SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 VAL A  57
LEU A 256
SER A 249
VAL A 248
GLU A 265
 None
 1.22A 1fdwA-2hpgA:
undetectable		 1fdwA-2hpgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		6 / 12 LEU A 123
GLY A 272
ILE A 279
PRO A 116
ALA A 119
ILE A 120
 None
 1.01A 1rl8B-2hpgA:
undetectable		 1rl8B-2hpgA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 LEU A 123
PRO A 116
ALA A 119
ILE A 120
 None
 0.96A 2aofB-2hpgA:
undetectable		 2aofB-2hpgA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 123
GLY A 272
ILE A 279
ALA A 119
ILE A 120
 None
 0.86A 2nmzA-2hpgA:
undetectable		 2nmzA-2hpgA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		6 / 12 LEU A 123
GLY A 272
ILE A 279
PRO A 116
ALA A 119
ILE A 120
 None
 0.94A 2nmzB-2hpgA:
undetectable		 2nmzB-2hpgA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 123
GLY A 272
ILE A 279
ALA A 119
ILE A 120
 None
 0.72A 2rkfA-2hpgA:
undetectable		 2rkfA-2hpgA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 123
GLY A 272
ILE A 279
ALA A 119
ILE A 120
 None
 0.78A 2rkfB-2hpgA:
undetectable		 2rkfB-2hpgA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 PRO A 195
THR A 178
PRO A 179
GLY A 180
 None
 1.03A 2vl2B-2hpgA:
undetectable		 2vl2B-2hpgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 GLN A 261
SER A 255
TYR A 260
TYR A  24
 None
 1.43A 2xz5D-2hpgA:
undetectable
2xz5E-2hpgA:
undetectable		 2xz5D-2hpgA:
19.09
2xz5E-2hpgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 243
PHE A 245
MET A 132
THR A 131
 None
 0.92A 3ag2N-2hpgA:
undetectable
3ag2W-2hpgA:
undetectable		 3ag2N-2hpgA:
19.92
3ag2W-2hpgA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 TYR A 260
ILE A 263
ILE A 264
ILE A  59
 None
 0.67A 3p4wC-2hpgA:
undetectable		 3p4wC-2hpgA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLU A 246
PHE A  42
ILE A  74
GLN A 154
ILE A 247
 None
 1.24A 4djfA-2hpgA:
undetectable		 4djfA-2hpgA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 PHE A 150
PHE A 245
THR A 131
LEU A 329
 None
 0.99A 4ejgD-2hpgA:
undetectable		 4ejgD-2hpgA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A  92
LEU A 136
ILE A 243
PHE A 150
 None
 1.21A 4y4dA-2hpgA:
undetectable		 4y4dA-2hpgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 GLU A 265
GLU A 246
THR A  87
LEU A 139
 None
 1.11A 5hm8G-2hpgA:
undetectable		 5hm8G-2hpgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A  52
LEU A 256
ILE A  59
 None
 0.71A 5kc0A-2hpgA:
0.9		 5kc0A-2hpgA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 LEU A 139
ALA A 183
SER A 187
THR A  87
LEU A 242
 None
 1.42A 5mm4B-2hpgA:
undetectable		 5mm4B-2hpgA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 260
ILE A 263
ILE A 264
ILE A  59
 None
 0.73A 5murB-2hpgA:
undetectable		 5murB-2hpgA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2hpg ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 214
ALA A 206
ASP A 213
PHE A 159
THR A 161
 None
 1.29A 5x6yC-2hpgA:
0.1		 5x6yC-2hpgA:
16.48