SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hpi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ILE A 464
ALA A 433
PRO A 456
ASN A 455
THR A 439
 None
 0.99A 1dhfA-2hpiA:
undetectable		 1dhfA-2hpiA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 ARG A 783
ALA A 755
ALA A 762
GLU A 761
 None
 1.16A 1e7bA-2hpiA:
undetectable		 1e7bA-2hpiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 ARG A 783
ALA A 755
ALA A 762
GLU A 761
 None
 1.17A 1e7bB-2hpiA:
undetectable		 1e7bB-2hpiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 8 ALA A 428
LEU A 448
LEU A 444
ARG A 386
 None
 0.94A 1ereE-2hpiA:
undetectable		 1ereE-2hpiA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 8 ALA A 428
LEU A 448
LEU A 444
ARG A 386
 None
 0.95A 1ereF-2hpiA:
undetectable		 1ereF-2hpiA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 7 LEU A 625
SER A 469
ASP A 470
PHE A 668
 None
 1.17A 1ismB-2hpiA:
2.3		 1ismB-2hpiA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 THR A  14
HIS A  13
HIS A  11
GLU A  72
TYR A  74
 None
ZN  A1222 (-3.3A)
ZN  A1222 (-3.2A)
ZN  A1222 (-2.4A)
None
 1.42A 1j36A-2hpiA:
undetectable		 1j36A-2hpiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 THR A  14
HIS A  13
HIS A  11
GLU A  72
TYR A  74
 None
ZN  A1222 (-3.3A)
ZN  A1222 (-3.2A)
ZN  A1222 (-2.4A)
None
 1.42A 1j36B-2hpiA:
undetectable		 1j36B-2hpiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ALA A 788
GLY A 756
GLU A 782
GLU A 795
ALA A 798
 None
 1.03A 1mjqC-2hpiA:
undetectable
1mjqD-2hpiA:
undetectable		 1mjqC-2hpiA:
7.27
1mjqD-2hpiA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 GLU A 782
GLU A 795
ALA A 798
ALA A 788
GLY A 756
 None
 1.00A 1mjqG-2hpiA:
undetectable
1mjqH-2hpiA:
undetectable		 1mjqG-2hpiA:
7.27
1mjqH-2hpiA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ALA A 788
GLY A 756
GLU A 782
GLU A 795
ALA A 798
 None
 1.04A 1mjqI-2hpiA:
undetectable
1mjqJ-2hpiA:
undetectable		 1mjqI-2hpiA:
7.27
1mjqJ-2hpiA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 8 ILE A 127
GLY A 120
ILE A 131
GLU A 130
 None
 0.84A 1mrjA-2hpiA:
undetectable		 1mrjA-2hpiA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 GLU A  72
HIS A  95
HIS A  47
 ZN  A1222 (-2.4A)
None
ZN  A1221 (-3.1A)
 0.70A 1oe2A-2hpiA:
undetectable		 1oe2A-2hpiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 HIS A  47
GLU A  72
HIS A  13
HIS A 214
 ZN  A1221 (-3.1A)
ZN  A1222 (-2.4A)
ZN  A1222 (-3.3A)
ZN  A1221 (-3.3A)
 1.09A 1os2D-2hpiA:
undetectable		 1os2D-2hpiA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 7 MET A 257
PHE A 271
ASN A 193
GLU A 265
 None
 1.38A 1t9wA-2hpiA:
2.1		 1t9wA-2hpiA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 HIS A  47
GLU A  72
HIS A  13
HIS A 214
 ZN  A1221 (-3.1A)
ZN  A1222 (-2.4A)
ZN  A1222 (-3.3A)
ZN  A1221 (-3.3A)
 1.06A 1utzA-2hpiA:
undetectable		 1utzA-2hpiA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 HIS A  47
GLU A  72
HIS A  13
HIS A 214
 ZN  A1221 (-3.1A)
ZN  A1222 (-2.4A)
ZN  A1222 (-3.3A)
ZN  A1221 (-3.3A)
 1.06A 1utzB-2hpiA:
undetectable		 1utzB-2hpiA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU A  25
ALA A 608
LEU A 285
MET A  44
LEU A  50
 None
 1.38A 1ya3B-2hpiA:
undetectable		 1ya3B-2hpiA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 ARG A1164
VAL A1015
GLY A1075
 None
 0.65A 2avvE-2hpiA:
undetectable		 2avvE-2hpiA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 11 LEU A 925
VAL A 897
GLY A 898
ALA A 934
LEU A 938
 None
 1.04A 2bxgA-2hpiA:
2.4		 2bxgA-2hpiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 GLY A 317
LEU A 318
LEU A 319
ILE A 326
LEU A 354
 None
 0.80A 2f8dA-2hpiA:
undetectable		 2f8dA-2hpiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 LEU A 316
GLY A 317
LEU A 318
LEU A 319
LEU A 354
 None
 1.05A 2f8dA-2hpiA:
undetectable		 2f8dA-2hpiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 GLY A 317
LEU A 318
LEU A 319
ILE A 326
LEU A 354
 None
 0.84A 2f8dB-2hpiA:
undetectable		 2f8dB-2hpiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 LEU A 316
GLY A 317
LEU A 318
LEU A 319
LEU A 354
 None
 1.09A 2f8dB-2hpiA:
undetectable		 2f8dB-2hpiA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ILE A 492
VAL A 580
ALA A 611
VAL A 590
TYR A 106
 None
 1.26A 2g72B-2hpiA:
undetectable		 2g72B-2hpiA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU A  25
ALA A 608
LEU A 285
MET A  44
LEU A  50
 None
 1.21A 2oaxD-2hpiA:
undetectable		 2oaxD-2hpiA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU A  25
ALA A 608
LEU A 285
MET A  44
LEU A  50
 None
 1.38A 2oaxE-2hpiA:
undetectable		 2oaxE-2hpiA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 HIS A  47
GLU A  72
HIS A  13
HIS A 214
 ZN  A1221 (-3.1A)
ZN  A1222 (-2.4A)
ZN  A1222 (-3.3A)
ZN  A1221 (-3.3A)
 1.03A 2ow9B-2hpiA:
undetectable		 2ow9B-2hpiA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 HIS A  47
GLU A  72
HIS A  13
HIS A 214
 ZN  A1221 (-3.1A)
ZN  A1222 (-2.4A)
ZN  A1222 (-3.3A)
ZN  A1221 (-3.3A)
 1.07A 2ozrC-2hpiA:
undetectable		 2ozrC-2hpiA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 4 HIS A  47
GLU A  72
HIS A  13
HIS A 214
 ZN  A1221 (-3.1A)
ZN  A1222 (-2.4A)
ZN  A1222 (-3.3A)
ZN  A1221 (-3.3A)
 1.07A 2ozrD-2hpiA:
undetectable		 2ozrD-2hpiA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ALA A 941
GLY A 890
PRO A 870
LYS A 881
LEU A 906
 None
 1.09A 2plwA-2hpiA:
undetectable		 2plwA-2hpiA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PRO A 125
GLY A  48
TYR A  74
 None
 0.59A 2vouA-2hpiA:
undetectable		 2vouA-2hpiA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PRO A 125
GLY A  48
TYR A  74
 None
 0.64A 2vouB-2hpiA:
undetectable		 2vouB-2hpiA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PRO A 125
GLY A  48
TYR A  74
 None
 0.64A 2vouC-2hpiA:
undetectable		 2vouC-2hpiA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 7 TYR A 331
ALA A 353
ALA A 355
LEU A 391
 None
 0.96A 2wx2A-2hpiA:
undetectable		 2wx2A-2hpiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 TYR A 604
LEU A  50
VAL A 110
VAL A 283
 None
 1.16A 2zawA-2hpiA:
undetectable		 2zawA-2hpiA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PHE A 915
ASN A 874
PHE A 947
 None
 1.06A 2zbuD-2hpiA:
undetectable		 2zbuD-2hpiA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 8 TYR A 604
LEU A  50
VAL A 110
VAL A 283
LEU A 285
 None
 1.43A 2zujA-2hpiA:
undetectable		 2zujA-2hpiA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 ILE A 394
ILE A 410
TYR A 409
PHE A 399
 None
 1.16A 3adsA-2hpiA:
undetectable		 3adsA-2hpiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU A  99
ALA A 141
LEU A 132
LEU A  50
ALA A 100
 None
 1.02A 3dfrA-2hpiA:
undetectable		 3dfrA-2hpiA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 THR A  14
LEU A  25
VAL A  65
GLY A  64
ILE A  69
 None
 1.09A 3ijdA-2hpiA:
3.8		 3ijdA-2hpiA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 LEU A 142
PHE A 178
ILE A 277
CYH A 281
 None
 0.94A 3ko0B-2hpiA:
undetectable		 3ko0B-2hpiA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 8 GLY A 174
ILE A 277
MET A 280
CYH A 281
 None
 0.58A 3ko0K-2hpiA:
0.5
3ko0S-2hpiA:
undetectable		 3ko0K-2hpiA:
6.27
3ko0S-2hpiA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 ALA A 136
ARG A 176
LYS A 101
 None
 0.90A 3kp5B-2hpiA:
undetectable		 3kp5B-2hpiA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 5 GLN A 603
ILE A  69
LEU A  50
PHE A  51
 None
 1.26A 3ls4L-2hpiA:
undetectable		 3ls4L-2hpiA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ILE A 127
VAL A  75
ALA A  73
ARG A 176
ILE A 179
 None
 1.04A 3mb5A-2hpiA:
undetectable		 3mb5A-2hpiA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 7 GLU A 149
LEU A 132
ASP A 169
ARG A 129
 MG  A1224 (-3.0A)
None
MG  A1224 (-2.4A)
None
 1.24A 3mbgA-2hpiA:
undetectable
3mbgB-2hpiA:
undetectable		 3mbgA-2hpiA:
8.12
3mbgB-2hpiA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 VAL A 667
SER A 825
LEU A 670
 None
 0.59A 3n8xA-2hpiA:
0.2		 3n8xA-2hpiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 VAL A 679
VAL A 667
SER A 825
 None
 0.74A 3n8xB-2hpiA:
undetectable		 3n8xB-2hpiA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 GLN A 182
HIS A  13
HIS A  47
HIS A 214
 None
ZN  A1222 (-3.3A)
ZN  A1221 (-3.1A)
ZN  A1221 (-3.3A)
 0.76A 3nvcA-2hpiA:
undetectable		 3nvcA-2hpiA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 SER A 430
ILE A 394
ASP A 408
THR A 466
 None
 1.05A 3q70A-2hpiA:
undetectable		 3q70A-2hpiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 11 LEU A  99
ALA A  73
ILE A 127
THR A 210
GLU A 180
 None
 1.44A 3qelA-2hpiA:
undetectable
3qelB-2hpiA:
undetectable		 3qelA-2hpiA:
15.28
3qelB-2hpiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 GLY A 607
GLU A 610
GLY A 493
VAL A 580
PHE A 495
 None
 1.08A 3qowA-2hpiA:
undetectable		 3qowA-2hpiA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		6 / 12 GLY A 890
GLY A 877
ARG A 909
LEU A 925
VAL A 897
ALA A 934
 None
 1.37A 3t7vA-2hpiA:
2.9		 3t7vA-2hpiA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 11 GLU A 610
LEU A 454
VAL A 459
PHE A 403
PHE A 399
 None
 1.31A 3tbgA-2hpiA:
undetectable		 3tbgA-2hpiA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 PHE A 495
SER A 114
LEU A 586
VAL A 580
VAL A 590
 None
 1.40A 3u9fE-2hpiA:
undetectable		 3u9fE-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PHE A 249
CYH A 246
HIS A 184
 None
 1.18A 3u9fF-2hpiA:
undetectable		 3u9fF-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PHE A 249
CYH A 246
HIS A 184
 None
 1.17A 3u9fG-2hpiA:
undetectable		 3u9fG-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PHE A 249
CYH A 246
HIS A 184
 None
 1.09A 3u9fL-2hpiA:
undetectable		 3u9fL-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 PHE A 495
SER A 114
LEU A 586
VAL A 580
VAL A 590
 None
 1.42A 3u9fR-2hpiA:
undetectable		 3u9fR-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PHE A 249
CYH A 246
HIS A 184
 None
 1.27A 3u9fS-2hpiA:
undetectable		 3u9fS-2hpiA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 5 GLU A  55
GLY A  52
TYR A 604
GLN A 603
 None
 1.37A 3w9tE-2hpiA:
undetectable		 3w9tE-2hpiA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 5 GLU A  55
GLY A  52
TYR A 604
GLN A 603
 None
 1.33A 3w9tG-2hpiA:
undetectable		 3w9tG-2hpiA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 5 LEU A  42
HIS A   9
HIS A  13
HIS A  11
 None
None
ZN  A1222 (-3.3A)
ZN  A1222 (-3.2A)
 1.36A 4a7bB-2hpiA:
undetectable		 4a7bB-2hpiA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 PHE A 177
ALA A 141
GLY A 144
LEU A  96
 None
None
None
MG  A1224 ( 4.7A)
 0.93A 4dubB-2hpiA:
undetectable		 4dubB-2hpiA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 PHE A 298
TYR A 409
TYR A 484
 None
 0.95A 4ffwA-2hpiA:
undetectable		 4ffwA-2hpiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 LYS A 832
LEU A 658
ALA A 829
 None
 0.74A 4iizA-2hpiA:
undetectable		 4iizA-2hpiA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 8 GLU A 306
ASP A 408
ILE A 405
ILE A 581
 None
 0.79A 4kttD-2hpiA:
undetectable		 4kttD-2hpiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 8 TYR A 604
LEU A  50
VAL A 110
VAL A 283
 None
 1.15A 4l4dA-2hpiA:
undetectable		 4l4dA-2hpiA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 7 TYR A 857
ILE A 887
ILE A 866
ALA A 861
 None
 0.87A 4lv9A-2hpiA:
undetectable		 4lv9A-2hpiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 ASP A 803
GLU A 797
VAL A 754
ALA A 755
 None
 0.69A 4nkxA-2hpiA:
undetectable		 4nkxA-2hpiA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 LEU A 318
HIS A 385
LEU A 384
ALA A 387
LEU A 431
 None
 1.24A 4p65A-2hpiA:
undetectable
4p65B-2hpiA:
undetectable
4p65F-2hpiA:
undetectable
4p65H-2hpiA:
undetectable		 4p65A-2hpiA:
1.55
4p65B-2hpiA:
2.42
4p65F-2hpiA:
2.42
4p65H-2hpiA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 11 LEU A 318
HIS A 385
LEU A 384
ALA A 387
LEU A 431
 None
 1.03A 4p65E-2hpiA:
undetectable
4p65F-2hpiA:
undetectable
4p65J-2hpiA:
undetectable
4p65L-2hpiA:
undetectable		 4p65E-2hpiA:
1.55
4p65F-2hpiA:
2.42
4p65J-2hpiA:
2.42
4p65L-2hpiA:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 11 PHE A 813
GLY A 447
LEU A 448
GLU A 745
ALA A 692
 None
 1.30A 4wnuC-2hpiA:
undetectable		 4wnuC-2hpiA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 11 LEU A1021
TYR A1018
HIS A1013
GLU A1073
LEU A1070
 None
 1.19A 4yvpA-2hpiA:
4.0		 4yvpA-2hpiA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 7 TYR A 645
TYR A 835
GLU A 838
PHE A 627
 None
 1.09A 5aclA-2hpiA:
undetectable		 5aclA-2hpiA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU A  99
ALA A  73
ILE A 127
THR A 210
GLU A 180
 None
 1.42A 5ewjC-2hpiA:
undetectable
5ewjD-2hpiA:
undetectable		 5ewjC-2hpiA:
15.41
5ewjD-2hpiA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 PHE A 103
GLY A 105
GLN A 107
TYR A 604
LEU A  50
 None
 1.32A 5ji0D-2hpiA:
0.0		 5ji0D-2hpiA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 ARG A 909
GLY A 913
PRO A 914
GLU A 910
 None
 1.09A 5ny7A-2hpiA:
undetectable		 5ny7A-2hpiA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 HIS A 214
ASP A  20
HIS A  47
 ZN  A1221 (-3.3A)
ZN  A1221 (-2.4A)
ZN  A1221 (-3.1A)
 0.68A 5oexA-2hpiA:
undetectable		 5oexA-2hpiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 HIS A 214
ASP A  20
HIS A  47
 ZN  A1221 (-3.3A)
ZN  A1221 (-2.4A)
ZN  A1221 (-3.1A)
 0.69A 5oexB-2hpiA:
undetectable		 5oexB-2hpiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 HIS A 214
ASP A  20
HIS A  47
 ZN  A1221 (-3.3A)
ZN  A1221 (-2.4A)
ZN  A1221 (-3.1A)
 0.67A 5oexC-2hpiA:
undetectable		 5oexC-2hpiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 HIS A 214
ASP A  20
HIS A  47
 ZN  A1221 (-3.3A)
ZN  A1221 (-2.4A)
ZN  A1221 (-3.1A)
 0.67A 5oexD-2hpiA:
undetectable		 5oexD-2hpiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 8 GLU A 306
ASP A 408
ILE A 405
ILE A 581
 None
 0.85A 5t8sA-2hpiA:
undetectable		 5t8sA-2hpiA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 10 ILE A1008
GLY A1007
LEU A 844
SER A 845
VAL A 854
 None
 1.03A 5twjB-2hpiA:
undetectable		 5twjB-2hpiA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ILE A1008
GLY A1007
LEU A 844
SER A 845
VAL A 854
 None
 1.03A 5twjC-2hpiA:
undetectable		 5twjC-2hpiA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 GLY A 760
ASN A 455
ARG A 766
 None
 0.67A 5w7bD-2hpiA:
undetectable		 5w7bD-2hpiA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 5 LEU A 205
LYS A 202
LEU A 166
GLU A 163
 None
 1.34A 5weaA-2hpiA:
2.9		 5weaA-2hpiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 PHE A 103
GLY A 105
GLN A 107
TYR A 604
LEU A  50
 None
 1.17A 5y2tA-2hpiA:
undetectable		 5y2tA-2hpiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		3 / 3 TYR A 757
HIS A 780
MET A 769
 None
 1.16A 6af6A-2hpiA:
undetectable		 6af6A-2hpiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU A 592
ASP A 487
THR A 602
GLY A 613
LEU A 612
 None
 1.19A 6b0lB-2hpiA:
undetectable		 6b0lB-2hpiA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		4 / 6 LEU A  18
VAL A  32
PHE A  51
GLY A  48
 None
 1.03A 6hd4B-2hpiA:
undetectable		 6hd4B-2hpiA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 2hpi DNA POLYMERASE III
ALPHA SUBUNIT
(Thermus
aquaticus) 		5 / 12 ALA A 387
TYR A 389
PHE A 450
VAL A 432
VAL A 436
 None
 1.50A 6hu9N-2hpiA:
undetectable		 6hu9N-2hpiA:
13.87