SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hpa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 8 SER A1193
ALA A1195
TRP A1194
PHE A1021
 None
 1.09A 1dmiA-2hpaA:
undetectable
1dmiB-2hpaA:
undetectable		 1dmiA-2hpaA:
20.88
1dmiB-2hpaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		3 / 3 SER A1142
GLU A1143
GLU A1144
 None
 0.59A 1eqbD-2hpaA:
undetectable		 1eqbD-2hpaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		3 / 3 SER A1142
GLU A1143
GLU A1144
 None
 0.59A 1eqbB-2hpaA:
undetectable		 1eqbB-2hpaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 8 ASP A1179
GLY A1042
THR A1039
GLY A1036
 None
 0.80A 1jr1B-2hpaA:
undetectable		 1jr1B-2hpaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		3 / 3 ASP A1119
LEU A1116
HIS A1046
 None
 0.71A 1qknA-2hpaA:
undetectable		 1qknA-2hpaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 5 GLU A1095
PRO A1094
ILE A1099
GLY A1096
 None
 1.17A 2qeuA-2hpaA:
undetectable
2qeuC-2hpaA:
undetectable		 2qeuA-2hpaA:
17.15
2qeuC-2hpaA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		5 / 12 THR A1284
LEU A1321
PHE A1324
ALA A1325
GLY A1229
 None
 1.02A 2ve3A-2hpaA:
0.4		 2ve3A-2hpaA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 6 ILE A1332
VAL A1328
LEU A1268
LEU A1264
 None
 0.87A 3kp6A-2hpaA:
0.5
3kp6B-2hpaA:
undetectable		 3kp6A-2hpaA:
15.27
3kp6B-2hpaA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		5 / 12 LEU A1203
PHE A1155
ILE A1156
SER A1163
LEU A1165
 None
 1.22A 3n8xA-2hpaA:
undetectable		 3n8xA-2hpaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 7 ARG A1300
LEU A1283
GLU A1285
ILE A1053
 None
 0.89A 3s56B-2hpaA:
undetectable		 3s56B-2hpaA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 7 PHE A1010
ALA A1084
ILE A1109
LEU A1091
 None
 0.92A 4uymA-2hpaA:
undetectable		 4uymA-2hpaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 7 PHE A1010
ALA A1084
ILE A1109
LEU A1091
 None
 0.89A 4uymB-2hpaA:
0.6		 4uymB-2hpaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		5 / 11 LEU A1283
GLY A1050
LEU A1091
PHE A1010
PHE A1092
 None
 1.36A 4wnuC-2hpaA:
undetectable		 4wnuC-2hpaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 6 PRO A1307
LEU A1049
GLU A1048
TYR A1052
 None
 1.11A 4z4cA-2hpaA:
undetectable		 4z4cA-2hpaA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		4 / 5 LEU A1159
PHE A1021
LEU A1165
TRP A1194
 None
 1.44A 5m10A-2hpaA:
undetectable		 5m10A-2hpaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		5 / 12 VAL A1009
LEU A1122
GLY A1228
SER A1224
PHE A1132
 None
 1.06A 5vooA-2hpaA:
undetectable		 5vooA-2hpaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		5 / 12 VAL A1009
LEU A1122
GLY A1228
SER A1224
PHE A1132
 None
 1.09A 5vooC-2hpaA:
undetectable		 5vooC-2hpaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2hpa PROTEIN (ACID
PHOSPHATASE)
(Homo
sapiens) 		3 / 3 LEU A1312
ASN A1233
LEU A1264
 None
 0.65A 6exiA-2hpaA:
undetectable		 6exiA-2hpaA:
15.14