2hoeA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.05A 4x5gA-2hoeA:
undetectable		 4x5gA-2hoeA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.03A 4x5hA-2hoeA:
undetectable		 4x5hA-2hoeA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.06A 5e8qB-2hoeA:
undetectable		 5e8qB-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.05A 5eajB-2hoeA:
undetectable		 5eajB-2hoeA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2hoe N-ACETYLGLUCOSAMINE
KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 323
LEU A 297
THR A 208
ILE A 212
LEU A 247
 None
 1.06A 5ujxB-2hoeA:
undetectable		 5ujxB-2hoeA:
16.71