SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2hpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 2hpq PROTHROMBIN
(Homo
sapiens) 		4 / 8 ASP P 354
ASP P 356
TRP P 361
TYR P 363
 None
 0.78A 1ceaA-2hpqP:
undetectable
1ceaB-2hpqP:
undetectable		 1ceaA-2hpqP:
35.71
1ceaB-2hpqP:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2hpq PROTHROMBIN
(Homo
sapiens) 		4 / 7 ASP P 354
ASP P 356
TRP P 361
TYR P 363
 None
 0.76A 1ceaB-2hpqP:
undetectable		 1ceaB-2hpqP:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2hpq PROTHROMBIN
(Homo
sapiens) 		4 / 7 ASP P 354
ASP P 356
TRP P 361
TYR P 363
 None
 0.80A 1cebA-2hpqP:
10.5		 1cebA-2hpqP:
35.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2hpq PROTHROMBIN
(Homo
sapiens) 		4 / 5 LEU P 313
VAL P 360
TYR P 309
ARG P 351
 None
 1.41A 1nw3A-2hpqP:
undetectable		 1nw3A-2hpqP:
9.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BVV_A_CPFA1081_1
(APOLIPOPROTEIN(A))		 2hpq PROTHROMBIN
(Homo
sapiens) 		5 / 9 ASP P 354
ASP P 356
TRP P 361
TYR P 363
PHE P 371
 None
 0.82A 4bvvA-2hpqP:
10.6		 4bvvA-2hpqP:
40.96