SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hoq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 LEU A 103
LEU A 106
ILE A 128
LEU A 171
VAL A   2
 None
 1.20A 1hrkA-2hoqA:
3.2		 1hrkA-2hoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 10 GLY A 174
ILE A   5
GLY A 114
ILE A 115
ALA A  99
 None
 1.02A 1sh9B-2hoqA:
undetectable		 1sh9B-2hoqA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 LEU A  65
LEU A  36
GLY A  81
ALA A  27
ALA A  23
 None
 1.01A 2bm9C-2hoqA:
3.4		 2bm9C-2hoqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 LEU A  65
LEU A  36
GLY A  81
ALA A  27
ALA A  23
 None
 1.15A 2br4A-2hoqA:
undetectable		 2br4A-2hoqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 LEU A  65
LEU A  36
GLY A  81
ALA A  27
ALA A  23
 None
 1.11A 2br4E-2hoqA:
3.0		 2br4E-2hoqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 LEU A 103
LEU A 106
ILE A 128
LEU A 171
VAL A   2
 None
 1.21A 2hrcB-2hoqA:
2.3		 2hrcB-2hoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 LEU A 103
LEU A 106
ILE A 128
LEU A 171
VAL A   2
 None
 1.16A 2po7A-2hoqA:
3.2		 2po7A-2hoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 LEU A 103
LEU A 106
ILE A 128
LEU A 171
VAL A   2
 None
 1.18A 2po7B-2hoqA:
3.5		 2po7B-2hoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		3 / 3 LEU A 131
VAL A 102
ARG A 100
 None
 0.85A 3b0wB-2hoqA:
undetectable		 3b0wB-2hoqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 11 ALA A 162
VAL A   4
GLY A 114
ILE A 115
ILE A 155
 None
 0.97A 3ebzB-2hoqA:
undetectable		 3ebzB-2hoqA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		3 / 3 LEU A  71
PRO A  72
LEU A  66
 None
 0.50A 3hcrA-2hoqA:
3.3		 3hcrA-2hoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 11 VAL A 192
ALA A 210
SER A 219
LEU A 217
VAL A 173
 None
 1.43A 4eilA-2hoqA:
2.5		 4eilA-2hoqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 11 VAL A 192
ALA A 210
SER A 219
LEU A 217
VAL A 173
 None
 1.44A 4eilC-2hoqA:
2.5		 4eilC-2hoqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 ILE A 214
LEU A  13
ILE A   5
LEU A 224
VAL A 192
 None
 1.03A 4kfjB-2hoqA:
2.4		 4kfjB-2hoqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 12 VAL A 192
ALA A 210
SER A 219
LEU A 217
VAL A 173
 None
 1.46A 4kyaF-2hoqA:
undetectable		 4kyaF-2hoqA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 11 LEU A 133
VAL A  96
LEU A 217
LEU A 131
LEU A 103
 None
 1.13A 4or0B-2hoqA:
2.0		 4or0B-2hoqA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQL_A_KANA203_1
(2''-AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 9 ASP A 175
ASP A   8
ASP A 180
ILE A 155
ASP A 118
 None
 1.23A 4wqlA-2hoqA:
0.0		 4wqlA-2hoqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		5 / 8 ASP A 175
ASP A   8
ASP A 180
ILE A 155
ASP A 118
 None
 1.17A 4xjeA-2hoqA:
undetectable		 4xjeA-2hoqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		4 / 8 THR A  12
PHE A 137
PHE A 194
ILE A   5
 None
 1.10A 5vkqB-2hoqA:
2.3
5vkqC-2hoqA:
2.3		 5vkqB-2hoqA:
8.30
5vkqC-2hoqA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2hoq PUTATIVE
HAD-HYDROLASE PH1655
(Pyrococcus
horikoshii) 		4 / 5 LEU A 106
VAL A 102
GLU A 218
LEU A 221
 None
 1.08A 5xooB-2hoqA:
undetectable		 5xooB-2hoqA:
17.83